CHEBI:9362 - suprofen

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ChEBI Name suprofen
ChEBI ID CHEBI:9362
Definition An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:193117
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Formula C14H12O3S
Net Charge 0
Average Mass 260.30800
Monoisotopic Mass 260.05072
InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
InChIKey MDKGKXOCJGEUJW-UHFFFAOYSA-N
SMILES CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
drug allergen
Any drug which causes the onset of an allergic reaction.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
peripheral nervous system drug
A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
drug allergen
Any drug which causes the onset of an allergic reaction.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing suprofen (CHEBI:9362) has role antirheumatic drug (CHEBI:35842)
suprofen (CHEBI:9362) has role drug allergen (CHEBI:88188)
suprofen (CHEBI:9362) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
suprofen (CHEBI:9362) has role non-narcotic analgesic (CHEBI:35481)
suprofen (CHEBI:9362) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
suprofen (CHEBI:9362) has role peripheral nervous system drug (CHEBI:49110)
suprofen (CHEBI:9362) is a aromatic ketone (CHEBI:76224)
suprofen (CHEBI:9362) is a monocarboxylic acid (CHEBI:25384)
suprofen (CHEBI:9362) is a thiophenes (CHEBI:26961)
IUPAC Name
2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid
INNs Sources
suprofen ChemIDplus
suprofene ChemIDplus
suprofenum ChemIDplus
Synonyms Sources
(±)-2-(p-(2-thenoyl)phenyl)propionic acid ChemIDplus
2-(4-(2-Thenoyl)phenyl)propionsäure ChemIDplus
2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid ChEMBL
4-(2-Thenoyl)hydratropsäure ChemIDplus
α-methyl-4-(2-thienylcarbonyl)benzeneacetic acid ChemIDplus
p-2-thenoylhydratropic acid ChemIDplus
PROFENAL ChEMBL
SUTOPROFEN ChEMBL
Manual Xrefs Databases
2546 DrugCentral
C07320 KEGG COMPOUND
D00452 KEGG DRUG
DB00870 DrugBank
DE2353357 Patent
LSM-4406 LINCS
Suprofen Wikipedia
US4035376 Patent
View more database links
Registry Numbers Types Sources
1430606 Reaxys Registry Number Reaxys
1430606 Beilstein Registry Number Beilstein
40828-46-4 CAS Registry Number KEGG COMPOUND
Citations Waiting for Citations Types Sources
11195850 PubMed citation Europe PMC
11409928 PubMed citation Europe PMC
14570769 PubMed citation Europe PMC
14664336 PubMed citation Europe PMC
27559371 PubMed citation Europe PMC
7918773 PubMed citation Europe PMC
8058269 PubMed citation Europe PMC
Last Modified
12 March 2019