CHEBI:50169 - brexanolone

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name brexanolone
ChEBI ID CHEBI:50169
Definition A 3-hydroxy-5α-pregnan-20-one in which the hydroxy group at position 3 has α-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:34347, CHEBI:32924
Supplier Information
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Roles Classification
Biological Role(s): human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
intravenous anaesthetic

sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Related Structures
brexanolone is a Structural Derivative of
5alpha-pregnane
Mass : 288.51054
Formula : C21H36
20656 		pregnane
Mass : 288.51054
Formula : C21H36
8386
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