brivanib (CHEBI:167686)

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ChEBI Name	brivanib

ChEBI ID	CHEBI:167686

Definition	A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C19H19FN4O3

Net Charge

Average Mass

370.384

Monoisotopic Mass

370.14412

InChI

InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1

InChIKey

WCWUXEGQKLTGDX-LLVKDONJSA-N

SMILES

C[C@@H](O)COC1=CN2N=CN=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)C2=C1C

Roles Classification
Biological Role(s):	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. fibroblast growth factor receptor antagonist An antagonist at the fibroblast growth factor receptor. drug metabolite

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	brivanib (CHEBI:167686) has role angiogenesis inhibitor (CHEBI:48422) brivanib (CHEBI:167686) has role antineoplastic agent (CHEBI:35610) brivanib (CHEBI:167686) has role apoptosis inducer (CHEBI:68495) brivanib (CHEBI:167686) has role drug metabolite (CHEBI:49103) brivanib (CHEBI:167686) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) brivanib (CHEBI:167686) has role fibroblast growth factor receptor antagonist (CHEBI:63457) brivanib (CHEBI:167686) is a aromatic ether (CHEBI:35618) brivanib (CHEBI:167686) is a diether (CHEBI:46786) brivanib (CHEBI:167686) is a fluoroindole (CHEBI:131960) brivanib (CHEBI:167686) is a pyrrolotriazine (CHEBI:88341) brivanib (CHEBI:167686) is a secondary alcohol (CHEBI:35681)

Incoming	brivanib alaninate (CHEBI:167656) has functional parent brivanib (CHEBI:167686)

IUPAC Name

(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol

Synonyms	Sources
(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol	ChEBI
BMS 540215	ChemIDplus
BMS-540215	ChemIDplus
BMS540215	ChemIDplus

Registry Number	Type	Source
649735-46-6	CAS Registry Number	ChemIDplus

Last Modified

16 March 2021