CHEBI:71019 - omacetaxine mepesuccinate

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ChEBI Name omacetaxine mepesuccinate
ChEBI ID CHEBI:71019
Definition A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C29H39NO9
Net Charge 0
Average Mass 545.62130
Monoisotopic Mass 545.262
InChI InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKey HYFHYPWGAURHIV-JFIAXGOJSA-N
SMILES [H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
Roles Classification
Biological Role(s): protein synthesis inhibitor
A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing omacetaxine mepesuccinate (CHEBI:71019) has functional parent cephalotaxine (CHEBI:3540)
omacetaxine mepesuccinate (CHEBI:71019) has role antineoplastic agent (CHEBI:35610)
omacetaxine mepesuccinate (CHEBI:71019) has role apoptosis inducer (CHEBI:68495)
omacetaxine mepesuccinate (CHEBI:71019) has role protein synthesis inhibitor (CHEBI:48001)
omacetaxine mepesuccinate (CHEBI:71019) is a alkaloid ester (CHEBI:38481)
omacetaxine mepesuccinate (CHEBI:71019) is a enol ether (CHEBI:47985)
omacetaxine mepesuccinate (CHEBI:71019) is a organic heteropentacyclic compound (CHEBI:38164)
omacetaxine mepesuccinate (CHEBI:71019) is a tertiary alcohol (CHEBI:26878)
INNs Sources
mépésuccinate d'omacétaxine WHO MedNet
mepesuccinato de omacetaxina WHO MedNet
omacetaxine mepesuccinate WHO MedNet
omacetaxini mepesuccinas WHO MedNet
Synonyms Sources
(−)-homoharringtonine ChEBI
(2'R,3S,4S,5R)-(−)-homoharringtonine ChEBI
CGX-635 ChemIDplus
Homoharringtonine KEGG DRUG
Brand Name Source
Synribo ChemIDplus
Database Links Databases
D08956 KEGG DRUG
HMT PDBeChem
LSM-3716 LINCS
Omacetaxine_mepesuccinate Wikipedia
US2010240887 Patent
WO2007089878 Patent
View more database links
Registry Numbers Types Sources
26833-87-4 CAS Registry Number ChemIDplus
26833-87-4 CAS Registry Number KEGG DRUG
5687925 Beilstein Registry Number ChemIDplus
5687925 Reaxys Registry Number Reaxys
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Last Modified
25 февраля 2016