CHEBI:77543 - ebselen

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ChEBI Name ebselen
ChEBI ID CHEBI:77543
Definition A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Maria Costanzo
Supplier Information
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Formula C13H9NOSe
Net Charge 0
Average Mass 274.18000
Monoisotopic Mass 274.98494
InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChIKey DYEFUKCXAQOFHX-UHFFFAOYSA-N
SMILES O=c1n([se]c2ccccc12)-c1ccccc1
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
Biological Role(s): EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor
An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP+), EC 1.3.1.8.
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12).
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7).
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
EC 3.5.4.1 (cytosine deaminase) inhibitor
An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of cytosine deaminase (EC 3.5.4.1).
EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor
An EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor that interferes with the action of UDP-glucose 4-epimerase (EC 5.1.3.2).
antibacterial agent
A substance (or active part thereof) that kills or slows the growth of bacteria.
EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor
An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of inositol-phosphate phosphatase (EC 3.1.3.25).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
genotoxin
A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
ferroptosis inhibitor
Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
anti-inflammatory drug
A substance that reduces or suppresses inflammation.
hepatoprotective agent
Any compound that is able to prevent damage to the liver.
enzyme mimic
Any small molecule that mimics the action of an enzyme.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ebselen (CHEBI:77543) has role anti-inflammatory drug (CHEBI:35472)
ebselen (CHEBI:77543) has role antibacterial agent (CHEBI:33282)
ebselen (CHEBI:77543) has role anticoronaviral agent (CHEBI:149553)
ebselen (CHEBI:77543) has role antifungal agent (CHEBI:35718)
ebselen (CHEBI:77543) has role antineoplastic agent (CHEBI:35610)
ebselen (CHEBI:77543) has role antioxidant (CHEBI:22586)
ebselen (CHEBI:77543) has role apoptosis inducer (CHEBI:68495)
ebselen (CHEBI:77543) has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor (CHEBI:64996)
ebselen (CHEBI:77543) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964)
ebselen (CHEBI:77543) has role EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP+)] inhibitor (CHEBI:78377)
ebselen (CHEBI:77543) has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor (CHEBI:77402)
ebselen (CHEBI:77543) has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor (CHEBI:78379)
ebselen (CHEBI:77543) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
ebselen (CHEBI:77543) has role EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor (CHEBI:173094)
ebselen (CHEBI:77543) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285)
ebselen (CHEBI:77543) has role EC 3.5.4.1 (cytosine deaminase) inhibitor (CHEBI:78380)
ebselen (CHEBI:77543) has role EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor (CHEBI:78384)
ebselen (CHEBI:77543) has role enzyme mimic (CHEBI:78152)
ebselen (CHEBI:77543) has role ferroptosis inhibitor (CHEBI:173084)
ebselen (CHEBI:77543) has role genotoxin (CHEBI:50902)
ebselen (CHEBI:77543) has role hepatoprotective agent (CHEBI:62868)
ebselen (CHEBI:77543) has role neuroprotective agent (CHEBI:63726)
ebselen (CHEBI:77543) has role radical scavenger (CHEBI:48578)
ebselen (CHEBI:77543) is a benzoselenazole (CHEBI:78151)
IUPAC Name
2-phenyl-1,2-benzoselenazol-3(2H)-one
INNs Sources
ebselen WHO MedNet
ebsélène WHO MedNet
ebseleno WHO MedNet
ebselenum WHO MedNet
Synonyms Sources
2-phenyl-1,2-benzoselenazol-3-one SUBMITTER
DR-3305 LINCS
DR3305 LINCS
PZ 51 ChemIDplus
SPI-1005 ChemIDplus
Manual Xrefs Databases
3082 ChemSpider
DB12610 DrugBank
Ebselen Wikipedia
LSM-2644 LINCS
View more database links
Registry Numbers Types Sources
164926 Reaxys Registry Number Reaxys
60940-34-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
26 May 2021