CHEBI:85267 - flumequine

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ChEBI Name flumequine
ChEBI ID CHEBI:85267
Definition A racemate comprising equimolar amounts of R- and S-flumequine. A broad-spectrum antibiotic, formerly used in veterinary medicine for stock breeding and treatment of aquacultures.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
topoisomerase IV inhibitor
A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
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ChEBI Ontology
Outgoing flumequine (CHEBI:85267) has part (R)-flumequine (CHEBI:85273)
flumequine (CHEBI:85267) has part (S)-flumequine (CHEBI:85272)
flumequine (CHEBI:85267) has role antimicrobial agent (CHEBI:33281)
flumequine (CHEBI:85267) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750)
flumequine (CHEBI:85267) has role environmental contaminant (CHEBI:78298)
flumequine (CHEBI:85267) has role topoisomerase IV inhibitor (CHEBI:53559)
flumequine (CHEBI:85267) has role xenobiotic (CHEBI:35703)
flumequine (CHEBI:85267) is a racemate (CHEBI:60911)
IUPAC Name
rac-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
INNs Sources
flumequine KEGG DRUG
flumequino ChemIDplus
flumequinum ChemIDplus
Synonym Source
9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid ChemIDplus
Manual Xrefs Databases
1564 VSDB
D02302 KEGG DRUG
Flumequine Wikipedia
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Registry Numbers Types Sources
42835-25-6 CAS Registry Number ChemIDplus
42835-25-6 CAS Registry Number KEGG DRUG
490724 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
23773949 PubMed citation Europe PMC
24261869 PubMed citation Europe PMC
24836135 PubMed citation Europe PMC
25045079 PubMed citation Europe PMC
25476307 PubMed citation Europe PMC
25633214 PubMed citation Europe PMC
Last Modified
19 September 2018