Mrv0541 02031411052D          

 31 33  0  0  0  0            999 V2000
    5.7712   -6.1808    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0567   -6.5933    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3422   -6.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6277   -1.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9132   -1.2308    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3422   -1.2308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7711   -5.3558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9132   -2.8808    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6277   -6.5933    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6277   -2.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3422   -5.3558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3422   -0.4058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0566   -1.6433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4856   -4.9433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0567   -4.9433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1988   -1.6433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1988   -2.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4856   -4.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0567   -4.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7711   -3.7058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9133   -6.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0567   -2.4683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7711   -2.8808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4843   -2.8808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9133   -5.3558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1988   -6.5933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1988   -4.9433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4843   -6.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4843   -5.3558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5962   -6.1808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1837   -6.8953    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  7  1  1  0  0  0  0
  3  2  1  0  0  0  0
  9  3  1  0  0  0  0
 11  3  2  0  0  0  0
  6  4  1  0  0  0  0
  5  4  1  0  0  0  0
 10  4  2  0  0  0  0
 16  5  2  0  0  0  0
 13  6  1  0  0  0  0
 12  6  2  0  0  0  0
 14  7  2  0  0  0  0
 15  7  1  0  0  0  0
 10  8  1  0  0  0  0
 17  8  2  0  0  0  0
 21  9  1  0  0  0  0
 22 13  1  0  0  0  0
 18 14  1  0  0  0  0
 19 15  2  0  0  0  0
 17 16  1  0  0  0  0
 24 17  1  0  0  0  0
 20 18  2  0  0  0  0
 20 19  1  0  0  0  0
 23 20  1  0  0  0  0
 25 21  1  0  0  0  0
 26 21  1  0  0  0  0
 23 22  1  0  0  0  0
 27 25  1  0  0  0  0
 28 26  1  0  0  0  0
 29 27  1  0  0  0  0
 29 28  1  0  0  0  0
 30  1  2  0  0  0  0
 31  1  2  0  0  0  0
M  END
> <ID>
CHEBI:5384

> <NAME>
glipizide

> <DEFINITION>
An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.

> <STAR>
3

> <SYNONYM>
N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylurea; K 4024; CP-28,720; CP 28720; CP 28,720; 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea

> <IUPAC_NAME>
N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide

> <INN>
glipizidum; glipizide; glipizide; glipizida

> <BRAND_NAME>
Sucrazide; Ozidia; Napizide; Minodiab; Minidiab; Minidab; Mindiab; Melizide; Glydiazinamide; Glyde; Glupizide; Glupitel; Glucozide; Glucotrol; Glucolip; Gluco-Rite; Glipid; Glidiab; Glican; Glibetin; Glibenese; Dipazide; Digrin; Aldiab

> <FORMULA>
C21H27N5O4S

> <MASS>
445.53500

> <MONOISOTOPIC_MASS>
445.17838

> <CHARGE>
0

> <SMILES>
Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1

> <INCHI>
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

> <INCHIKEY>
ZJJXGWJIGJFDTL-UHFFFAOYSA-N

> <CAS_REGISTRY_NUMBER>
29094-61-9

> <REAXYS_REGISTRY_NUMBER>
903495

> <CHEMIDPLUS>
29094-61-9

> <DRUGBANK_ACCESSION>
DB01067

> <KEGG_DRUG_ACCESSION>
D00335

> <LINCS_ACCESSION>
LSM-2251

> <WIKIPEDIA_ACCESSION>
Glipizide

> <PUBMED_CITATION>
11147395; 20797618; 23230096; 24418334; 24444583; 2665487; 3143256; 389600; 3923454; 7660535

$$$$