1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936)

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ChEBI Name	1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea

ChEBI ID	CHEBI:140936

Definition	A member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT_2B) receptor.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

Supplier Information

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Formula

C14H14N4OS

Net Charge

Average Mass

286.354

Monoisotopic Mass

286.08883

InChI

InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChIKey

USFUFHFQWXDVMH-UHFFFAOYSA-N

SMILES

S1N=C(C=C1NC(=O)NC2=CC3=C(N(C=C3)C)C=C2)C

Roles Classification
Biological Role(s):	serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

Application(s):	receptor modulator A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology
Outgoing	1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role receptor modulator (CHEBI:90710) 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role serotonergic antagonist (CHEBI:48279) 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a 1,2-thiazoles (CHEBI:48902) 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a indoles (CHEBI:24828) 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a ureas (CHEBI:47857)

IUPAC Name

1-(1-methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea

Synonyms	Sources
3-(3-methyl-1,2-thiazol-5-yl)-1-(1-methylindol-5-yl)urea	SUBMITTER
N-(1-methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	SUBMITTER
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	ChEBI
SB 204741	ChEBI
SB-204741	ChEBI
SB204741	ChEBI

Registry Number	Type	Source
152239-46-8	CAS Registry Number	SUBMITTER

Last Modified

05 June 2018