ML-236C (CHEBI:34828)

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ChEBI Name	ML-236C

ChEBI ID	CHEBI:34828

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C18H26O3

Net Charge

Average Mass

290.403

Monoisotopic Mass

290.18819

InChI

InChI=1S/C18H26O3/c1-12-6-7-13-4-2-3-5-17(13)16(12)9-8-15-10-14(19)11-18(20)21-15/h4,6-7,12,14-17,19H,2-3,5,8-11H2,1H3/t12-,14+,15+,16-,17-/m0/s1

InChIKey

NXIASLUNMKAUTN-WFKFIOEPSA-N

SMILES

C1CC=C2[C@](C1)([C@H]([C@H](C=C2)C)CC[C@H]3OC(C[C@@H](C3)O)=O)[H]

Metabolite of Species	Details
Penicillium citrinum (NCBI:txid5077)	Found in cell suspension culture (BTO:0000221). of strain SANK 18767 See: PubMed

Roles Classification
Biological Role(s):	fungal metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.

Application(s):	anticholesteremic drug A substance used to lower plasma cholesterol levels. antilipemic drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.

ChEBI Ontology
Outgoing	ML-236C (CHEBI:34828) has role antiatherosclerotic agent (CHEBI:145947) ML-236C (CHEBI:34828) has role anticholesteremic drug (CHEBI:35821) ML-236C (CHEBI:34828) has role antilipemic drug (CHEBI:35679) ML-236C (CHEBI:34828) has role antimicrobial agent (CHEBI:33281) ML-236C (CHEBI:34828) has role EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor (CHEBI:35664) ML-236C (CHEBI:34828) has role fungal metabolite (CHEBI:76946) ML-236C (CHEBI:34828) is a 2-pyranones (CHEBI:75885) ML-236C (CHEBI:34828) is a carbobicyclic compound (CHEBI:36785) ML-236C (CHEBI:34828) is a hexahydronaphthalenes (CHEBI:142348) ML-236C (CHEBI:34828) is a polyketide (CHEBI:26188) ML-236C (CHEBI:34828) is a secondary alcohol (CHEBI:35681)

Incoming	compactin diol lactone (CHEBI:34652) has functional parent ML-236C (CHEBI:34828)

IUPAC Name

(4R,6R)-4-hydroxy-6-{2-[(1S,2S,8aR)-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}tetrahydro-2H-pyran-2-one

Synonyms	Sources
(4R,6R)-4-hydroxy-6-{2-[(1S,2S,8aR)-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}oxan-2-one	IUPAC
Antibiotic ML 236C	ChEBI
ML 236C	KNApSAcK
ML-236C	KEGG COMPOUND

Last Modified

30 January 2020