User Survey :
Help improve ChEBI - please click here to take part in our quick User Survey.
CHEBI:6078 - ivermectin
A mixture consisting of ≥ 90% 22,23-dihydroavermectin B1a (R = Me) and ≤ 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
This entity has been manually annotated by the ChEBI Team.
A positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).