CHEBI:63625 - tenofovir (anhydrous)

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ChEBI Name tenofovir (anhydrous) ChEBI ID CHEBI:63625 Definition A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. Stars This entity has been manually annotated by the ChEBI Team. Submitter Anonymous Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C9H14N5O4P Net Charge 0 Average Mass 287.21230 Monoisotopic Mass 287.07834 InChI InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1 InChIKey SGOIRFVFHAKUTI-ZCFIWIBFSA-N SMILES C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O Roles Classification Biological Role(s): drug metabolite HIV-1 reverse transcriptase inhibitor An entity which inhibits the activity of HIV-1 reverse transcriptase. antiviral drug A substance used in the prophylaxis or therapy of virus diseases. Application(s): antiviral drug A substance used in the prophylaxis or therapy of virus diseases. View more via ChEBI Ontology ChEBI Ontology Outgoing tenofovir (anhydrous) (CHEBI:63625) has role antiviral drug (CHEBI:36044) tenofovir (anhydrous) (CHEBI:63625) has role drug metabolite (CHEBI:49103) tenofovir (anhydrous) (CHEBI:63625) has role HIV-1 reverse transcriptase inhibitor (CHEBI:53756) tenofovir (anhydrous) (CHEBI:63625) is a nucleoside analogue (CHEBI:60783) tenofovir (anhydrous) (CHEBI:63625) is a phosphonic acids (CHEBI:26069) tenofovir (anhydrous) (CHEBI:63625) is conjugate acid of tenofovir(1−) (CHEBI:134504) Incoming tenofovir disoproxil (CHEBI:63717) has functional parent tenofovir (anhydrous) (CHEBI:63625) tenofovir hydrate (CHEBI:63716) has part tenofovir (anhydrous) (CHEBI:63625) tenofovir(1−) (CHEBI:134504) is conjugate base of tenofovir (anhydrous) (CHEBI:63625) IUPAC Name ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid INN Source tenofovir ChemIDplus Synonyms Sources (R)-PMPA ChEBI anh. tenofovir ChEBI anhydrous tenofovir ChEBI tenofovir (anh.) ChEBI Manual Xrefs Databases D06074 KEGG DRUG DB00300 DrugBank HMDB0014445 HMDB LSM-5340 LINCS Tenofovir Wikipedia View more database links Registry Numbers Types Sources 147127-20-6 CAS Registry Number ChemIDplus 7415378 Reaxys Registry Number Reaxys Citations Types Sources 11777298 PubMed citation Europe PMC 25017682 PubMed citation Europe PMC 28166217 PubMed citation Europe PMC 28503983 PubMed citation Europe PMC Last Modified 19 June 2017