robenacoxib (CHEBI:76269)

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ChEBI Name	robenacoxib

ChEBI ID	CHEBI:76269

Definition	An aromatic amino acid that is 2-amino-5-ethylphenylacetic acid in which one of the amino hydrogens is replaced by a 2,3,5,6-tetrafluorophenyl group. A selective cyclooxygenase 2 inhibitor that is used in veterinary medicine for the relief of pain and inflammation in cats and dogs.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C16H13F4NO2

Net Charge

Average Mass

327.27350

Monoisotopic Mass

327.08824

InChI

InChI=1S/C16H13F4NO2/c1-2-8-3-4-12(9(5-8)6-13(22)23)21-16-14(19)10(17)7-11(18)15(16)20/h3-5,7,21H,2,6H2,1H3,(H,22,23)

InChIKey

ZEXGDYFACFXQPF-UHFFFAOYSA-N

SMILES

CCc1ccc(Nc2c(F)c(F)cc(F)c2F)c(CC(O)=O)c1

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid ) Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. cyclooxygenase 2 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.

Application(s):	non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.

ChEBI Ontology
Outgoing	robenacoxib (CHEBI:76269) has role cyclooxygenase 2 inhibitor (CHEBI:50629) robenacoxib (CHEBI:76269) has role non-narcotic analgesic (CHEBI:35481) robenacoxib (CHEBI:76269) has role non-steroidal anti-inflammatory drug (CHEBI:35475) robenacoxib (CHEBI:76269) is a aromatic amino acid (CHEBI:33856) robenacoxib (CHEBI:76269) is a monocarboxylic acid (CHEBI:25384) robenacoxib (CHEBI:76269) is a organofluorine compound (CHEBI:37143) robenacoxib (CHEBI:76269) is a phenylacetic acids (CHEBI:25978) robenacoxib (CHEBI:76269) is a secondary amino compound (CHEBI:50995)

IUPAC Name

{5-ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]phenyl}acetic acid

Last Modified

23 December 2018