CHEBI:48045 - salinosporamide A

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ChEBI Name salinosporamide A
ChEBI ID CHEBI:48045
Definition A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): marine metabolite
Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
(via salinosporamide )
bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
(via salinosporamide )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
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