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82 83 1 0 0 0 0 82 84 1 0 0 0 0 84 81 1 6 0 0 0 84 87 1 0 0 0 0 85 86 1 0 0 0 0 86 88 1 0 0 0 0 87 89 1 0 0 0 0 88 89 1 0 0 0 0 90 82 2 0 0 0 0 91 93 2 0 0 0 0 91 94 1 0 0 0 0 92 97 1 0 0 0 0 92 95 2 0 0 0 0 92 98 1 0 0 0 0 94 96 1 0 0 0 0 94 83 1 1 0 0 0 96 97 1 0 0 0 0 99 91 1 0 0 0 0 100101 1 0 0 0 0 100102 1 0 0 0 0 102 99 1 1 0 0 0 102104 1 0 0 0 0 103105 1 0 0 0 0 103106 1 0 0 0 0 104105 1 0 0 0 0 107100 2 0 0 0 0 108110 2 0 0 0 0 108111 1 0 0 0 0 109114 1 0 0 0 0 109112 1 0 0 0 0 109115 2 0 0 0 0 111113 1 0 0 0 0 113114 1 0 0 0 0 116108 1 0 0 0 0 114101 1 1 0 0 0 117119 2 0 0 0 0 117120 1 0 0 0 0 118123 1 0 0 0 0 118121 1 0 0 0 0 118124 2 0 0 0 0 120122 1 0 0 0 0 122123 1 0 0 0 0 125117 1 0 0 0 0 123112 1 6 0 0 0 126128 2 0 0 0 0 126129 1 0 0 0 0 127132 1 0 0 0 0 127130 1 0 0 0 0 127133 2 0 0 0 0 129131 1 0 0 0 0 131132 1 0 0 0 0 134126 1 0 0 0 0 132121 1 1 0 0 0 135136 1 0 0 0 0 135137 1 0 0 0 0 137130 1 6 0 0 0 137138 1 0 0 0 0 139135 2 0 0 0 0 140141 1 0 0 0 0 140142 1 0 0 0 0 141136 1 1 0 0 0 141143 1 0 0 0 0 143144 1 0 0 0 0 143145 1 0 0 0 0 146140 2 0 0 0 0 147149 2 0 0 0 0 147151 1 0 0 0 0 147153 1 0 0 0 0 148152 1 0 0 0 0 148150 1 0 0 0 0 151154 1 0 0 0 0 152155 1 0 0 0 0 152142 1 6 0 0 0 154156 1 0 0 0 0 155156 1 0 0 0 0 157148 2 0 0 0 0 158159 1 0 0 0 0 158160 1 0 0 0 0 159161 1 0 0 0 0 159150 1 1 0 0 0 162158 2 0 0 0 0 161163 1 0 0 0 0 163164 1 0 0 0 0 163165 1 0 0 0 0 166167 1 0 0 0 0 166168 1 0 0 0 0 167169 1 0 0 0 0 167160 1 6 0 0 0 170166 2 0 0 0 0 172171 1 0 0 0 0 173171 2 0 0 0 0 174172 2 0 0 0 0 175173 1 0 0 0 0 176174 1 0 0 0 0 176175 2 0 0 0 0 169171 1 0 0 0 0 177178 1 0 0 0 0 177179 1 0 0 0 0 178168 1 1 0 0 0 178180 1 0 0 0 0 180181 1 0 0 0 0 180182 1 0 0 0 0 181183 1 0 0 0 0 184177 2 0 0 0 0 185187 2 0 0 0 0 185188 1 0 0 0 0 186191 1 0 0 0 0 186189 1 0 0 0 0 186192 2 0 0 0 0 188190 1 0 0 0 0 190191 1 0 0 0 0 193185 1 0 0 0 0 191179 1 6 0 0 0 194195 2 0 0 0 0 194196 1 0 0 0 0 196197 1 0 0 0 0 196189 1 1 0 0 0 198194 1 0 0 0 0 200199 1 0 0 0 0 201199 2 0 0 0 0 203201 1 0 0 0 0 203202 1 0 0 0 0 197199 1 0 0 0 0 204200 1 0 0 0 0 202200 2 0 0 0 0 205204 2 0 0 0 0 206202 1 0 0 0 0 207205 1 0 0 0 0 207206 2 0 0 0 0 208209 1 0 0 0 0 208210 2 0 0 0 0 209211 1 0 0 0 0 209198 1 1 0 0 0 212208 1 0 0 0 0 211213 1 0 0 0 0 213214 1 0 0 0 0 213215 1 0 0 0 0 216217 1 0 0 0 0 216218 1 0 0 0 0 218212 1 1 0 0 0 218221 1 0 0 0 0 219220 1 0 0 0 0 220222 1 0 0 0 0 221223 1 0 0 0 0 222223 1 0 0 0 0 224216 2 0 0 0 0 225227 1 0 0 0 0 226227 1 0 0 0 0 226228 1 0 0 0 0 227217 1 6 0 0 0 229226 2 0 0 0 0 231230 2 0 0 0 0 232230 1 0 0 0 0 225230 1 0 0 0 0 233234 1 0 0 0 0 233235 1 0 0 0 0 236233 2 0 0 0 0 235228 1 0 0 0 0 237238 1 0 0 0 0 237239 1 0 0 0 0 240237 2 0 0 0 0 239234 1 0 0 0 0 241242 1 0 0 0 0 241243 2 0 0 0 0 244241 1 0 0 0 0 245238 1 0 0 0 0 242238 1 6 0 0 0 246245 1 0 0 0 0 247242 1 0 0 0 0 247246 1 0 0 0 0 248249 1 0 0 0 0 248250 1 0 0 0 0 249244 1 1 0 0 0 249251 1 0 0 0 0 251252 1 0 0 0 0 253248 2 0 0 0 0 254255 1 0 0 0 0 254256 1 0 0 0 0 255250 1 6 0 0 0 255257 1 0 0 0 0 257258 1 0 0 0 0 259254 2 0 0 0 0 260261 1 0 0 0 0 260262 1 0 0 0 0 263260 2 0 0 0 0 262256 1 1 0 0 0 264265 1 0 0 0 0 264266 1 0 0 0 0 266261 1 6 0 0 0 266267 1 0 0 0 0 268264 2 0 0 0 0 269270 2 0 0 0 0 269271 1 0 0 0 0 272269 1 0 0 0 0 274273 1 0 0 0 0 275273 1 0 0 0 0 271274 1 0 0 0 0 265275 1 0 0 0 0 271265 1 6 0 0 0 276277 1 0 0 0 0 276278 1 0 0 0 0 279276 2 0 0 0 0 281280 1 0 0 0 0 282280 1 0 0 0 0 278281 1 0 0 0 0 272282 1 0 0 0 0 278272 1 1 0 0 0 283284 1 0 0 0 0 283285 1 0 0 0 0 286283 2 0 0 0 0 288287 1 0 0 0 0 289287 1 0 0 0 0 285288 1 0 0 0 0 277289 1 0 0 0 0 285277 1 1 0 0 0 290291 1 0 0 0 0 290292 2 0 0 0 0 291284 1 6 0 0 0 291293 1 0 0 0 0 293294 1 0 0 0 0 295290 1 0 0 0 0 M END > CHEBI:64073 > exendin-4 > A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently induces cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide. > 3 > His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; Heloderma suspectum gila monster exendin-4; exendin-4; Exendin 4; Ex4 > L-histidylglycyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide > exenatidum; exenatide; exenatide; exenatida > C184H282N50O60S > 4186.57200 > 4184.02731 > 0 > CCC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)O)C(C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O > InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94?,95-,96-,97?,98?,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 > HTQBXNHDCUEHJF-URRANESESA-N > 141758-74-9 > 9040649 > 141758-74-9 > C15894 > D04121 > Exenatide > 12364473; 1313797; 14565957; 16353670; 17053883; 20149450; 20404826; 22310470; 22334721; 22338110; 22356440; 22363635; 22384126 $$$$