NS 1619 (CHEBI:34879)

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ChEBI Name	NS 1619

ChEBI ID	CHEBI:34879

Definition	A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C15H8F6N2O2

Net Charge

Average Mass

362.22660

Monoisotopic Mass

362.04900

InChI

InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

InChIKey

YLFMCMWKHSDUCT-UHFFFAOYSA-N

SMILES

Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F

Roles Classification
Biological Role(s):	potassium channel opener A potassium channel modulator that opens the potassium channel.

ChEBI Ontology
Outgoing	NS 1619 (CHEBI:34879) has role potassium channel opener (CHEBI:79085) NS 1619 (CHEBI:34879) is a (trifluoromethyl)benzenes (CHEBI:83565) NS 1619 (CHEBI:34879) is a benzimidazoles (CHEBI:22715) NS 1619 (CHEBI:34879) is a phenols (CHEBI:33853)

IUPAC Name

1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one

Synonyms	Sources
1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one	ChEBI
1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone	ChemIDplus
5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole	ChEBI
NS-1619	ChemIDplus
NS1619	ChEBI

Last Modified

25 February 2016