CHEBI:50268 - GABA modulator

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ChEBI Name GABA modulator ChEBI ID CHEBI:50268 Definition A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. Stars This entity has been manually annotated by the ChEBI Team. ChEBI Ontology Outgoing GABA modulator (CHEBI:50268) is a GABA agent (CHEBI:51374) GABA modulator (CHEBI:50268) is a membrane transport modulator (CHEBI:38632) Incoming α-asarone (CHEBI:78309) has role GABA modulator (CHEBI:50268) β-asarone (CHEBI:10353) has role GABA modulator (CHEBI:50268) 5α-dihydrodeoxycorticosterone (CHEBI:81468) has role GABA modulator (CHEBI:50268) barbiturates (CHEBI:22693) has role GABA modulator (CHEBI:50268) benzodiazepine (CHEBI:22720) has role GABA modulator (CHEBI:50268) brexanolone (CHEBI:50169) has role GABA modulator (CHEBI:50268) clobazam (CHEBI:31413) has role GABA modulator (CHEBI:50268) clonazepam (CHEBI:3756) has role GABA modulator (CHEBI:50268) clorazepic acid (CHEBI:3761) has role GABA modulator (CHEBI:50268) dipotassium clorazepate (CHEBI:3762) has role GABA modulator (CHEBI:50268) estazolam (CHEBI:4858) has role GABA modulator (CHEBI:50268) isoliquiritigenin (CHEBI:310312) has role GABA modulator (CHEBI:50268) nimetazepam (CHEBI:31912) has role GABA modulator (CHEBI:50268) nitrazepam (CHEBI:7581) has role GABA modulator (CHEBI:50268) nordazepam (CHEBI:111762) has role GABA modulator (CHEBI:50268) pinocarveol (CHEBI:26137) has role GABA modulator (CHEBI:50268) secobarbital (CHEBI:9073) has role GABA modulator (CHEBI:50268) secobarbital sodium (CHEBI:32124) has role GABA modulator (CHEBI:50268) valerenic acid (CHEBI:9921) has role GABA modulator (CHEBI:50268) verruculogen (CHEBI:72765) has role GABA modulator (CHEBI:50268) zuranolone (CHEBI:228302) has role GABA modulator (CHEBI:50268) Synonym Source GABA modulators ChEBI Last Modified 21 December 2023