Ketcher 11161715552D 1 1.00000 0.00000 0 31 35 0 0 0 999 V2000 4.7115 -8.8779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5776 -9.3780 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5776 -10.3780 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8454 -10.3780 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8454 -9.3780 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7115 -10.8780 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7115 -7.8779 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5287 -10.6870 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8377 -11.6381 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1164 -9.8780 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5287 -9.0689 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4775 -6.4236 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4558 -6.2157 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1249 -6.9588 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8159 -7.9099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8377 -8.1178 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1685 -7.3746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4850 -8.6530 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 7.9558 -5.3496 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0385 -6.5521 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9340 -5.5575 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5490 -4.4360 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1369 -3.6270 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6408 -4.4867 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6409 -4.4823 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1370 -3.6140 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6331 -2.7502 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6331 -2.7546 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1369 -3.6229 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1447 -5.3461 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5503 -4.4337 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 2 3 2 0 0 0 4 5 1 0 0 0 5 1 2 0 0 0 6 4 2 0 0 0 6 3 1 0 0 0 7 1 1 0 0 0 3 8 1 0 0 0 8 9 1 0 0 0 10 8 1 0 0 0 2 11 1 0 0 0 11 10 2 0 0 0 12 13 2 0 0 0 13 14 1 0 0 0 14 15 2 0 0 0 15 16 1 0 0 0 16 17 2 0 0 0 17 12 1 0 0 0 11 16 1 0 0 0 15 18 1 0 0 0 13 19 1 0 0 0 14 20 1 0 0 0 20 21 1 0 0 0 19 21 1 0 0 0 19 22 1 0 0 0 22 23 1 0 0 0 24 25 2 0 0 0 25 26 1 0 0 0 26 27 2 0 0 0 27 28 1 0 0 0 28 29 2 0 0 0 29 24 1 0 0 0 23 29 1 0 0 0 25 30 1 0 0 0 22 31 2 0 0 0 M END > CHEBI:139047 > GSK2656157 > A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor. > 3 > PERK inhibitor; 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone > 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone > C23H21FN6O > 416.452 > 416.17609 > 0 > C=1(C2=C(N=CN1)N(C)C=C2C=3C(=C4C(=CC3)N(CC4)C(CC5=CC=CC(=N5)C)=O)F)N > InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27) > PRWSIEBRGXYXAJ-UHFFFAOYSA-N > 1337532-29-2 > 21981813 > 23333938; 24401334; 24900593; 27251848; 27682474; 28212323; 28452996; 28522733; 28641278; 28672279; 28686850; 28763567; 28867195 $$$$