CHEBI:68584 - ezogabine

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ChEBI Name ezogabine ChEBI ID CHEBI:68584 Definition A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C16H18FN3O2 Net Charge 0 Average Mass 303.33140 Monoisotopic Mass 303.13830 InChI InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) InChIKey PCOBBVZJEWWZFR-UHFFFAOYSA-N SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N Roles Classification Chemical Role(s): Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound ) Biological Role(s): potassium channel modulator Application(s): anticonvulsant A drug used to prevent seizures or reduce their severity. View more via ChEBI Ontology ChEBI Ontology Outgoing ezogabine (CHEBI:68584) has functional parent benzene-1,2,4-triamine (CHEBI:29148) ezogabine (CHEBI:68584) has role anticonvulsant (CHEBI:35623) ezogabine (CHEBI:68584) has role potassium channel modulator (CHEBI:50510) ezogabine (CHEBI:68584) is a carbamate ester (CHEBI:23003) ezogabine (CHEBI:68584) is a organofluorine compound (CHEBI:37143) ezogabine (CHEBI:68584) is a secondary amino compound (CHEBI:50995) ezogabine (CHEBI:68584) is a substituted aniline (CHEBI:48975) INN Source retigabine KEGG DRUG Synonyms Sources D-23129 ChemIDplus D-23129 KEGG COMPOUND Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate ChemIDplus ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate ChEBI N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester KEGG COMPOUND N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester ChemIDplus Brand Name Source Potiga KEGG DRUG Manual Xrefs Databases 4181 DrugCentral C13826 KEGG COMPOUND D09569 KEGG DRUG Ezogabine Wikipedia US2002015730 Patent US2002111379 Patent US2002183395 Patent US2012053238 Patent US5384330 Patent US6348486 Patent WO2007090409 Patent WO2011012659 Patent View more database links Registry Numbers Types Sources 150812-12-7 CAS Registry Number KEGG COMPOUND 150812-12-7 CAS Registry Number ChemIDplus 8072099 Reaxys Registry Number Reaxys Citation Type Source 22991134 PubMed citation Europe PMC Last Modified 22 February 2017