artemether (CHEBI:195280)

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ChEBI Name	artemether

ChEBI ID	CHEBI:195280

Definition	An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C16H26O5

Net Charge

Average Mass

298.37460

Monoisotopic Mass

298.17802

InChI

InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

InChIKey

SXYIRMFQILZOAM-HVNFFKDJSA-N

SMILES

[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3

Roles Classification
Chemical Role(s):	oxidising agent A substance that removes electrons from another reactant in a redox reaction. (via peroxides )

Biological Role(s):	antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

Application(s):	antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

ChEBI Ontology
Outgoing	artemether (CHEBI:195280) has role antimalarial (CHEBI:38068) artemether (CHEBI:195280) is a artemisinin derivative (CHEBI:63920) artemether (CHEBI:195280) is a cyclic acetal (CHEBI:59770) artemether (CHEBI:195280) is a organic peroxide (CHEBI:25702) artemether (CHEBI:195280) is a semisynthetic derivative (CHEBI:72588) artemether (CHEBI:195280) is a sesquiterpenoid (CHEBI:26658)

IUPAC Name

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine

Synonyms	Sources
(1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane	ChEBI
10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane	ChEMBL
artemisininelactol methyl ether	ChemIDplus
β-artemether	ChemIDplus
β-dihydroartemisinin methyl ether	ChemIDplus
dihydroartemisinin methyl ether	ChemIDplus
methyl-dihydroartemisinine	ChemIDplus

Last Modified

22 febrero 2017