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M  END
> <ID>
CHEBI:9637

> <NAME>
torasemide

> <DEFINITION>
An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.

> <STAR>
3

> <SYNONYM>
Torsemide; N-[(propan-2-yl)carbamoyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; N-(isopropylcarbamoyl)-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; N-(((1-methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide; JDL-464; JDL 464; BM02015; BM02.015; BM-02015; BM-02.015; BM 02015; AC4464; AC-4464; AC 4464; 1-isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea

> <IUPAC_NAME>
4-(3-methylanilino)-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide

> <INN>
torasemidum; torasemide; torasemide; torasemida

> <BRAND_NAME>
Unat; Torem; Luprac; Demadex

> <FORMULA>
C16H20N4O3S

> <MASS>
348.420

> <MONOISOTOPIC_MASS>
348.12561

> <CHARGE>
0

> <SMILES>
C=1(C(NC=2C=C(C=CC2)C)=CC=NC1)S(NC(NC(C)C)=O)(=O)=O

> <INCHI>
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

> <INCHIKEY>
NGBFQHCMQULJNZ-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
56211-40-6

> <REAXYS_REGISTRY_NUMBER>
498515

> <CHEMIDPLUS>
56211-40-6

> <DRUGBANK_ACCESSION>
DB00214

> <KEGG_DRUG_ACCESSION>
D00382

> <LINCS_ACCESSION>
LSM-2662

> <WIKIPEDIA_ACCESSION>
Torasemide

> <PUBMED_CITATION>
21391491; 21906812; 22030290; 22364690; 22407343; 23013124; 23237447; 23792294; 23837587; 23877845; 24040049; 24243991; 24367917; 24432564; 24554915; 28891228; 29488197; 30649675; 30827731; 31124957; 31436024; 31699358; 31809955; 32098657; 32302808; 32411731

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