# # This file is automatically generated with # the System Biology Format Converter (http://sbfc.sourceforge.net/) # from an SBML file. # # # Model name = Proctor2011_ProteinHomeostasis_NormalCondition # # is http://identifiers.org/biomodels.db/MODEL1005280000 # is http://identifiers.org/biomodels.db/BIOMD0000000344 # isDescribedBy http://identifiers.org/pubmed/21779370 # isDerivedFrom http://identifiers.org/biomodels.db/BIOMD0000000091 # # some function definitions that are allowed in SBML but not valid in xpp ceil(x)=flr(1+x) @delay=50 # Compartment: id = cytosol, name = cytosol, constant par cytosol=1.0 # Compartment: id = nucleus, name = nucleus, constant par nucleus=1.0 # Parameter: id = ksynNatP, name = ksynNatP, constant par ksynNatP=0.042 # Parameter: id = kmisfold, name = kmisfold, constant par kmisfold=2.0E-6 # Parameter: id = kbinMisPProt, name = kbinMisPProt, constant par kbinMisPP=1.0E-7 # Parameter: id = kdegMisP, name = kdegMisP, constant par kdegMisP=0.01 # Parameter: id = kagg, name = kagg, constant par kagg=1.0E-8 # Parameter: id = kseqagg, name = kseqagg, constant par kseqagg=7.0E-7 # Parameter: id = kbinAggPProt, name = kbinAggPProt, constant par kbinAggPP=1.0E-5 # Parameter: id = kbinHspMisp, name = kbinHspMisp, constant par kbinHspMi=8.0E-6 # Parameter: id = krelHspMisp, name = krelHspMisp, constant par krelHspMi=8.0E-5 # Parameter: id = krefold, name = krefold, constant par krefold=5.5E-4 # Parameter: id = kbinHsf1Hsp90, name = kbinHsf1Hsp90 # Warning parameter kbinHsf1Hsp90 is not constant, it should be controled by a Rule and/or events par kbinHsf1H=0.02 # Parameter: id = krelHsf1Hsp90, name = krelHsf1Hsp90, constant par krelHsf1H=0.5 # Parameter: id = kdimerHsf1, name = kdimerHsf1, constant par kdimerHsf=8.0E-5 # Parameter: id = ktrimerHsf1, name = ktrimerHsf1, constant par ktrimerHs=0.01 # Parameter: id = kdetrimerHsf1, name = kdetrimerHsf1, constant par kdetrimer=0.5 # Parameter: id = kdedimerHsf1, name = kdedimerHsf1, constant par kdedimerH=0.5 # Parameter: id = kbinHSEHsf1, name = kbinHSEHsf1, constant par kbinHSEHs=0.05 # Parameter: id = krelHSEHsf1, name = krelHSEHsf1, constant par krelHSEHs=0.08 # Parameter: id = kupregHsp, name = kupregHsp, constant par kupregHsp=0.2 # Parameter: id = kbasalsynHsp70, name = kbasalsynHsp70, constant par kbasalsyn=0.008 # Parameter: id = kbasalsynHsp90, name = kbasalsynHsp90, constant par kbasals_1=0.008 # Parameter: id = kbinHsp70Prot, name = kbinHsp70Prot, constant par kbinHsp70=1.2E-8 # Parameter: id = kbinHsp90Prot, name = kbinHsp90Prot, constant par kbinHsp90=1.0E-8 # Parameter: id = kdegHsp70, name = kdegHsp70, constant par kdegHsp70=0.01 # Parameter: id = kdegHsp90, name = kdegHsp90, constant par kdegHsp90=0.01 # Parameter: id = kgenROS, name = kgenROS # Warning parameter kgenROS is not constant, it should be controled by a Rule and/or events par kgenROS=0.01 # Parameter: id = kremROS, name = kremROS, constant par kremROS=0.001 # Parameter: id = kbinHsp70client, name = kbinHsp70client, constant par kbinHsp_1=2.0E-4 # Parameter: id = krelHsp70client, name = krelHsp70client, constant par krelHsp70=5.0 # Parameter: id = kbinHsp90client, name = kbinHsp90client, constant par kbinHsp_2=2.0E-4 # Parameter: id = krelHsp90client, name = krelHsp90client # Warning parameter krelHsp90client is not constant, it should be controled by a Rule and/or events par krelHsp90=5.0 # Parameter: id = kphosJnk, name = kphosJnk, constant par kphosJnk=0.02 # Parameter: id = kdephosJnkMkp1, name = kdephosJnkMkp1, constant par kdephosJn=0.05 # Parameter: id = kbinHsp70Ppx, name = kbinHsp70Ppx, constant par kbinHsp_3=0.2 # Parameter: id = krelHsp70Ppx, name = krelHsp70Ppx, constant par krelHsp_1=5.0 # Parameter: id = kphosHsf1, name = kphosHsf1, constant par kphosHsf1=0.03 # Parameter: id = kdephosHsf1, name = kdephosHsf1, constant par kdephosHs=0.01 # Parameter: id = kbinHSEPhosTriH, name = kbinHSEPhosTriH, constant par kbinHSEPh=0.1 # Parameter: id = krelHSEPhosTriH, name = krelHSEPhosTriH, constant par krelHSEPh=0.08 # Parameter: id = kphosp38, name = kphosp38, constant par kphosp38=0.02 # Parameter: id = kdephosp38Mkp1, name = kdephosp38Mkp1, constant par kdephosp3=0.05 # Parameter: id = kgenROSAggP, name = kgenROSAggP, constant par kgenROSAg=1.0E-6 # Parameter: id = ksynAkt, name = ksynAkt, constant par ksynAkt=0.0015 # Parameter: id = kbinAktHsp90, name = kbinAktHsp90, constant par kbinAktHs=3.7E-4 # Parameter: id = krelAktHsp90, name = krelAktHsp90 # Warning parameter krelAktHsp90 is not constant, it should be controled by a Rule and/or events par krelAktHs=7.0 # Parameter: id = kbinAktProt, name = kbinAktProt, constant par kbinAktPr=6.0E-8 # Parameter: id = krelAktProt, name = krelAktProt, constant par krelAktPr=1.0E-8 # Parameter: id = kdegAkt, name = kdegAkt, constant par kdegAkt=0.01 # Parameter: id = kbinCHIP, name = kbinCHIP, constant par kbinCHIP=2.0E-7 # Parameter: id = krelCHIP, name = krelCHIP, constant par krelCHIP=1.0E-8 # Parameter: id = ksynMkp1, name = ksynMkp1, constant par ksynMkp1=1.0E-5 # Parameter: id = kbinMkp1Prot, name = kbinMkp1Prot, constant par kbinMkp1P=9.6E-9 # Parameter: id = kdegMkp1, name = kdegMkp1, constant par kdegMkp1=0.01 # Parameter: id = kphosMkp1, name = kphosMkp1, constant par kphosMkp1=0.02 # Parameter: id = kdephosMkp1, name = kdephosMkp1, constant par kdephosMk=0.001 # Parameter: id = kgenROSp38, name = kgenROSp38, constant par kgenROSp3=1.0E-4 # Parameter: id = kdamHsp, name = kdamHsp, constant par kdamHsp=1.0E-8 # Parameter: id = kp38death, name = kp38death, constant par kp38death=1.5E-7 # Parameter: id = kJnkdeath, name = kJnkdeath, constant par kJnkdeath=1.5E-7 # Parameter: id = kPIdeath, name = kPIdeath, constant par kPIdeath=2.0E-8 # Parameter: id = kp38act, name = kp38act # Warning parameter kp38act is not constant, it should be controled by a Rule and/or events par kp38act=1.0 # Parameter: id = kalive, name = kalive par kalive=1.0 # Parameter: id = tot_Hsp90, name = tot_Hsp90, defined by a Rule # Parameter: id = tot_Hsp70, name = tot_Hsp70, defined by a Rule # Parameter: id = tot_MisP, name = tot_MisP, defined by a Rule # assignmentRule: variable = tot_Hsp90 tot_Hsp90=Hsp90+Hsp90_dam+Hsp90_Pro+Hsp90_Hsp+Akt_Hsp90+Akt_CHIP_+Hsf1_Hsp9+Hsp90_Mis aux tot_Hsp90=tot_Hsp90 # assignmentRule: variable = tot_Hsp70 tot_Hsp70=Hsp70+Hsp70_dam+Hsp70_Pro+Hsp70_Hsp+Hsp70_Mis+Hsp70_Ppx aux tot_Hsp70=tot_Hsp70 # assignmentRule: variable = tot_MisP tot_MisP=MisP+Hsp70_Mis+Hsp90_Mis aux tot_MisP=tot_MisP # Reaction: id = ProteinSynthesis ProteinSy=ksynNatP*Source*kalive # Reaction: id = Misfolding Misfoldin=kmisfold*NatP*ROS*kalive # Reaction: id = Hsp90MisPBinding Hsp90MisP=kbinHspMi*MisP*Hsp90*kalive # Reaction: id = Hsp90unsuccessulRefolding Hsp90unsu=krelHspMi*Hsp90_Mis*kalive # Reaction: id = Hsp90refolding Hsp90refo=krefold*Hsp90_Mis*kalive*ATP/(5000+ATP) # Reaction: id = Hsp70MisPBinding Hsp70MisP=kbinHspMi*MisP*Hsp70*kalive # Reaction: id = Hsp70unsuccessulRefolding Hsp70unsu=krelHspMi*Hsp70_Mis*kalive # Reaction: id = Hsp70refolding Hsp70refo=krefold*Hsp70_Mis*kalive*ATP/(5000+ATP) # Reaction: id = Hsp70ClientBinding Hsp70Cl_1=kbinHsp_1*Hsp70*Hsp70Clie*kalive # Reaction: id = Hsp70ClientRelease Hsp70Cl_2=krelHsp70*Hsp70_Hsp*kalive # Reaction: id = Hsp90ClientBinding Hsp90Cl_1=kbinHsp_2*Hsp90*Hsp90Clie*kalive # Reaction: id = Hsp90ClientRelease Hsp90Cl_2=krelHsp90*Hsp90_Hsp*kalive # Reaction: id = Hsp90HSF1Binding Hsp90HSF1=kbinHsf1H*Hsp90*Hsf1*kalive # Reaction: id = Hsp90HSF1Release Hsp90HS_1=krelHsf1H*Hsf1_Hsp9*kalive # Reaction: id = dimerisation dimerisat=(Hsf1-1)*kdimerHsf*kalive*Hsf1/2 # Reaction: id = trimerisation trimerisa=ktrimerHs*Hsf1*Hsf1_Hs_2*kalive # Reaction: id = deTrimerisation deTrimeri=kdetrimer*Hsf1_Hsf1*kalive # Reaction: id = deDimerisation deDimeris=kdedimerH*Hsf1_Hs_2*kalive # Reaction: id = HSE70TriHBinding HSE70TriH=kbinHSEHs*HSEHsp70*Hsf1_Hsf1*kalive # Reaction: id = HSE70TriHRelease HSE70Tr_1=krelHSEHs*HSEHsp70_*kalive # Reaction: id = HSE90TriHBinding HSE90TriH=kbinHSEHs*HSEHsp90*Hsf1_Hsf1*kalive # Reaction: id = HSE90TriHRelease HSE90Tr_1=krelHSEHs*HSEHsp90_*kalive # Reaction: id = Hsf1_Hsf1_Hsf1Phosphorylation Hsf1_Hs_3=kphosHsf1*Hsf1_Hsf1*Pkc*kalive # Reaction: id = Hsf1_Hsf1_Hsf1DePhosphorylation Hsf1_Hs_4=kdephosHs*Hsf1_Hs_1*Hsp70_Ppx*kalive # Reaction: id = HSE70PhosTriHBinding HSE70Phos=kbinHSEPh*HSEHsp70*Hsf1_Hs_1*kalive # Reaction: id = HSE70PhosTriHRelease HSE70Ph_1=krelHSEPh*HSEHsp7_1*kalive # Reaction: id = HSE90PhosTriHBinding HSE90Phos=kbinHSEPh*HSEHsp90*Hsf1_Hs_1*kalive # Reaction: id = HSE90PhosTriHRelease HSE90Ph_1=krelHSEPh*HSEHsp9_1*kalive # Reaction: id = Hsp90BasalSynthesis Hsp90Basa=kbasals_1*kalive # Reaction: id = Hsp90Upregulation Hsp90Upre=kupregHsp*HSEHsp9_1*kalive # Reaction: id = Hsp90ProteasomeBinding Hsp90Prot=kbinHsp90*Hsp90*Proteasom*kalive # Reaction: id = Hsp90Degradation Hsp90Degr=kdegHsp90*Hsp90_Pro*kalive*ATP/(5000+ATP) # Reaction: id = Hsp70BasalSynthesis Hsp70Basa=kbasalsyn*kalive # Reaction: id = Hsp70Upregulation Hsp70Upre=kupregHsp*HSEHsp7_1*kalive # Reaction: id = Hsp70ProteasomeBinding Hsp70Prot=kbinHsp70*Hsp70*Proteasom*kalive # Reaction: id = Hsp70Degradation Hsp70Degr=kdegHsp70*Hsp70_Pro*kalive*ATP/(5000+ATP) # Reaction: id = MisPProteasomeBinding1 MisPProte=kbinMisPP*Hsp70_Mis*Proteasom*kalive # Reaction: id = MisPProteasomeBinding2 MisPPro_1=kbinMisPP*Hsp90_Mis*Proteasom*kalive # Reaction: id = MisPDegradation MisPDegra=kdegMisP*MisP_Prot*kalive*ATP/(5000+ATP) # Reaction: id = radicalFormation, name = radicalFormation radicalFo=kgenROS*Source*kalive # Reaction: id = radicalScavenging, name = radicalScavenging radicalSc=kremROS*ROS*kalive # Reaction: id = Hsp70_PpxBinding Hsp70_P_1=kbinHsp_3*Hsp70*Ppx*kalive # Reaction: id = Hsp70_PPXRelease Hsp70_P_2=krelHsp_1*Hsp70_Ppx*kalive # Reaction: id = JnkPhosphorylation JnkPhosph=kphosJnk*Jnk*ROS*kalive # Reaction: id = JNKDephosphorylatioByMkp1 JNKDephos=kdephosJn*Jnk_P*Mkp1_P*kalive # Reaction: id = p38Phosphorylation p38Phosph=kphosp38*ROS*p38*kalive # Reaction: id = p38DePhosphorylationByMkp1 p38DePhos=kdephosp3*p38_P*Mkp1_P*kalive # Reaction: id = Aggregation1 Aggregati=kagg*MisP*(MisP-1)*0.5*kalive # Reaction: id = SequesteringOfAggregate Sequester=kagg*MisP*AggP*kalive # Reaction: id = InclusionGrowth Inclusion=kseqagg*SeqAggP*MisP*kalive # Reaction: id = ProteasomeInhibtion Proteas_1=kbinAggPP*AggP*Proteasom*kalive # Reaction: id = ROSgenerationSmallAggP ROSgenera=kgenROSAg*AggP*kalive # Reaction: id = ROSgenerationAggPProteasome ROSgene_1=kgenROSAg*AggP_Prot*kalive # Reaction: id = AktSynthesis AktSynthe=ksynAkt*Source*kalive # Reaction: id = Hsp90AktBinding Hsp90AktB=kbinAktHs*Hsp90*Akt*kalive # Reaction: id = Hsp90AktRelease Hsp90AktR=krelAktHs*Akt_Hsp90*kalive # Reaction: id = CHIPbinding CHIPbindi=kbinCHIP*CHIP*Akt_Hsp90*kalive # Reaction: id = CHIPrelease CHIPrelea=krelCHIP*Akt_CHIP_*kalive # Reaction: id = AktProteasomeBinding AktProtea=kbinAktPr*Akt_CHIP_*Proteasom*kalive # Reaction: id = AktProteasomeRelease AktProt_1=krelAktPr*Akt_Prote*kalive # Reaction: id = AktDegradation AktDegrad=kdegAkt*Akt_Prote*kalive*ATP/(5000+ATP) # Reaction: id = Mkp1Synthesis Mkp1Synth=ksynMkp1*Source*kalive # Reaction: id = Mkp1ProteasomeBinding Mkp1Prote=kbinMkp1P*Mkp1*Proteasom*kalive # Reaction: id = Mkp1Degradation Mkp1Degra=kdegMkp1*Mkp1_Prot*kalive*ATP/(5000+ATP) # Reaction: id = Mkp1Phosphorylation Mkp1Phosp=kphosMkp1*Mkp1*Hsp70*kalive # Reaction: id = Mkp1Dephosphorylation Mkp1Depho=kdephosMk*Mkp1_P*ROS*kalive # Reaction: id = p38ROSproduction p38ROSpro=kgenROSp3*p38_P*kalive*kp38act # Reaction: id = Hsp70Damage Hsp70Dama=kdamHsp*Hsp70*ROS*kalive # Reaction: id = Hsp90Damage Hsp90Dama=kdamHsp*Hsp90*ROS*kalive # Reaction: id = Hsp70DamProteasomeBinding Hsp70DamP=kbinHsp70*Hsp70_dam*Proteasom*kalive # Reaction: id = Hsp90DamProteasomeBinding Hsp90DamP=kbinHsp90*Hsp90_dam*Proteasom*kalive # Reaction: id = Hsp70DamAggregation1 Hsp70Da_1=kagg*Hsp70_dam*(Hsp70_dam-1)*0.5*kalive # Reaction: id = Hsp70DamInclusionFormation Hsp70DamI=kagg*Hsp70_dam*AggP*kalive # Reaction: id = Hsp90DamAggregation Hsp90Da_1=kagg*Hsp90_dam*(Hsp90_dam-1)*0.5*kalive # Reaction: id = Hsp90DamInclusionFormation Hsp90DamI=kagg*Hsp90_dam*AggP*kalive # Reaction: id = Hsp70DamSequestering Hsp70DamS=kseqagg*Hsp70_dam*SeqAggP*kalive # Reaction: id = Hsp90DamSequestering Hsp90DamS=kseqagg*Hsp90_dam*SeqAggP*kalive # Reaction: id = p38CellDeath p38CellDe=kp38death*p38_P*kalive*kp38act # Reaction: id = JnkCellDeath JnkCellDe=kJnkdeath*Jnk_P*kalive # Reaction: id = PICellDeath PICellDea=kPIdeath*AggP_Prot*kalive # Species: id = NatP, name = NatP, affected by kineticLaw init NatP=17600.0 dNatP/dt=( 1.0 * ProteinSy) + (-1.0 * Misfoldin) + ( 1.0 * Hsp90refo) + ( 1.0 * Hsp70refo) # Species: id = MisP, name = MisP, affected by kineticLaw init MisP=0.0 dMisP/dt=( 1.0 * Misfoldin) + (-1.0 * Hsp90MisP) + ( 1.0 * Hsp90unsu) + (-1.0 * Hsp70MisP) + ( 1.0 * Hsp70unsu) + (-2.0 * Aggregati) + (-1.0 * Sequester) + (-1.0 * Inclusion) # Species: id = Hsp70, name = Hsp70, affected by kineticLaw init Hsp70=1400.0 dHsp70/dt=(-1.0 * Hsp70MisP) + ( 1.0 * Hsp70unsu) + ( 1.0 * Hsp70refo) + (-1.0 * Hsp70Cl_1) + ( 1.0 * Hsp70Cl_2) + ( 1.0 * Hsp70Basa) + ( 1.0 * Hsp70Upre) + (-1.0 * Hsp70Prot) + ( 1.0 * MisPProte) + (-1.0 * Hsp70_P_1) + ( 1.0 * Hsp70_P_2) + (-1.0 * Mkp1Phosp) + ( 1.0 * Mkp1Phosp) + (-1.0 * Hsp70Dama) # Species: id = Hsp90, name = Hsp90, affected by kineticLaw init Hsp90=1850.0 dHsp90/dt=(-1.0 * Hsp90MisP) + ( 1.0 * Hsp90unsu) + ( 1.0 * Hsp90refo) + (-1.0 * Hsp90Cl_1) + ( 1.0 * Hsp90Cl_2) + (-1.0 * Hsp90HSF1) + ( 1.0 * Hsp90HS_1) + ( 1.0 * Hsp90Basa) + ( 1.0 * Hsp90Upre) + (-1.0 * Hsp90Prot) + ( 1.0 * MisPPro_1) + (-1.0 * Hsp90AktB) + ( 1.0 * Hsp90AktR) + ( 1.0 * AktProtea) + (-1.0 * Hsp90Dama) # Species: id = Hsp70_dam, name = Hsp70_dam, affected by kineticLaw init Hsp70_dam=0.0 dHsp70_dam/dt=( 1.0 * Hsp70Dama) + (-1.0 * Hsp70DamP) + (-2.0 * Hsp70Da_1) + (-1.0 * Hsp70DamI) + (-1.0 * Hsp70DamS) # Species: id = Hsp90_dam, name = Hsp90_dam, affected by kineticLaw init Hsp90_dam=0.0 dHsp90_dam/dt=( 1.0 * Hsp90Dama) + (-1.0 * Hsp90DamP) + (-2.0 * Hsp90Da_1) + (-1.0 * Hsp90DamI) + (-1.0 * Hsp90DamS) # Species: id = Hsp90_Proteasome, name = Hsp90_Proteasome, affected by kineticLaw par Hsp90_Pro=0.0 aux Hsp90_Pro=Hsp90_Pro dHsp90_Pro/dt=( 1.0 * Hsp90Prot) + (-1.0 * Hsp90Degr) + ( 1.0 * Hsp90DamP) # Species: id = Hsp70_Proteasome, name = Hsp70_Proteasome, affected by kineticLaw par Hsp70_Pro=0.0 aux Hsp70_Pro=Hsp70_Pro dHsp70_Pro/dt=( 1.0 * Hsp70Prot) + (-1.0 * Hsp70Degr) + ( 1.0 * Hsp70DamP) # Species: id = Hsp70Client, name = Hsp70Client, affected by kineticLaw par Hsp70Clie=490.0 aux Hsp70Clie=Hsp70Clie dHsp70Clie/dt=(-1.0 * Hsp70Cl_1) + ( 1.0 * Hsp70Cl_2) # Species: id = Hsp90Client, name = Hsp90Client, affected by kineticLaw par Hsp90Clie=590.0 aux Hsp90Clie=Hsp90Clie dHsp90Clie/dt=(-1.0 * Hsp90Cl_1) + ( 1.0 * Hsp90Cl_2) # Species: id = Hsp70_Hsp70Client, name = Hsp70_Hsp70Client, affected by kineticLaw par Hsp70_Hsp=10.0 aux Hsp70_Hsp=Hsp70_Hsp dHsp70_Hsp/dt=( 1.0 * Hsp70Cl_1) + (-1.0 * Hsp70Cl_2) # Species: id = Hsp90_Hsp90Client, name = Hsp90_Hsp90Client, affected by kineticLaw par Hsp90_Hsp=10.0 aux Hsp90_Hsp=Hsp90_Hsp dHsp90_Hsp/dt=( 1.0 * Hsp90Cl_1) + (-1.0 * Hsp90Cl_2) # Species: id = Akt, name = Akt, affected by kineticLaw init Akt=340.0 dAkt/dt=( 1.0 * AktSynthe) + (-1.0 * Hsp90AktB) + ( 1.0 * Hsp90AktR) + ( 1.0 * AktProt_1) # Species: id = Akt_Hsp90, name = Akt_Hsp90, affected by kineticLaw init Akt_Hsp90=30.0 dAkt_Hsp90/dt=( 1.0 * Hsp90AktB) + (-1.0 * Hsp90AktR) + (-1.0 * CHIPbindi) + ( 1.0 * CHIPrelea) # Species: id = CHIP, name = CHIP, affected by kineticLaw init CHIP=255.0 dCHIP/dt=(-1.0 * CHIPbindi) + ( 1.0 * CHIPrelea) + ( 1.0 * AktProtea) # Species: id = Akt_CHIP_Hsp90, name = Akt_CHIP_Hsp90, affected by kineticLaw par Akt_CHIP_=80.0 aux Akt_CHIP_=Akt_CHIP_ dAkt_CHIP_/dt=( 1.0 * CHIPbindi) + (-1.0 * CHIPrelea) + (-1.0 * AktProtea) # Species: id = Akt_Proteasome, name = Akt_Proteasome, affected by kineticLaw par Akt_Prote=0.0 aux Akt_Prote=Akt_Prote dAkt_Prote/dt=( 1.0 * AktProtea) + (-1.0 * AktProt_1) + (-1.0 * AktDegrad) # Species: id = Hsf1, name = Hsf1, affected by kineticLaw init Hsf1=5.0 dHsf1/dt=(-1.0 * Hsp90HSF1) + ( 1.0 * Hsp90HS_1) + (-2.0 * dimerisat) + (-1.0 * trimerisa) + ( 1.0 * deTrimeri) + ( 2.0 * deDimeris) # Species: id = Hsf1_Hsp90, name = Hsf1_Hsp90, affected by kineticLaw par Hsf1_Hsp9=95.0 aux Hsf1_Hsp9=Hsf1_Hsp9 dHsf1_Hsp9/dt=( 1.0 * Hsp90HSF1) + (-1.0 * Hsp90HS_1) # Species: id = Hsp90_MisP, name = Hsp90_MisP, affected by kineticLaw par Hsp90_Mis=470.0 aux Hsp90_Mis=Hsp90_Mis dHsp90_Mis/dt=( 1.0 * Hsp90MisP) + (-1.0 * Hsp90unsu) + (-1.0 * Hsp90refo) + (-1.0 * MisPPro_1) # Species: id = Hsp70_MisP, name = Hsp70_MisP, affected by kineticLaw par Hsp70_Mis=410.0 aux Hsp70_Mis=Hsp70_Mis dHsp70_Mis/dt=( 1.0 * Hsp70MisP) + (-1.0 * Hsp70unsu) + (-1.0 * Hsp70refo) + (-1.0 * MisPProte) # Species: id = Hsf1_Hsf1_Hsf1, name = Hsf1_Hsf1_Hsf1, affected by kineticLaw init Hsf1_Hsf1=0.0 dHsf1_Hsf1/dt=( 1.0 * trimerisa) + (-1.0 * deTrimeri) + (-1.0 * HSE70TriH) + ( 1.0 * HSE70Tr_1) + (-1.0 * HSE90TriH) + ( 1.0 * HSE90Tr_1) + (-1.0 * Hsf1_Hs_3) + ( 1.0 * Hsf1_Hs_4) # Species: id = Hsf1_Hsf1_Hsf1_P, name = Hsf1_Hsf1_Hsf1_P, affected by kineticLaw par Hsf1_Hs_1=0.0 aux Hsf1_Hs_1=Hsf1_Hs_1 dHsf1_Hs_1/dt=( 1.0 * Hsf1_Hs_3) + (-1.0 * Hsf1_Hs_4) + (-1.0 * HSE70Phos) + ( 1.0 * HSE70Ph_1) + (-1.0 * HSE90Phos) + ( 1.0 * HSE90Ph_1) # Species: id = Hsf1_Hsf1, name = Hsf1_Hsf1, affected by kineticLaw par Hsf1_Hs_2=0.0 aux Hsf1_Hs_2=Hsf1_Hs_2 dHsf1_Hs_2/dt=( 1.0 * dimerisat) + (-1.0 * trimerisa) + ( 1.0 * deTrimeri) + (-1.0 * deDimeris) # Species: id = HSEHsp70, name = HSEHsp70, affected by kineticLaw init HSEHsp70=2.0 dHSEHsp70/dt=(-1.0 * HSE70TriH) + ( 1.0 * HSE70Tr_1) + (-1.0 * HSE70Phos) + ( 1.0 * HSE70Ph_1) # Species: id = HSEHsp90, name = HSEHsp90, affected by kineticLaw init HSEHsp90=2.0 dHSEHsp90/dt=(-1.0 * HSE90TriH) + ( 1.0 * HSE90Tr_1) + (-1.0 * HSE90Phos) + ( 1.0 * HSE90Ph_1) # Species: id = HSEHsp70_Hsf1_Hsf1_Hsf1, name = HSEHsp70_Hsf1_Hsf1_Hsf1, affected by kineticLaw par HSEHsp70_=0.0 aux HSEHsp70_=HSEHsp70_ dHSEHsp70_/dt=( 1.0 * HSE70TriH) + (-1.0 * HSE70Tr_1) # Species: id = HSEHsp70_Hsf1_Hsf1_Hsf1_P, name = HSEHsp70_Hsf1_Hsf1_Hsf1_P, affected by kineticLaw par HSEHsp7_1=0.0 aux HSEHsp7_1=HSEHsp7_1 dHSEHsp7_1/dt=( 1.0 * HSE70Phos) + (-1.0 * HSE70Ph_1) + (-1.0 * Hsp70Upre) + ( 1.0 * Hsp70Upre) # Species: id = HSEHsp90_Hsf1_Hsf1_Hsf1, name = HSEHsp90_Hsf1_Hsf1_Hsf1, affected by kineticLaw par HSEHsp90_=0.0 aux HSEHsp90_=HSEHsp90_ dHSEHsp90_/dt=( 1.0 * HSE90TriH) + (-1.0 * HSE90Tr_1) # Species: id = HSEHsp90_Hsf1_Hsf1_Hsf1_P, name = HSEHsp90_Hsf1_Hsf1_Hsf1_P, affected by kineticLaw par HSEHsp9_1=0.0 aux HSEHsp9_1=HSEHsp9_1 dHSEHsp9_1/dt=( 1.0 * HSE90Phos) + (-1.0 * HSE90Ph_1) + (-1.0 * Hsp90Upre) + ( 1.0 * Hsp90Upre) # Species: id = Jnk, name = Jnk, affected by kineticLaw init Jnk=100.0 dJnk/dt=(-1.0 * JnkPhosph) + ( 1.0 * JNKDephos) # Species: id = Jnk_P, name = Jnk_P, affected by kineticLaw init Jnk_P=0.0 dJnk_P/dt=( 1.0 * JnkPhosph) + (-1.0 * JNKDephos) + (-1.0 * JnkCellDe) + ( 1.0 * JnkCellDe) # Species: id = Ppx, name = Ppx, affected by kineticLaw init Ppx=0.0 dPpx/dt=(-1.0 * Hsp70_P_1) + ( 1.0 * Hsp70_P_2) # Species: id = Mkp1, name = Mkp1, affected by kineticLaw init Mkp1=0.0 dMkp1/dt=( 1.0 * Mkp1Synth) + (-1.0 * Mkp1Prote) + (-1.0 * Mkp1Phosp) + ( 1.0 * Mkp1Depho) # Species: id = Mkp1_P, name = Mkp1_P, affected by kineticLaw init Mkp1_P=100.0 dMkp1_P/dt=(-1.0 * JNKDephos) + ( 1.0 * JNKDephos) + (-1.0 * p38DePhos) + ( 1.0 * p38DePhos) + ( 1.0 * Mkp1Phosp) + (-1.0 * Mkp1Depho) # Species: id = Mkp1_Proteasome, name = Mkp1_Proteasome, affected by kineticLaw par Mkp1_Prot=0.0 aux Mkp1_Prot=Mkp1_Prot dMkp1_Prot/dt=( 1.0 * Mkp1Prote) + (-1.0 * Mkp1Degra) # Species: id = Hsp70_Ppx, name = Hsp70_Ppx, affected by kineticLaw init Hsp70_Ppx=100.0 dHsp70_Ppx/dt=(-1.0 * Hsf1_Hs_4) + ( 1.0 * Hsf1_Hs_4) + ( 1.0 * Hsp70_P_1) + (-1.0 * Hsp70_P_2) # Species: id = Pkc, name = Pkc, affected by kineticLaw init Pkc=100.0 dPkc/dt=(-1.0 * Hsf1_Hs_3) + ( 1.0 * Hsf1_Hs_3) # Species: id = p38, name = p38, affected by kineticLaw init p38=100.0 dp38/dt=(-1.0 * p38Phosph) + ( 1.0 * p38DePhos) # Species: id = p38_P, name = p38_P, affected by kineticLaw init p38_P=0.0 dp38_P/dt=( 1.0 * p38Phosph) + (-1.0 * p38DePhos) + (-1.0 * p38ROSpro) + ( 1.0 * p38ROSpro) + (-1.0 * p38CellDe) + ( 1.0 * p38CellDe) # Species: id = Proteasome, name = Proteasome, affected by kineticLaw par Proteasom=500.0 aux Proteasom=Proteasom dProteasom/dt=(-1.0 * Hsp90Prot) + ( 1.0 * Hsp90Degr) + (-1.0 * Hsp70Prot) + ( 1.0 * Hsp70Degr) + (-1.0 * MisPProte) + (-1.0 * MisPPro_1) + ( 1.0 * MisPDegra) + (-1.0 * Proteas_1) + (-1.0 * AktProtea) + ( 1.0 * AktProt_1) + ( 1.0 * AktDegrad) + (-1.0 * Mkp1Prote) + ( 1.0 * Mkp1Degra) + (-1.0 * Hsp70DamP) + (-1.0 * Hsp90DamP) # Species: id = MisP_Proteasome, name = MisP_Proteasome, affected by kineticLaw par MisP_Prot=0.0 aux MisP_Prot=MisP_Prot dMisP_Prot/dt=( 1.0 * MisPProte) + ( 1.0 * MisPPro_1) + (-1.0 * MisPDegra) # Species: id = AggP, name = AggP, affected by kineticLaw init AggP=0.0 dAggP/dt=( 1.0 * Aggregati) + (-1.0 * Sequester) + (-1.0 * Proteas_1) + (-1.0 * ROSgenera) + ( 1.0 * ROSgenera) + ( 1.0 * Hsp70Da_1) + (-1.0 * Hsp70DamI) + ( 1.0 * Hsp90Da_1) + (-1.0 * Hsp90DamI) # Species: id = SeqAggP, name = SeqAggP, affected by kineticLaw init SeqAggP=0.0 dSeqAggP/dt=( 1.0 * Sequester) + (-1.0 * Inclusion) + ( 2.0 * Inclusion) + ( 1.0 * Hsp70DamI) + ( 1.0 * Hsp90DamI) + (-1.0 * Hsp70DamS) + ( 2.0 * Hsp70DamS) + (-1.0 * Hsp90DamS) + ( 2.0 * Hsp90DamS) # Species: id = AggP_Proteasome, name = AggP_Proteasome, affected by kineticLaw par AggP_Prot=0.0 aux AggP_Prot=AggP_Prot dAggP_Prot/dt=( 1.0 * Proteas_1) + (-1.0 * ROSgene_1) + ( 1.0 * ROSgene_1) + (-1.0 * PICellDea) + ( 1.0 * PICellDea) # Species: id = ROS, name = ROS, affected by kineticLaw init ROS=10.0 dROS/dt=(-1.0 * Misfoldin) + ( 1.0 * Misfoldin) + ( 1.0 * radicalFo) + (-1.0 * radicalSc) + (-1.0 * JnkPhosph) + ( 1.0 * JnkPhosph) + (-1.0 * p38Phosph) + ( 1.0 * p38Phosph) + ( 1.0 * ROSgenera) + ( 1.0 * ROSgene_1) + (-1.0 * Mkp1Depho) + ( 1.0 * Mkp1Depho) + ( 1.0 * p38ROSpro) + (-1.0 * Hsp70Dama) + ( 1.0 * Hsp70Dama) + (-1.0 * Hsp90Dama) + ( 1.0 * Hsp90Dama) # Species: id = ATP, name = ATP par ATP=10000.0 aux ATP=ATP #WARNING speciesID: ATP, constant= false , boundaryCondition = true but is not involved in assignmentRule, rateRule or events ! # Species: id = ADP, name = ADP par ADP=1000.0 aux ADP=ADP #WARNING speciesID: ADP, constant= false , boundaryCondition = true but is not involved in assignmentRule, rateRule or events ! # Species: id = Source, name = Source par Source=1.0 aux Source=Source #WARNING speciesID: Source, constant= false , boundaryCondition = true but is not involved in assignmentRule, rateRule or events ! # Species: id = Sink, name = Sink par Sink=1.0 aux Sink=Sink #WARNING speciesID: Sink, constant= false , boundaryCondition = true but is not involved in assignmentRule, rateRule or events ! # Species: id = p38Death, name = p38Death, affected by kineticLaw init p38Death=0.0 dp38Death/dt=( 1.0 * p38CellDe) # Species: id = JNKDeath, name = JNKDeath, affected by kineticLaw init JNKDeath=0.0 dJNKDeath/dt=( 1.0 * JnkCellDe) # Species: id = PIDeath, name = PIDeath, affected by kineticLaw init PIDeath=0.0 dPIDeath/dt=( 1.0 * PICellDea) # Species: id = CellDeath, name = CellDeath, affected by kineticLaw init CellDeath=0.0 dCellDeath/dt=( 1.0 * p38CellDe) + ( 1.0 * JnkCellDe) + ( 1.0 * PICellDea) # event : DeathOfCell DeathOfCe=if (CellDeath >= 1) then (1.5) else (0.2) global 1 {DeathOfCe - 1.1} {kalive=0} @ meth=cvode, tol=1e-6, atol=1e-8 # @ maxstor=1e6 @ bound=40000, total=200 done