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M  END
> <ID>
CHEBI:145374

> <NAME>
enasidenib

> <DEFINITION>
A 1,3,5-triazine which is substituted by (2-hydroxy-2-methylpropyl)nitrilo, 6-(trifluoromethyl)pyridin-2-yl and [2-(trifluoromethyl)pyridin-4-yl]nitrilo groups at positions 2,4 and 6, respectively. It is an isocitrate dehydrogenase-2 (IDH2) inhibitor which has been approved for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML).

> <STAR>
3

> <SYNONYM>
CC-90007; AG-221; AG 221

> <IUPAC_NAME>
2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol

> <INN>
enasidenibum; enasidenib; enasidenib; enasidenib

> <BRAND_NAME>
Idhifa

> <FORMULA>
C19H17F6N7O

> <MASS>
473.383

> <MONOISOTOPIC_MASS>
473.13988

> <CHARGE>
0

> <SMILES>
C1(=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NCC(O)(C)C)NC=3C=CN=C(C3)C(F)(F)F

> <INCHI>
InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)

> <INCHIKEY>
DYLUUSLLRIQKOE-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
1446502-11-9

> <CHEMIDPLUS>
1446502-11-9

> <DRUGBANK_ACCESSION>
DB13874

> <KEGG_DRUG_ACCESSION>
D10901

> <PDBECHEM_ACCESSION>
69Q

> <WIKIPEDIA_ACCESSION>
Enasidenib

> <PUBMED_CITATION>
28193778; 28280273; 28461409; 28659444; 28818952; 28879540; 29320949; 29742078; 29770715; 29803908; 30013764; 30069631; 30360730; 30386625; 30663096; 30719396; 30858735; 30967620; 31118877; 31454277; 31564968; 31652462

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