CHEBI:51141 - alfuzosin

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ChEBI Name alfuzosin
ChEBI ID CHEBI:51141
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H27N5O4
Net Charge 0
Average Mass 389.44898
Monoisotopic Mass 389.20630
InChI InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
InChIKey WNMJYKCGWZFFKR-UHFFFAOYSA-N
SMILES COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1
Roles Classification
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
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ChEBI Ontology
Outgoing alfuzosin (CHEBI:51141) has role α-adrenergic antagonist (CHEBI:37890)
alfuzosin (CHEBI:51141) has role antihypertensive agent (CHEBI:35674)
alfuzosin (CHEBI:51141) has role antineoplastic agent (CHEBI:35610)
alfuzosin (CHEBI:51141) is a monocarboxylic acid amide (CHEBI:29347)
alfuzosin (CHEBI:51141) is a quinazolines (CHEBI:38530)
alfuzosin (CHEBI:51141) is a tetrahydrofuranol (CHEBI:47017)
Incoming alfuzosin hydrochloride (CHEBI:32286) has part alfuzosin (CHEBI:51141)
IUPAC Name
N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
INNs Sources
alfuzosin WHO MedNet
alfuzosina WHO MedNet
alfuzosine WHO MedNet
alfuzosinum WHO MedNet
Manual Xrefs Databases
115 DrugCentral
Alfuzosin Wikipedia
D07124 KEGG DRUG
DB00346 DrugBank
DE2904445 Patent
LSM-1291 LINCS
US4315007 Patent
View more database links
Registry Number Type Source
81403-80-7 CAS Registry Number ChemIDplus
Last Modified
22 February 2017