dipotassium clorazepate (CHEBI:3762)

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ChEBI Name	dipotassium clorazepate

ChEBI ID	CHEBI:3762

Definition	The compound of monopotassium clorazepate with potassium hydroxide. It is used for the management of anxiety disorders, for the short-term relief of anxiety, as adjunctive therapy in the management of epilepsy, and for the symptomatic relief of acute alcohol withdrawal.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

C16H11ClK2N2O4

Net Charge

Average Mass

408.91900

Monoisotopic Mass

407.96815

InChI

InChI=1S/C16H11ClN2O3.2K.H2O/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12;;;/h1-8,14H,(H,18,20)(H,21,22);;;1H2/q;2*+1;/p-2

InChIKey

QCHSEDTUUKDTIG-UHFFFAOYSA-L

SMILES

[OH-].[K+].[K+].[O-]C(=O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O

Roles Classification
Biological Role(s):	GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.

Application(s):	prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. anticonvulsant A drug used to prevent seizures or reduce their severity. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.

ChEBI Ontology
Outgoing	dipotassium clorazepate (CHEBI:3762) has part clorazepate monopotassium (CHEBI:59591) dipotassium clorazepate (CHEBI:3762) has role anticonvulsant (CHEBI:35623) dipotassium clorazepate (CHEBI:3762) has role anxiolytic drug (CHEBI:35474) dipotassium clorazepate (CHEBI:3762) has role GABA modulator (CHEBI:50268) dipotassium clorazepate (CHEBI:3762) has role prodrug (CHEBI:50266) dipotassium clorazepate (CHEBI:3762) is a potassium salt (CHEBI:26218)

IUPAC Name

dipotassium 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate hydroxide

Last Modified

08 June 2010