iclaprim (CHEBI:131724)

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ChEBI Name	iclaprim

ChEBI ID	CHEBI:131724

Definition	A racemate consisting of equimolar amounts of (R)- and (S)-iclaprim. Both enantiomers exhibit similar, potent bactericidal activity against major Gram-positive pathogens, notably methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA, respectively).

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Kevin

Wikipedia	License

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Formula

C19H22N4O3

Net Charge

Average Mass

354.404

Monoisotopic Mass

354.16919

Roles Classification
Biological Role(s):	EC 1.5.1.3 (dihydrofolate reductase) inhibitor An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3). antibacterial drug A drug used to treat or prevent bacterial infections.

Application(s):	antibacterial drug A drug used to treat or prevent bacterial infections.

ChEBI Ontology
Outgoing	iclaprim (CHEBI:131724) has part (R)-iclaprim (CHEBI:131752) iclaprim (CHEBI:131724) has part (S)-iclaprim (CHEBI:131753) iclaprim (CHEBI:131724) has role antibacterial drug (CHEBI:36047) iclaprim (CHEBI:131724) has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor (CHEBI:50683) iclaprim (CHEBI:131724) is a racemate (CHEBI:60911)

IUPAC Name

rac-5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine

Synonyms	Sources
5-((2RS)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-ylmethyl)pyrimidine-2,4-diamine	ChemIDplus
AR 100	ChemIDplus
AR-100	ChemIDplus

Last Modified

22 February 2017