JWH-133 (CHEBI:146243)

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ChEBI Name	JWH-133

ChEBI ID	CHEBI:146243

Definition	A dibenzopyran that is Δ⁹-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB₂ receptor agonist.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

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Formula

C22H32O

Net Charge

Average Mass

312.497

Monoisotopic Mass

312.24532

InChI

InChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1

InChIKey

YSBFLLZNALVODA-RBUKOAKNSA-N

SMILES

C=1C(=CC2=C(C1)[C@]3([C@](C(O2)(C)C)(CC=C(C3)C)[H])[H])C(CCC)(C)C

Roles Classification
Biological Role(s):	CB2 receptor agonist A cannabinoid receptor agonist that binds to and activates type 2 cannabinoid receptors. apoptosis inhibitor Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. vasodilator agent A drug used to cause dilation of the blood vessels. anti-inflammatory agent Any compound that has anti-inflammatory effects. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. opioid analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.

ChEBI Ontology
Outgoing	JWH-133 (CHEBI:146243) has role analgesic (CHEBI:35480) JWH-133 (CHEBI:146243) has role anti-inflammatory agent (CHEBI:67079) JWH-133 (CHEBI:146243) has role antineoplastic agent (CHEBI:35610) JWH-133 (CHEBI:146243) has role apoptosis inhibitor (CHEBI:68494) JWH-133 (CHEBI:146243) has role CB₂ receptor agonist (CHEBI:146246) JWH-133 (CHEBI:146243) has role opioid analgesic (CHEBI:35482) JWH-133 (CHEBI:146243) has role vasodilator agent (CHEBI:35620) JWH-133 (CHEBI:146243) is a benzochromene (CHEBI:38920) JWH-133 (CHEBI:146243) is a dibenzopyran (CHEBI:39203) JWH-133 (CHEBI:146243) is a organic heterotricyclic compound (CHEBI:26979)

IUPAC Name

(6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene

Synonyms	Sources
(6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran	SUBMITTER
(6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene	IUPAC
1,1-dimethylbutyl-1-deoxy-Δ⁹-THC	ChemIDplus
JW 133	ChemIDplus
JWH 133	SUBMITTER
JWH133	ChEBI

Registry Number	Type	Source
259869-55-1	CAS Registry Number	ChemIDplus

Last Modified

03 March 2020