CHEBI:149761 - zolasartan

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ChEBI Name zolasartan
ChEBI ID CHEBI:149761
Definition A member of the class of 1-benzofurans that is 3-bromo-1-benzofuran which is substituted by a 2-(1H-tetrazol-5-yl)phenyl group at position 2 and by a (2-butyl-5-carboxy-4-chloro-1H-imidazol-1-yl)methyl group at position 5. It is an angiotensin II receptor type 1 (AT1) antagonist and was in clinical trials for the treatment of hypertension (now discontinued).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C24H20BrClN6O3
Net Charge 0
Average Mass 555.820
Monoisotopic Mass 554.04688
InChI InChI=1S/C24H20BrClN6O3/c1-2-3-8-18-27-22(26)20(24(33)34)32(18)12-13-9-10-17-16(11-13)19(25)21(35-17)14-6-4-5-7-15(14)23-28-30-31-29-23/h4-7,9-11H,2-3,8,12H2,1H3,(H,33,34)(H,28,29,30,31)
InChIKey FIKYECRHLXONOX-UHFFFAOYSA-N
SMILES C=1(C2=CC=CC=C2C3=NN=NN3)OC=4C=CC(=CC4C1Br)CN5C(=NC(=C5C(O)=O)Cl)CCCC
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
Application(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing zolasartan (CHEBI:149761) has role angiotensin receptor antagonist (CHEBI:61016)
zolasartan (CHEBI:149761) has role antihypertensive agent (CHEBI:35674)
zolasartan (CHEBI:149761) is a 1-benzofurans (CHEBI:38830)
zolasartan (CHEBI:149761) is a biaryl (CHEBI:64459)
zolasartan (CHEBI:149761) is a imidazolyl carboxylic acid (CHEBI:38307)
zolasartan (CHEBI:149761) is a monocarboxylic acid (CHEBI:25384)
zolasartan (CHEBI:149761) is a organobromine compound (CHEBI:37141)
zolasartan (CHEBI:149761) is a organochlorine compound (CHEBI:36683)
zolasartan (CHEBI:149761) is a tetrazoles (CHEBI:35689)
zolasartan (CHEBI:149761) is conjugate acid of zolasartan(2−) (CHEBI:149524)
Incoming zolasartan(2−) (CHEBI:149524) is conjugate base of zolasartan (CHEBI:149761)
IUPAC Name
1-({3-bromo-2-[2-(1H-tetrazol-5-yl)phenyl]-1-benzofuran-5-yl}methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
INNs Sources
zolasartan WHO MedNet
zolasartan WHO MedNet
zolasartán WHO MedNet
zolasartanum WHO MedNet
Synonyms Sources
1-((3-bromo-2-(o-1H-tetrazol-5-ylphenyl)-5-benzofuranyl)methyl)-2-butyl-4-chloroimidazole-5-carboxylic acid ChEBI
GR 117289 ChemIDplus
GR 117289C ChemIDplus
GR-117289 ChEBI
GR-117289C ChEBI
GR117289 ChEBI
GR117289C ChEBI
Registry Number Type Source
145781-32-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10473295 PubMed citation Europe PMC
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8469769 PubMed citation Europe PMC
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8836613 PubMed citation Europe PMC
9088589 PubMed citation Europe PMC
Last Modified
19 May 2020