brasixanthone B (CHEBI:65519)

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ChEBI Name	brasixanthone B

ChEBI ID	CHEBI:65519

Definition	A member of the class of pyranoxanthones that is 2H,6H-pyrano[3,2-b]xanthen-6-one substituted by hydroxy, geminal methyl and a prenyl group at positions 5, 8, 2 and 12 respectively. It is isolated from the stem bark of Calophyllum brasiliense and exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C23H22O5

Net Charge

Average Mass

378.41780

Monoisotopic Mass

378.14672

InChI

InChI=1S/C23H22O5/c1-12(2)5-7-15-21-14(9-10-23(3,4)28-21)19(25)18-20(26)16-11-13(24)6-8-17(16)27-22(15)18/h5-6,8-11,24-25H,7H2,1-4H3

InChIKey

BFPCRQCNDMJVOT-UHFFFAOYSA-N

SMILES

CC(C)=CCc1c2OC(C)(C)C=Cc2c(O)c2c1oc1ccc(O)cc1c2=O

Metabolite of Species	Details
Calophyllum brasiliense (IPNI:427115-1)	Found in stem (BTO:0001300). Previous component: stem bark; See: PubMed

Roles Classification
Biological Role(s):	metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	brasixanthone B (CHEBI:65519) has role antineoplastic agent (CHEBI:35610) brasixanthone B (CHEBI:65519) has role metabolite (CHEBI:25212) brasixanthone B (CHEBI:65519) is a polyphenol (CHEBI:26195) brasixanthone B (CHEBI:65519) is a pyranoxanthones (CHEBI:71238)

Synonyms	Sources
5,8-dihydroxy-2,2-dimethyl-12-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one	IUPAC
cudraxanthone Q	ChEBI

Registry Number	Type	Source
8800172	Reaxys Registry Number	Reaxys

Last Modified

27 November 2012