Mrv0541 12051312132D 60 64 0 0 0 0 999 V2000 6.5501 -9.8174 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2175 -10.3023 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0021 -10.0473 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8356 -8.5799 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5501 -8.9924 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1376 -11.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8826 -10.3023 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9626 -11.0869 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5855 -11.7000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0756 -10.1308 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7786 -11.5285 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5236 -10.7439 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7166 -10.5723 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1646 -11.1854 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8356 -7.7549 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.1211 -8.9924 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.3738 -11.7860 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1987 -11.7971 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6016 -12.5170 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4265 -12.5280 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8486 -11.8191 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4456 -11.0992 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6207 -11.0882 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6735 -11.8301 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9518 -12.4949 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.1198 -7.3496 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1198 -6.5246 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8343 -6.1121 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5487 -6.5246 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2632 -6.1121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2632 -5.2871 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5487 -4.8746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8343 -5.2871 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9777 -4.8746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9777 -4.0496 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6922 -3.6371 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6922 -2.8121 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4066 -2.3996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1211 -2.8121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8356 -2.3996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5500 -2.8121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2645 -2.3996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9790 -2.8121 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 13.6935 -2.3996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4079 -2.8121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4066 -1.5746 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.5500 -3.6371 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8356 -4.0496 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8356 -4.8746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1211 -5.2871 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1211 -6.1121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8356 -6.5246 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5500 -6.1121 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5500 -5.2871 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1211 -3.6371 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2645 -1.5746 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9790 -3.6371 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6935 -4.0496 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6935 -4.8746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4058 -3.6383 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9 11 2 0 0 0 0 10 12 2 0 0 0 0 12 13 1 0 0 0 0 13 14 1 0 0 0 0 11 12 1 0 0 0 0 4 5 1 0 0 0 0 4 15 1 0 0 0 0 5 1 1 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 6 7 2 0 0 0 0 6 8 1 0 0 0 0 6 9 1 0 0 0 0 7 1 1 0 0 0 0 7 10 1 0 0 0 0 8 2 1 0 0 0 0 4 16 2 0 0 0 0 8 17 1 0 0 0 0 17 18 1 0 0 0 0 18 19 2 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 23 2 0 0 0 0 18 23 1 0 0 0 0 21 24 1 0 0 0 0 17 25 2 0 0 0 0 15 26 1 0 0 0 0 35 36 1 0 0 0 0 36 37 1 0 0 0 0 37 38 1 0 0 0 0 38 39 1 0 0 0 0 39 40 1 0 0 0 0 40 41 1 0 0 0 0 41 42 1 0 0 0 0 42 43 1 0 0 0 0 43 44 1 0 0 0 0 44 45 1 0 0 0 0 38 46 2 0 0 0 0 41 47 1 0 0 0 0 47 48 1 0 0 0 0 48 49 1 0 0 0 0 49 50 2 0 0 0 0 50 51 1 0 0 0 0 51 52 2 0 0 0 0 52 53 1 0 0 0 0 53 54 2 0 0 0 0 54 49 1 0 0 0 0 48 55 2 0 0 0 0 42 56 2 0 0 0 0 26 27 1 0 0 0 0 43 57 1 0 0 0 0 57 58 1 0 0 0 0 27 28 1 0 0 0 0 58 59 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 33 28 1 0 0 0 0 31 34 1 0 0 0 0 34 35 1 0 0 0 0 45 60 1 0 0 0 0 M END > CHEBI:76263 > proglumetacin > A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropyl-?-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. > 3 > 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate > proglumetacinum; proglumetacine; proglumetacina; proglumetacin > C46H58ClN5O8 > 844.43400 > 843.39739 > 0 > CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)CC1)NC(=O)c1ccccc1 > InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) > PTXGHCGBYMQQIG-UHFFFAOYSA-N > 57132-53-3 > 876871 > 57132-53-3 > D08427 > Proglumetacin > 1626095; 1778279; 2491526; 2653004; 2974384; 3663267; 3860726; 3887221; 3905222; 4074450; 6222270; 6222271; 6343924; 6381269; 6602308; 6602309; 6602310; 6728264; 6728268; 6856162; 6856163; 6856164; 6856165; 6856166; 6856167 $$$$