CHEBI:145537 - AMG-925

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ChEBI Name AMG-925
ChEBI ID CHEBI:145537
Definition An organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C26H29N7O2
Net Charge 0
Average Mass 471.565
Monoisotopic Mass 471.23827
InChI InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)/t16-,18-
InChIKey BBUVDDPUURMFOX-SAABIXHNSA-N
SMILES C=12N=C(N=CC1C3=C(N2[C@@H]4CC[C@H](CC4)C)C=NC=C3)NC=5C=CC6=C(N5)CCN(C6)C(CO)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing AMG-925 (CHEBI:145537) has role antineoplastic agent (CHEBI:35610)
AMG-925 (CHEBI:145537) has role apoptosis inducer (CHEBI:68495)
AMG-925 (CHEBI:145537) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
AMG-925 (CHEBI:145537) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
AMG-925 (CHEBI:145537) is a naphthyridine derivative (CHEBI:73539)
AMG-925 (CHEBI:145537) is a organic heterotricyclic compound (CHEBI:26979)
AMG-925 (CHEBI:145537) is a primary α-hydroxy ketone (CHEBI:139590)
AMG-925 (CHEBI:145537) is a secondary amino compound (CHEBI:50995)
AMG-925 (CHEBI:145537) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
2-hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone
Synonyms Sources
2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethan-1-one IUPAC
AMG 925 ChEBI
AMG-925 ChEBI
AMG925 ChEBI
FLX 925 ChEBI
FLX-925 ChEBI
FLX925 ChEBI
Manual Xref Database
US8623885 Patent
View more database links
Registry Number Type Source
1401033-86-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
24526162 PubMed citation Europe PMC
24641103 PubMed citation Europe PMC
25326874 PubMed citation Europe PMC
25487917 PubMed citation Europe PMC
26802152 PubMed citation Europe PMC
30514344 PubMed citation Europe PMC
Last Modified
28 November 2019