CHEBI:84507 - varenicline tartrate

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ChEBI Name varenicline tartrate
ChEBI ID CHEBI:84507
Definition A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H19N3O6
Net Charge 0
Average Mass 361.34930
Monoisotopic Mass 361.12739
InChI InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
InChIKey TWYFGYXQSYOKLK-LREBCSMRSA-N
SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.C1C2CNCC1c1cc3nccnc3cc21
Roles Classification
Biological Role(s): nicotinic acetylcholine receptor agonist
An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
Application(s): nicotinic acetylcholine receptor agonist
An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
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ChEBI Ontology
Outgoing varenicline tartrate (CHEBI:84507) has part varenicline(1+) (CHEBI:84508)
varenicline tartrate (CHEBI:84507) has role nicotinic acetylcholine receptor agonist (CHEBI:47958)
varenicline tartrate (CHEBI:84507) has role serotonergic agonist (CHEBI:35941)
varenicline tartrate (CHEBI:84507) is a tartrate salt (CHEBI:50562)
IUPAC Names
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8-ium (2R,3R)-3-carboxy-2,3-dihydroxypropanoate
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinic acid
Synonyms Sources
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutanedioate ChemIDplus
CP 526555-18 ChemIDplus
CP-526,555-18 ChemIDplus
varenicline monotartrate ChEBI
Brand Names Sources
Champix ChemIDplus
Chantix KEGG DRUG
Manual Xrefs Databases
D06282 KEGG DRUG
DB01273 DrugBank
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Registry Numbers Types Sources
14347664 Reaxys Registry Number Reaxys
375815-87-5 CAS Registry Number ChemIDplus
375815-87-5 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
22993168 PubMed citation Europe PMC
25013685 PubMed citation Europe PMC
25031315 PubMed citation Europe PMC
25545858 PubMed citation Europe PMC
Last Modified
26 January 2015