Src Inhibitor-1 (CHEBI:78332)

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ChEBI Name	Src Inhibitor-1

ChEBI ID	CHEBI:78332

Definition	A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Margaret Duesbury

Supplier Information

Download	Molfile XML SDF

Formula

C22H19N3O3

Net Charge

Average Mass

373.40460

Monoisotopic Mass

373.14264

InChI

InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)

InChIKey

DMWVGXGXHPOEPT-UHFFFAOYSA-N

SMILES

COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).

ChEBI Ontology
Outgoing	Src Inhibitor-1 (CHEBI:78332) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) Src Inhibitor-1 (CHEBI:78332) is a aromatic ether (CHEBI:35618) Src Inhibitor-1 (CHEBI:78332) is a polyether (CHEBI:46774) Src Inhibitor-1 (CHEBI:78332) is a quinazolines (CHEBI:38530) Src Inhibitor-1 (CHEBI:78332) is a secondary amino compound (CHEBI:50995)

IUPAC Name

6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine

Synonyms	Sources
(4'-oxyphenyl-phenylamino)-6,7-dimethoxyquinazoline	ChEBI
4-(4'-phenoxyanilino)-6,7-dimethoxyquinazoline	ChEBI
6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine	ChEBI
SKI-1	ChEBI
Src kinase inhibitor I	ChEBI
Src-l1	ChEBI

Registry Number	Type	Source
8790191	Reaxys Registry Number	Reaxys

Citation	Type	Source
17850214	PubMed citation	Europe PMC

Last Modified

25 February 2016