2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine

ChEBI ID	CHEBI:143120

ChEBI ASCII Name	2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine

Definition	A member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by 6-methylpyridin-2-yl and pyridin-4-ylnitrilo groups, respectively. It is an ALK5 and PKN3 kinase inhibitor.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Tim Willson

Supplier Information

Download	Molfile XML SDF

Formula

C19H15N5

Net Charge

Average Mass

313.364

Monoisotopic Mass

313.13275

InChI

InChI=1S/C19H15N5/c1-13-5-4-8-17(21-13)19-23-16-7-3-2-6-15(16)18(24-19)22-14-9-11-20-12-10-14/h2-12H,1H3,(H,20,22,23,24)

InChIKey

JONFDFIXMPXTRH-UHFFFAOYSA-N

SMILES

CC1=CC=CC(C2=NC3=CC=CC=C3C(NC4=CC=NC=C4)=N2)=N1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30). EC 2.7.11.13 (protein kinase C) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).

ChEBI Ontology
Outgoing	2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) has role EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor (CHEBI:137123) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a aromatic amine (CHEBI:33860) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a methylpyridines (CHEBI:25340) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a pyridines (CHEBI:26421) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a quinazolines (CHEBI:38530) 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a secondary amino compound (CHEBI:50995)

IUPAC Name

2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine

Synonym	Source
GW855857	ChEBI

Citation	Type	Source
19285388	PubMed citation	Europe PMC

Last Modified

12 March 2019