Mrv0541 03021516292D          

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M  END
> <ID>
CHEBI:3011

> <NAME>
benazepril

> <DEFINITION>
A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.

> <STAR>
3

> <SYNONYM>
Benazepril; 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-

> <IUPAC_NAME>
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid

> <INN>
benazeprilum; benazepril; benazepril; benazepril

> <FORMULA>
C24H28N2O5

> <MASS>
424.48950

> <MONOISOTOPIC_MASS>
424.19982

> <CHARGE>
0

> <SMILES>
CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O

> <INCHI>
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1

> <INCHIKEY>
XPCFTKFZXHTYIP-PMACEKPBSA-N

> <CAS_REGISTRY_NUMBER>
86541-75-5

> <REAXYS_REGISTRY_NUMBER>
4302258

> <CHEMIDPLUS>
86541-75-5

> <DRUGBANK_ACCESSION>
DB00542

> <KEGG_COMPOUND_ACCESSION>
C06843

> <KEGG_DRUG_ACCESSION>
D07499

> <LINCS_ACCESSION>
LSM-5609

> <METACYC_ACCESSION>
CPD-15329

> <WIKIPEDIA_ACCESSION>
Benazepril

> <PUBMED_CITATION>
25224804; 25738503; 25784709; 25912588

$$$$