Marvin 12211116432D 38 40 0 0 0 0 999 V2000 8.1443 -16.9796 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8442 -17.3444 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.4593 -17.3825 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1443 -16.1546 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.6416 -14.9224 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.9353 -16.1142 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.6550 -15.7473 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2355 -14.9245 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9205 -14.5216 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2355 -15.7495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5504 -16.1524 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.8294 -15.7516 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8294 -14.9266 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5144 -14.5237 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4296 -13.3720 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7234 -13.7389 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7234 -14.5639 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4445 -14.9648 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1295 -14.5618 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1295 -13.7368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4296 -12.5470 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7086 -12.1462 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0383 -14.9669 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0383 -15.7919 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3761 -16.1481 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3895 -16.9730 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1105 -17.3738 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1239 -18.1987 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8450 -18.5996 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8562 -19.4245 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 13.1497 -19.8481 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1609 -20.6731 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5833 -19.8200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5974 -20.6498 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4556 -18.2096 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7393 -18.6189 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1682 -18.6253 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4556 -19.0346 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2 1 2 0 0 0 0 3 1 1 0 0 0 0 4 1 1 0 0 0 0 12 4 1 0 0 0 0 7 5 2 0 0 0 0 9 5 1 0 0 0 0 7 6 1 0 0 0 0 10 6 2 0 0 0 0 25 7 1 0 0 0 0 9 8 2 0 0 0 0 10 8 1 0 0 0 0 14 8 1 0 0 0 0 11 10 1 0 0 0 0 12 11 2 0 0 0 0 13 12 1 0 0 0 0 14 13 2 0 0 0 0 19 13 1 0 0 0 0 20 15 2 0 0 0 0 16 15 1 0 0 0 0 21 15 1 0 0 0 0 17 16 2 0 0 0 0 18 17 1 0 0 0 0 23 17 1 0 0 0 0 19 18 2 0 0 0 0 20 19 1 0 0 0 0 22 21 1 0 0 0 0 24 23 1 0 0 0 0 26 25 1 0 0 0 0 27 26 1 0 0 0 0 28 27 1 0 0 0 0 29 28 1 0 0 0 0 30 29 1 0 0 0 0 31 30 1 0 0 0 0 33 30 1 0 0 0 0 32 31 1 0 0 0 0 33 34 1 0 0 0 0 3 35 1 0 0 0 0 35 36 1 0 0 0 0 35 37 1 0 0 0 0 35 38 1 0 0 0 0 M END > CHEBI:63448 > PD173074 > A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor. > 3 > PD-173074; PD 173074 > 1-tert-butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea > C28H41N7O3 > 523.67020 > 523.32709 > 0 > CCN(CC)CCCCNc1ncc2cc(-c3cc(OC)cc(OC)c3)c(NC(=O)NC(C)(C)C)nc2n1 > InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) > DXCUKNQANPLTEJ-UHFFFAOYSA-N > 219580-11-7 > 10130688 > 219580-11-7 > LSM-1026 > 14598292; 14715624; 14960493; 16448042; 17356708; 19340397; 19903855; 19955487 $$$$