SCH-351591 (CHEBI:77774)

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ChEBI Name	SCH-351591

ChEBI ID	CHEBI:77774

Definition	An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C17H10Cl2F3N3O3

Net Charge

Average Mass

432.18100

Monoisotopic Mass

431.00513

InChI

InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26)

InChIKey

RUOGJYKOQBFJIG-UHFFFAOYSA-N

SMILES

COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F

Roles Classification
Biological Role(s):	phosphodiesterase IV inhibitor An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.

ChEBI Ontology
Outgoing	SCH-351591 (CHEBI:77774) has role phosphodiesterase IV inhibitor (CHEBI:68844) SCH-351591 (CHEBI:77774) is a aromatic amide (CHEBI:62733) SCH-351591 (CHEBI:77774) is a aromatic ether (CHEBI:35618) SCH-351591 (CHEBI:77774) is a chloropyridine (CHEBI:39173) SCH-351591 (CHEBI:77774) is a monocarboxylic acid amide (CHEBI:29347) SCH-351591 (CHEBI:77774) is a organofluorine compound (CHEBI:37143) SCH-351591 (CHEBI:77774) is a pyridine N-oxides (CHEBI:38189) SCH-351591 (CHEBI:77774) is a quinolines (CHEBI:26513)

IUPAC Name

N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide

Synonyms	Sources
8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide	ChEBI
N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide	ChemIDplus
Sch 351591	ChemIDplus
Sch-351591	ChemIDplus
SCH351591	ChEBI

Last Modified

19 March 2014