naproxen sodium (CHEBI:7477)

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ChEBI Name	naproxen sodium

ChEBI ID	CHEBI:7477

Definition	An organic sodium salt consisting of equimolar amounts of naproxen(1−) anions and sodium anions.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formulae

C14H13NaO3
C14H13O3.Na

Net Charge

Average Mass

252.24100

Monoisotopic Mass

252.07624

InChI

InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChIKey

CDBRNDSHEYLDJV-FVGYRXGTSA-M

SMILES

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

Roles Classification
Biological Role(s):	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. cyclooxygenase 2 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2. cyclooxygenase 1 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.

Application(s):	non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.

ChEBI Ontology
Outgoing	naproxen sodium (CHEBI:7477) has part naproxen(1−) (CHEBI:59527) naproxen sodium (CHEBI:7477) has role antipyretic (CHEBI:35493) naproxen sodium (CHEBI:7477) has role cyclooxygenase 1 inhibitor (CHEBI:50630) naproxen sodium (CHEBI:7477) has role cyclooxygenase 2 inhibitor (CHEBI:50629) naproxen sodium (CHEBI:7477) has role non-narcotic analgesic (CHEBI:35481) naproxen sodium (CHEBI:7477) has role non-steroidal anti-inflammatory drug (CHEBI:35475) naproxen sodium (CHEBI:7477) is a organic sodium salt (CHEBI:38700)

IUPAC Name

sodium (2S)-2-(6-methoxy-2-naphthyl)propanoate

Synonym	Source
(−)-Sodium (S)-6-methoxy-α-methyl-2-naphthaleneacetate	ChemIDplus

Last Modified

21 August 2017