Ketcher 06072113432D 1 1.00000 0.00000 0 35 39 0 0 0 999 V2000 10.3116 -7.2873 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1210 -6.7003 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6198 -8.2387 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9295 -7.2888 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6198 -8.2396 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9078 -7.0816 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5763 -7.8253 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2883 -8.9831 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2665 -8.7760 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3336 -7.0786 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6638 -7.8212 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9500 -8.9813 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9721 -8.7725 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1219 -5.7003 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.9884 -5.2011 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.5546 -7.6182 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 7.6858 -7.6125 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 7.0161 -8.3552 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 15.2232 -8.3619 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 16.2014 -8.1548 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0382 -8.1464 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3474 -6.6399 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 15.2983 -6.9497 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9432 -6.9428 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8946 -6.6345 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 16.5113 -7.2039 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8700 -8.8985 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.4896 -6.9969 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8484 -8.6914 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1581 -7.7406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3684 -8.8891 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7298 -7.1951 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3903 -8.6803 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7519 -6.9864 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0821 -7.7290 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 2 4 1 0 0 0 3 5 1 0 0 0 4 6 1 0 0 0 4 5 2 0 0 0 6 7 2 0 0 0 5 8 1 0 0 0 7 9 1 0 0 0 8 9 2 0 0 0 1 10 1 0 0 0 1 3 2 0 0 0 10 11 2 0 0 0 3 12 1 0 0 0 11 13 1 0 0 0 12 13 2 0 0 0 2 14 2 0 0 0 14 15 1 0 0 0 7 16 1 0 0 0 11 17 1 0 0 0 17 18 1 0 0 0 16 19 1 0 0 0 19 20 1 0 0 0 18 21 1 0 0 0 16 22 2 0 0 0 16 23 2 0 0 0 17 24 2 0 0 0 17 25 2 0 0 0 20 26 1 0 0 0 20 27 1 0 0 0 26 28 1 0 0 0 27 29 1 0 0 0 28 30 1 0 0 0 29 30 1 0 0 0 21 31 1 0 0 0 21 32 1 0 0 0 31 33 1 0 0 0 32 34 1 0 0 0 33 35 1 0 0 0 34 35 1 0 0 0 M END > CHEBI:176419 > FIN56 > A fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. > 3 > N(2),N(7)-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide; FIN-56; FIN 56 > N,N'-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide > C25H31N3O5S2 > 517.660 > 517.17051 > 0 > ON=C1C2=C(C=CC(=C2)S(=O)(=O)NC2CCCCC2)C2=C1C=C(C=C2)S(=O)(=O)NC1CCCCC1 > InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2 > JLCFMMIWBSZOIS-UHFFFAOYSA-N > 1083162-61-1 > 27159577; 27315536; 29610484; 30057310; 30686534; 30863316; 31441366; 33414455 $$$$