CHEBI:71219 - pazopanib

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name pazopanib
ChEBI ID CHEBI:71219
Definition A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C21H23N7O2S
Net Charge 0
Average Mass 437.520
Monoisotopic Mass 437.16339
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKey CUIHSIWYWATEQL-UHFFFAOYSA-N
SMILES C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing pazopanib (CHEBI:71219) has role angiogenesis modulating agent (CHEBI:50926)
pazopanib (CHEBI:71219) has role antineoplastic agent (CHEBI:35610)
pazopanib (CHEBI:71219) has role tyrosine kinase inhibitor (CHEBI:38637)
pazopanib (CHEBI:71219) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207)
pazopanib (CHEBI:71219) is a aminopyrimidine (CHEBI:38338)
pazopanib (CHEBI:71219) is a indazoles (CHEBI:38769)
pazopanib (CHEBI:71219) is a sulfonamide (CHEBI:35358)
pazopanib (CHEBI:71219) is conjugate base of pazopanib(1+) (CHEBI:71218)
Incoming pazopanib(1+) (CHEBI:71218) is conjugate acid of pazopanib (CHEBI:71219)
IUPAC Name
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
INNs Sources
pazopanib WHO MedNet
pazopanib WHO MedNet
pazopanib WHO MedNet
pazopanibum WHO MedNet
Synonyms Sources
GW 78603 ChemIDplus
GW786034 ChemIDplus
Manual Xrefs Databases
4118 DrugCentral
LSM-1114 LINCS
Pazopanib Wikipedia
US2008293691 Patent
WO2006020564 Patent
WO2007064753 Patent
WO2007143483 Patent
WO2011058179 Patent
WO2011069053 Patent
WO2011150044 Patent
WO2012106302 Patent
View more database links
Registry Numbers Types Sources
11646488 Reaxys Registry Number Reaxys
444731-52-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
21394443 PubMed citation Europe PMC
21766486 PubMed citation Europe PMC
21811833 PubMed citation Europe PMC
22112314 PubMed citation Europe PMC
22190407 PubMed citation Europe PMC
22233389 PubMed citation Europe PMC
22341567 PubMed citation Europe PMC
22359392 PubMed citation Europe PMC
22595799 PubMed citation Europe PMC
22679111 PubMed citation Europe PMC
22688250 PubMed citation Europe PMC
22716487 PubMed citation Europe PMC
22733110 PubMed citation Europe PMC
22733795 PubMed citation Europe PMC
22759480 PubMed citation Europe PMC
22766517 PubMed citation Europe PMC
22830347 PubMed citation Europe PMC
22861374 PubMed citation Europe PMC
22917595 PubMed citation Europe PMC
22984765 PubMed citation Europe PMC
23054212 PubMed citation Europe PMC
23064954 PubMed citation Europe PMC
23072642 PubMed citation Europe PMC
23088634 PubMed citation Europe PMC
23135778 PubMed citation Europe PMC
Last Modified
03 February 2020