CHEBI:31653 - glafenine

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name glafenine
ChEBI ID CHEBI:31653
Definition A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:344737
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
inhibitor
A substance that diminishes the rate of a chemical reaction.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Related Structures
glafenine is a Structural Derivative of
glycerol
Mass : 92.09382
Formula : C3H8O3
17754 		anthranilic acid
Mass : 137.13600
Formula : C7H7NO2
30754 		ammonia
Mass : 17.03056
Formula : H3N
16134
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