ethosuximide (CHEBI:4887)

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ChEBI Name	ethosuximide

ChEBI ID	CHEBI:4887

Definition	A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.

Stars	This entity has been manually annotated by the ChEBI Team.

Secondary ChEBI IDs	CHEBI:131811

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Formula

C7H11NO2

Net Charge

Average Mass

141.16770

Monoisotopic Mass

141.07898

InChI

InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChIKey

HAPOVYFOVVWLRS-UHFFFAOYSA-N

SMILES

CCC1(C)CC(=O)NC1=O

Roles Classification
Biological Role(s):	T-type calcium channel blocker Any agent that interferes with the activity of T-type calcium channels.

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. anticonvulsant A drug used to prevent seizures or reduce their severity.

ChEBI Ontology
Outgoing	ethosuximide (CHEBI:4887) has role anticonvulsant (CHEBI:35623) ethosuximide (CHEBI:4887) has role geroprotector (CHEBI:176497) ethosuximide (CHEBI:4887) has role T-type calcium channel blocker (CHEBI:194338) ethosuximide (CHEBI:4887) is a dicarboximide (CHEBI:35356) ethosuximide (CHEBI:4887) is a pyrrolidinone (CHEBI:38275)

Incoming	(R)-ethosuximide (CHEBI:60354) is a ethosuximide (CHEBI:4887) (S)-ethosuximide (CHEBI:60355) is a ethosuximide (CHEBI:4887)

IUPAC Name

3-ethyl-3-methylpyrrolidine-2,5-dione

Synonyms	Sources
(±)-2-ethyl-2-methylsuccinimide	ChemIDplus
2-ethyl-2-methylsuccinimide	ChemIDplus
2-methyl-2-ethylsuccinimide	ChemIDplus
3-ethyl-3-methyl-2,5-pyrrolidinedione	ChEBI
3-ethyl-3-methylsuccinimide	ChemIDplus
3-methyl-3-ethylpyrrolidine-2,5-dione	ChemIDplus
3-methyl-3-ethylsuccinimide	ChemIDplus
Aethosuximide	ChemIDplus
α-ethyl-α-methylsuccinimide	ChemIDplus
α-methyl-α-ethylsuccinimide	ChemIDplus
Ethosuximide	KEGG COMPOUND
γ-ethyl-γ-methyl-succinimide	ChEBI
γ-methyl-γ-ethyl-succinimide	ChemIDplus

Last Modified

07 February 2023