Ketcher 04022415382D 1 1.00000 0.00000 0 35 39 0 0 0 999 V2000 12.1215 -6.7906 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.9875 -6.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9875 -5.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1214 -4.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2554 -6.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2554 -5.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3894 -4.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5234 -5.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5234 -6.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3894 -6.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1214 -3.7906 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.9875 -3.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8535 -3.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7195 -3.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7195 -2.2906 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 13.8535 -1.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9875 -2.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5856 -1.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8535 -6.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6574 -4.7906 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7913 -5.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6574 -6.7906 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7913 -6.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9253 -6.7906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0593 -6.2906 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1932 -6.7906 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0887 -7.7851 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1106 -7.9931 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6106 -7.1270 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2797 -6.3839 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9580 -7.7851 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.9362 -7.9930 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4362 -7.1270 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7671 -6.3838 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3429 -8.9065 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5 1 1 0 0 0 1 2 2 0 0 0 2 3 1 0 0 0 3 4 2 0 0 0 4 6 1 0 0 0 5 6 1 0 0 0 6 7 2 0 0 0 7 8 1 0 0 0 8 9 2 0 0 0 9 10 1 0 0 0 10 5 2 0 0 0 4 11 1 0 0 0 11 12 1 0 0 0 12 13 1 0 0 0 12 17 1 0 0 0 13 14 1 0 0 0 14 15 1 0 0 0 15 16 1 0 0 0 16 17 1 0 0 0 15 18 1 0 0 0 2 19 1 0 0 0 8 20 1 0 0 0 20 21 1 0 0 0 9 22 1 0 0 0 22 23 1 0 0 0 23 24 1 0 0 0 24 25 1 0 0 0 25 26 1 0 0 0 26 27 1 0 0 0 27 28 1 0 0 0 28 29 1 0 0 0 29 30 1 0 0 0 30 26 1 0 0 0 19 31 1 0 0 0 31 32 1 0 0 0 32 33 2 0 0 0 33 34 1 0 0 0 34 19 2 0 0 0 32 35 1 0 0 0 M END > CHEBI:229970 > CM-272 > A member of the class of aminoquinolines that is is quinoline substituted by 5-methylfuran-2-yl, (1-methylpiperidin-4-yl)amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a dual G9a/DNA methyltransferases inhibitor with antitumor activity. It inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP (IC50 = 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively). > 3 > CM272; CM 272; 6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine > 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine > C28H38N4O3 > 478.637 > 478.29439 > 0 > COC1=C(OCCCN2CCCC2)C=C2N=C(C=C(NC3CCN(C)CC3)C2=C1)C1=CC=C(C)O1 > InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30) > RLQLKZTYUYIWDB-UHFFFAOYSA-N > 1846570-31-7 > 28548080; 29953809; 30014490; 31270502; 32327527; 33222246; 33661013; 35324190; 35483199; 37356504; 38064417; 38285887 $$$$