Marvin  09151008592D          

  7  6  0  0  0  0            999 V2000
    3.5684   -3.8168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5684   -2.9919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8538   -4.2293    0.0000 P   0  0  0  0  0  0  0  0  0  0  0  0
    4.2828   -4.2293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1394   -3.8168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8538   -5.0543    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6439   -3.4292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
M  END
> <ID>
CHEBI:127780

> <NAME>
phosphonoformic acid

> <DEFINITION>
Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

> <STAR>
3

> <SECONDARY_ID>
CHEBI:45085; CHEBI:8158

> <SYNONYM>
phosphonomethanoic acid; PHOSPHONOFORMIC ACID; Foscarnet; FOSCARNET; foscarnet; Foscarmet; carboxyphosphonic acid

> <IUPAC_NAME>
dihydroxyphosphanecarboxylic acid oxide

> <FORMULA>
CH3O5P

> <MASS>
126.00530

> <MONOISOTOPIC_MASS>
125.97181

> <CHARGE>
0

> <SMILES>
OC(=O)P(O)(O)=O

> <INCHI>
InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)

> <INCHIKEY>
ZJAOAACCNHFJAH-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
4428-95-9

> <REAXYS_REGISTRY_NUMBER>
1756501

> <CHEMIDPLUS>
4428-95-9

> <DRUGBANK_ACCESSION>
DB00529

> <KEGG_COMPOUND_ACCESSION>
C06456

> <KNAPSACK_ACCESSION>
C00000800

> <PDBECHEM_ACCESSION>
PPF

> <WIKIPEDIA_ACCESSION>
Foscarnet

> <PUBMED_CITATION>
11576919; 15182735; 16858125; 19213941; 19288498; 21056575; 21566148; 7518199

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