CHEBI:64202 - methiothepin maleate

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name methiothepin maleate
ChEBI ID CHEBI:64202
Definition A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
more structures >>
Formula C24H28N2O4S2
Net Charge 0
Average Mass 472.62000
Monoisotopic Mass 472.14905
InChI InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey IWDBEHWZGDSFHR-BTJKTKAUSA-N
SMILES OC(=O)\C=C/C(O)=O.CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Roles Classification
Biological Role(s): serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Application(s): serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
antipsychotic agent
Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing methiothepin maleate (CHEBI:64202) has part methiothepin(2+) (CHEBI:64204)
methiothepin maleate (CHEBI:64202) has role antipsychotic agent (CHEBI:35476)
methiothepin maleate (CHEBI:64202) has role dopaminergic antagonist (CHEBI:48561)
methiothepin maleate (CHEBI:64202) has role serotonergic antagonist (CHEBI:48279)
methiothepin maleate (CHEBI:64202) is a maleate salt (CHEBI:50221)
IUPAC Name
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (2Z)-but-2-enedioate
Synonyms Sources
1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine maleate ChemIDplus
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine maleate ChEBI
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazinediium (2Z)-but-2-enedioate IUPAC
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (2Z)-but-2-enedioate ChEBI
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine maleate ChEBI
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazinediium (2Z)-but-2-enedioate ChEBI
8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin maleate ChemIDplus
Metitepine maleate ChemIDplus
Registry Numbers Types Sources
19728-88-2 CAS Registry Number ChemIDplus
4119981 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
18480175 PubMed citation Europe PMC
2138403 PubMed citation Europe PMC
2142373 PubMed citation Europe PMC
554040 PubMed citation Europe PMC
6448038 PubMed citation Europe PMC
Last Modified
16 March 2012