RIGHT 0 conversion reaction 149 species 148 STOICHIOMETRY
type: Stoichiometry
physical entity: species_148
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/3.1.3.48
type: UnificationXref
id: 3.1.3.48
db: Enzyme Nomenclature

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_14
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

RIGHT 0 conversion reaction 67 species 71 STOICHIOMETRY
type: Stoichiometry
physical entity: species_71
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 131 species 134 STOICHIOMETRY
type: Stoichiometry
physical entity: species_134
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 100 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

species_147
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
cellular location: Cell

LEFT 0 conversion reaction 124 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 122 species 124 STOICHIOMETRY
type: Stoichiometry
physical entity: species_124
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

RIGHT 0 conversion reaction 203 species 193 STOICHIOMETRY
type: Stoichiometry
physical entity: species_193
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 22 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 22 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 70 species 74 STOICHIOMETRY
type: Stoichiometry
physical entity: species_74
stoichiometric coefficient: 1.0

species_18
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP
cellular location: Cell

species_34
type: PhysicalEntity
member physical entity: ppMEK-pERK
cellular location: Cell

LEFT 1 conversion reaction 120 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 87 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 143 species 140 STOICHIOMETRY
type: Stoichiometry
physical entity: species_140
stoichiometric coefficient: 1.0

species_171
type: PhysicalEntity
member physical entity: species 171
cellular location: Cell

species_93
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF
cellular location: Cell

species_145
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

species_173
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdRhoGTPef
cellular location: Cell

http://identifiers.org/ec-code/3.1.3.67
type: UnificationXref
id: 3.1.3.67
db: Enzyme Nomenclature

RIGHT 1 conversion reaction 200 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 145 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 74 species 77 STOICHIOMETRY
type: Stoichiometry
physical entity: species_77
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 19 species 22 STOICHIOMETRY
type: Stoichiometry
physical entity: species_22
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 15 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

species_28
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

LEFT 0 conversion reaction 49 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 199 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_41
type: PhysicalEntity
member physical entity: MKP3
cellular location: Cell

RIGHT 0 conversion reaction 62 species 67 STOICHIOMETRY
type: Stoichiometry
physical entity: species_67
stoichiometric coefficient: 1.0

species_45
type: PhysicalEntity
member physical entity: RasGTP-RasGAP
cellular location: Cell

LEFT 0 conversion reaction 164 species 159 STOICHIOMETRY
type: Stoichiometry
physical entity: species_159
stoichiometric coefficient: 1.0

species_10
type: PhysicalEntity
member physical entity: pShc
cellular location: Cell

LEFT 0 conversion reaction 191 species 185 STOICHIOMETRY
type: Stoichiometry
physical entity: species_185
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 195 species 188 STOICHIOMETRY
type: Stoichiometry
physical entity: species_188
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 103 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_58
type: PhysicalEntity
member physical entity: Akt
cellular location: Cell

LEFT 0 conversion reaction 31 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 127 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

LEFT 0 conversion reaction 110 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

GO:0004445
type: UnificationXref
id: GO:0004445
db: Gene Ontology

RIGHT 0 conversion reaction 52 species 49 STOICHIOMETRY
type: Stoichiometry
physical entity: species_49
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_66
type: PhysicalEntity
member physical entity: pRaf-pAkt-PIP3
cellular location: Cell

species_67
type: PhysicalEntity
member physical entity: ppRaf
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

RIGHT 0 conversion reaction 133 species 136 STOICHIOMETRY
type: Stoichiometry
physical entity: species_136
stoichiometric coefficient: 1.0

species_97
type: PhysicalEntity
member physical entity: RhoGAP
cellular location: Cell

RIGHT 0 conversion reaction 147 species 147 STOICHIOMETRY
type: Stoichiometry
physical entity: species_147
stoichiometric coefficient: 1.0

species_17
type: PhysicalEntity
member physical entity: RasGDP
cellular location: Cell

species_88
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP-RasGTP
cellular location: Cell

species_134
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 7 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_166
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbcdef
cellular location: Cell

RIGHT 0 conversion reaction 55 species 59 STOICHIOMETRY
type: Stoichiometry
physical entity: species_59
stoichiometric coefficient: 1.0

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

species_168
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef
cellular location: Cell

species_165
type: PhysicalEntity
member physical entity: species 165
cellular location: Cell

GO:0019902
type: UnificationXref
id: GO:0019902
db: Gene Ontology

BIOMD0000000205
type: UnificationXref
id: BIOMD0000000205
db: BioModels Database

species_9
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc
cellular location: Cell

species_141
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

RIGHT 1 conversion reaction 38 species 41 STOICHIOMETRY
type: Stoichiometry
physical entity: species_41
stoichiometric coefficient: 1.0

species_77
type: PhysicalEntity
member physical entity: RacGTP
cellular location: Cell

RIGHT 0 conversion reaction 5 species 8 STOICHIOMETRY
type: Stoichiometry
physical entity: species_8
stoichiometric coefficient: 1.0

CHEBI:17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

species_87
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP
cellular location: Cell

RIGHT 0 conversion reaction 135 species 137 STOICHIOMETRY
type: Stoichiometry
physical entity: species_137
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 165 species 160 STOICHIOMETRY
type: Stoichiometry
physical entity: species_160
stoichiometric coefficient: 1.0

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

species_154
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP
cellular location: Cell

LEFT 0 conversion reaction 193 species 147 STOICHIOMETRY
type: Stoichiometry
physical entity: species_147
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 175 species 169 STOICHIOMETRY
type: Stoichiometry
physical entity: species_169
stoichiometric coefficient: 1.0

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

LEFT 0 conversion reaction 160 species 156 STOICHIOMETRY
type: Stoichiometry
physical entity: species_156
stoichiometric coefficient: 1.0

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

species_9
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc
cellular location: Cell

species_162
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef
cellular location: Cell

LEFT 0 conversion reaction 50 species 50 STOICHIOMETRY
type: Stoichiometry
physical entity: species_50
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 53 species 55 STOICHIOMETRY
type: Stoichiometry
physical entity: species_55
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_99
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2-pRhoGAP
cellular location: Cell

RIGHT 0 conversion reaction 0 species 2 STOICHIOMETRY
type: Stoichiometry
physical entity: species_2
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 45 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 150 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 32 species 37 STOICHIOMETRY
type: Stoichiometry
physical entity: species_37
stoichiometric coefficient: 1.0

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

RIGHT 3 conversion reaction 117 species 121 STOICHIOMETRY
type: Stoichiometry
physical entity: species_121
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 104 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

species_142
type: PhysicalEntity
member physical entity: species 142
cellular location: Cell

species_125
type: PhysicalEntity
member physical entity: MPase
cellular location: Cell

RIGHT 1 conversion reaction 32 species 36 STOICHIOMETRY
type: Stoichiometry
physical entity: species_36
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 11 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

species_8
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Shc
cellular location: Cell

LEFT 1 conversion reaction 180 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

species_145
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

RIGHT 1 conversion reaction 99 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 145 species 145 STOICHIOMETRY
type: Stoichiometry
physical entity: species_145
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 121 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

species_159
type: PhysicalEntity
member physical entity: species 159
cellular location: Cell

species_156
type: PhysicalEntity
member physical entity: species 156
cellular location: Cell

RIGHT 0 conversion reaction 18 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 113 species 114 STOICHIOMETRY
type: Stoichiometry
physical entity: species_114
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 150 species 148 STOICHIOMETRY
type: Stoichiometry
physical entity: species_148
stoichiometric coefficient: 1.0

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

LEFT 0 conversion reaction 75 species 77 STOICHIOMETRY
type: Stoichiometry
physical entity: species_77
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

GO:0043241
type: UnificationXref
id: GO:0043241
db: Gene Ontology

RIGHT 1 conversion reaction 7 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 114 species 116 STOICHIOMETRY
type: Stoichiometry
physical entity: species_116
stoichiometric coefficient: 1.0

species_112
type: PhysicalEntity
member physical entity: pSrc-TP7
cellular location: Cell

species_185
type: PhysicalEntity
member physical entity: species 185
cellular location: Cell

LEFT 0 conversion reaction 107 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_188
type: PhysicalEntity
member physical entity: species 188
cellular location: Cell

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

species_115
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85
cellular location: Cell

CHEBI:16618
type: UnificationXref
id: CHEBI:16618
db: ChEBI

LEFT 1 conversion reaction 94 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 114 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 21 species 24 STOICHIOMETRY
type: Stoichiometry
physical entity: species_24
stoichiometric coefficient: 1.0

species_75
type: PhysicalEntity
member physical entity: RacGDP
cellular location: Cell

species_122
type: PhysicalEntity
member physical entity: Pro-EGFR
cellular location: Cell

species_124
type: PhysicalEntity
member physical entity: pEPn
cellular location: Cell

species_53
type: PhysicalEntity
member physical entity: TP4
cellular location: Cell

LEFT 0 conversion reaction 176 species 169 STOICHIOMETRY
type: Stoichiometry
physical entity: species_169
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 162 species 158 STOICHIOMETRY
type: Stoichiometry
physical entity: species_158
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 30 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_87
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP
cellular location: Cell

LEFT 0 conversion reaction 4 species 6 STOICHIOMETRY
type: Stoichiometry
physical entity: species_6
stoichiometric coefficient: 1.0

species_24
type: PhysicalEntity
member physical entity: Raf-RasGTP
cellular location: Cell

RIGHT 0 conversion reaction 173 species 167 STOICHIOMETRY
type: Stoichiometry
physical entity: species_167
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 38 species 42 STOICHIOMETRY
type: Stoichiometry
physical entity: species_42
stoichiometric coefficient: 1.0

species_59
type: PhysicalEntity
member physical entity: Akt-PIP3
cellular location: Cell

species_180
type: PhysicalEntity
member physical entity: species 180
cellular location: Cell

species_183
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef
cellular location: Cell

RIGHT 0 conversion reaction 71 species 76 STOICHIOMETRY
type: Stoichiometry
physical entity: species_76
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 77 species 78 STOICHIOMETRY
type: Stoichiometry
physical entity: species_78
stoichiometric coefficient: 1.0

species_50
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-PI3K
cellular location: Cell

LEFT 1 conversion reaction 61 species 62 STOICHIOMETRY
type: Stoichiometry
physical entity: species_62
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 116 species 119 STOICHIOMETRY
type: Stoichiometry
physical entity: species_119
stoichiometric coefficient: 1.0

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

http://identifiers.org/ec-code/3.1.3.16
type: UnificationXref
id: 3.1.3.16
db: Enzyme Nomenclature

species_151
type: PhysicalEntity
member physical entity: species 151
cellular location: Cell

RIGHT 0 conversion reaction 59 species 65 STOICHIOMETRY
type: Stoichiometry
physical entity: species_65
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 34 species 38 STOICHIOMETRY
type: Stoichiometry
physical entity: species_38
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 72 species 77 STOICHIOMETRY
type: Stoichiometry
physical entity: species_77
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 25 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 50 species 52 STOICHIOMETRY
type: Stoichiometry
physical entity: species_52
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 79 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q02750

EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q02750

RIGHT 0 conversion reaction 28 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: P98077

R117
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 116 species 116 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 116 species 119 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 116 species 117 STOICHIOMETRY
right: species_119
left: species_116
left: species_117

R116
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 115 species 118 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 115 species 115 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 115 species 117 STOICHIOMETRY
right: species_118
left: species_117
left: species_115

LEFT 0 conversion reaction 96 species 87 STOICHIOMETRY
type: Stoichiometry
physical entity: species_87
stoichiometric coefficient: 1.0

R119
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 118 species 119 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion reaction 118 species 16 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 118 species 120 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 118 species 114 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 118 species 117 STOICHIOMETRY
right: species_120
right: species_16
right: species_114
right: species_117
left: species_119

R118
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 117 species 118 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 117 species 114 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 117 species 117 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 117 species 120 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion reaction 117 species 121 STOICHIOMETRY
right: species_120
right: species_121
right: species_114
right: species_117
left: species_118

EGF-pEGFR-2-Grb2-MEKK1apRafbcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049

EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef
type: Protein
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q02750

R120
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 119 species 1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 119 species 122 STOICHIOMETRY
right: species_1
spontaneous: true
left: species_122
conversion direction: RIGHT_TO_LEFT

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

R111
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 110 species 112 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 110 species 111 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 110 species 101 STOICHIOMETRY
right: species_112
spontaneous: true
left: species_101
left: species_111
conversion direction: LEFT_TO_RIGHT

R113
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 112 species 113 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 112 species 107 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 112 species 111 STOICHIOMETRY
right: species_107
right: species_111
spontaneous: true
left: species_113
conversion direction: RIGHT_TO_LEFT

R112
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 111 species 113 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 111 species 112 STOICHIOMETRY
right: species_113
left: species_112

R115
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 114 species 21 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 114 species 114 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 114 species 116 STOICHIOMETRY
right: species_116
left: species_114
left: species_21

R114
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 113 species 114 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 113 species 15 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 113 species 115 STOICHIOMETRY
right: species_115
left: species_15
left: species_114

RIGHT 0 conversion reaction 110 species 112 STOICHIOMETRY
type: Stoichiometry
physical entity: species_112
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 41 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 141 species 142 STOICHIOMETRY
type: Stoichiometry
physical entity: species_142
stoichiometric coefficient: 1.0

species_71
type: PhysicalEntity
member physical entity: pPTEN
cellular location: Cell

RIGHT 2 conversion reaction 200 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

R128
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 127 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 127 species 105 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 127 species 129 STOICHIOMETRY
right: species_35
right: species_105
spontaneous: true
left: species_129
conversion direction: RIGHT_TO_LEFT

EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P62993
xref: P07522
xref: Q13233

R127
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 126 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 126 species 68 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 126 species 129 STOICHIOMETRY
right: species_129
spontaneous: true
left: species_68
left: species_35
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion reaction 166 species 155 STOICHIOMETRY
type: Stoichiometry
physical entity: species_155
stoichiometric coefficient: 1.0

R130
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 129 species 131 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 129 species 132 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 129 species 9 STOICHIOMETRY
right: species_132
spontaneous: true
left: species_9
left: species_131
conversion direction: RIGHT_TO_LEFT

R129
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 128 species 12 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 128 species 131 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 128 species 130 STOICHIOMETRY
right: species_131
spontaneous: true
left: species_12
left: species_130
conversion direction: LEFT_TO_RIGHT

EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

species_55
type: PhysicalEntity
member physical entity: PIP2
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

R122
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 121 species 123 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 121 species 68 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 121 species 124 STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.1
right: species_68
right: species_124
spontaneous: true
left: species_123
conversion direction: RIGHT_TO_LEFT

R121
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 120 species 68 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 120 species 117 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 120 species 123 STOICHIOMETRY
right: species_123
spontaneous: true
left: species_117
left: species_68
conversion direction: LEFT_TO_RIGHT

R124
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 123 species 117 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 123 species 127 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 123 species 125 STOICHIOMETRY
right: species_125
right: species_117
spontaneous: true
left: species_127
conversion direction: RIGHT_TO_LEFT

species_136
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
cellular location: Cell

R123
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 122 species 124 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 122 species 125 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 122 species 126 STOICHIOMETRY
right: species_126
spontaneous: true
left: species_125
left: species_124
conversion direction: LEFT_TO_RIGHT

LEFT 1 conversion reaction 92 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

R126
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 125 species 84 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 125 species 19 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 125 species 128 STOICHIOMETRY
right: species_84
right: species_19
spontaneous: true
left: species_128
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion reaction 102 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

R125
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 124 species 128 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 124 species 94 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 124 species 19 STOICHIOMETRY
right: species_128
spontaneous: true
left: species_19
left: species_94
conversion direction: RIGHT_TO_LEFT

LEFT 1 conversion reaction 172 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 128 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

species_27
type: PhysicalEntity
member physical entity: pRaf-MEK
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

species_55
type: PhysicalEntity
member physical entity: PIP2
cellular location: Cell

RIGHT 0 conversion reaction 117 species 120 STOICHIOMETRY
type: Stoichiometry
physical entity: species_120
stoichiometric coefficient: 1.0

R139
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 138 species 139 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 138 species 133 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 138 species 30 STOICHIOMETRY
right: species_133
right: species_30
left: species_139

R138
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 137 species 138 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 137 species 139 STOICHIOMETRY
right: species_139
left: species_138

EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q02750
xref: P28482

EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef
type: Protein
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q02750
xref: P28482

R140
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 139 species 23 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 139 species 140 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 139 species 132 STOICHIOMETRY
right: species_140
left: species_23
left: species_132

RIGHT 0 conversion reaction 200 species 147 STOICHIOMETRY
type: Stoichiometry
physical entity: species_147
stoichiometric coefficient: 1.0

GO:0007173
type: UnificationXref
id: GO:0007173
db: Gene Ontology

species_5
type: PhysicalEntity
member physical entity: SHP
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q02750
xref: P28482

R131
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 130 species 131 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 130 species 133 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 130 species 4 STOICHIOMETRY
right: species_133
spontaneous: true
left: species_131
left: species_4
conversion direction: RIGHT_TO_LEFT

species_40
type: PhysicalEntity
member physical entity: pMEK-PP2A
cellular location: Cell

R133
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 132 species 135 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 132 species 134 STOICHIOMETRY
right: species_135
left: species_134

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

R132
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 131 species 134 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 131 species 26 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 131 species 132 STOICHIOMETRY
right: species_134
left: species_26
left: species_132

R135
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 134 species 136 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 134 species 132 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 134 species 30 STOICHIOMETRY
right: species_30
right: species_132
left: species_136

EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q02750
xref: P28482

R134
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 133 species 135 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 133 species 136 STOICHIOMETRY
right: species_136
left: species_135

R137
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 136 species 137 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 136 species 138 STOICHIOMETRY
right: species_138
left: species_137

R136
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 135 species 133 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 135 species 137 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 135 species 26 STOICHIOMETRY
right: species_137
left: species_26
left: species_133

RIGHT 1 conversion reaction 40 species 41 STOICHIOMETRY
type: Stoichiometry
physical entity: species_41
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 177 species 134 STOICHIOMETRY
type: Stoichiometry
physical entity: species_134
stoichiometric coefficient: 1.0

R151
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 150 species 26 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 150 species 148 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 150 species 149 STOICHIOMETRY
right: species_149
left: species_148
left: species_26

LEFT 0 conversion reaction 79 species 85 STOICHIOMETRY
type: Stoichiometry
physical entity: species_85
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 168 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 108 species 109 STOICHIOMETRY
type: Stoichiometry
physical entity: species_109
stoichiometric coefficient: 1.0

EGF-pEGFR-2-Grb2-MEKK1abppMEKcdRhoGTPef
type: Complex
xref: P61586
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q02750

LEFT 1 conversion reaction 51 species 53 STOICHIOMETRY
type: Stoichiometry
physical entity: species_53
stoichiometric coefficient: 1.0

R150
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 149 species 19 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 149 species 148 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 149 species 132 STOICHIOMETRY
right: species_148
spontaneous: true
left: species_132
left: species_19
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 186 species 181 STOICHIOMETRY
type: Stoichiometry
physical entity: species_181
stoichiometric coefficient: 1.0

R149
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 148 species 144 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 148 species 147 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 148 species 30 STOICHIOMETRY
right: species_144
right: species_30
left: species_147

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1abMEKcdRhoGTPef
type: Complex
xref: P61586
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q02750

EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPef
type: Complex
xref: P61586
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049

LEFT 0 conversion reaction 40 species 43 STOICHIOMETRY
type: Stoichiometry
physical entity: species_43
stoichiometric coefficient: 1.0

R142
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 141 species 141 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 141 species 142 STOICHIOMETRY
right: species_142
left: species_141

R141
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 140 species 140 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 140 species 26 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 140 species 141 STOICHIOMETRY
right: species_141
left: species_140
left: species_26

R144
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 143 species 143 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 143 species 140 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 143 species 30 STOICHIOMETRY
right: species_30
right: species_140
left: species_143

R143
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 142 species 143 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 142 species 142 STOICHIOMETRY
right: species_143
left: species_142

R146
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 145 species 145 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 145 species 26 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 145 species 144 STOICHIOMETRY
right: species_145
left: species_144
left: species_26

R145
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 144 species 133 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 144 species 144 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 144 species 23 STOICHIOMETRY
right: species_144
left: species_23
left: species_133

LEFT 0 conversion reaction 6 species 8 STOICHIOMETRY
type: Stoichiometry
physical entity: species_8
stoichiometric coefficient: 1.0

R148
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 147 species 146 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 147 species 147 STOICHIOMETRY
right: species_147
left: species_146

R147
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 146 species 146 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 146 species 145 STOICHIOMETRY
right: species_146
left: species_145

LEFT 0 conversion reaction 101 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

species_47
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_23
type: PhysicalEntity
member physical entity: Raf
cellular location: Cell

species_71
type: PhysicalEntity
member physical entity: pPTEN
cellular location: Cell

LEFT 0 conversion reaction 70 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

species_24
type: PhysicalEntity
member physical entity: Raf-RasGTP
cellular location: Cell

species_69
type: PhysicalEntity
member physical entity: PTEN
cellular location: Cell

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

species_189
type: PhysicalEntity
member physical entity: species 189
cellular location: Cell

RIGHT 0 conversion reaction 24 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

LEFT 1 conversion reaction 13 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 58 species 63 STOICHIOMETRY
type: Stoichiometry
physical entity: species_63
stoichiometric coefficient: 1.0

species_187
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef
cellular location: Cell

LEFT 0 conversion reaction 154 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 180 species 145 STOICHIOMETRY
type: Stoichiometry
physical entity: species_145
stoichiometric coefficient: 1.0

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

species_114
type: PhysicalEntity
member physical entity: Cbl-CIN85
cellular location: Cell

RIGHT 0 conversion reaction 171 species 162 STOICHIOMETRY
type: Stoichiometry
physical entity: species_162
stoichiometric coefficient: 1.0

species_151
type: PhysicalEntity
member physical entity: species 151
cellular location: Cell

RIGHT 1 conversion reaction 24 species 28 STOICHIOMETRY
type: Stoichiometry
physical entity: species_28
stoichiometric coefficient: 1.0

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

species_11
type: PhysicalEntity
member physical entity: pShc-SHP
cellular location: Cell

RIGHT 0 conversion reaction 178 species 172 STOICHIOMETRY
type: Stoichiometry
physical entity: species_172
stoichiometric coefficient: 1.0

species_135
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef
cellular location: Cell

species_17
type: PhysicalEntity
member physical entity: RasGDP
cellular location: Cell

species_53
type: PhysicalEntity
member physical entity: TP4
cellular location: Cell

species_160
type: PhysicalEntity
member physical entity: species 160
cellular location: Cell

RIGHT 1 conversion reaction 117 species 114 STOICHIOMETRY
type: Stoichiometry
physical entity: species_114
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 164 species 160 STOICHIOMETRY
type: Stoichiometry
physical entity: species_160
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 16 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 106 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

R106
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 105 species 106 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 105 species 105 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 105 species 86 STOICHIOMETRY
right: species_106
left: species_105
left: species_86

R105
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 104 species 82 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 104 species 104 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 104 species 95 STOICHIOMETRY
xref: GO:0005096
right: species_82
right: species_95
left: species_104

R108
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 107 species 4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 107 species 107 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 107 species 108 STOICHIOMETRY
xref: GO:0006461
right: species_108
left: species_4
left: species_107

R107
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 106 species 106 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 106 species 68 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 106 species 86 STOICHIOMETRY
right: species_68
right: species_86
left: species_106

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

LEFT 0 conversion reaction 82 species 87 STOICHIOMETRY
type: Stoichiometry
physical entity: species_87
stoichiometric coefficient: 1.0

species_103
type: PhysicalEntity
member physical entity: pSrc-RhoGAP
cellular location: Cell

R110
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 109 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 109 species 101 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 109 species 110 STOICHIOMETRY
right: species_110
right: species_101
left: species_4

species_38
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

R109
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 108 species 108 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 108 species 109 STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.10.1
right: species_109
left: species_108

R102
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 101 species 103 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 101 species 97 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 101 species 101 STOICHIOMETRY
right: species_103
left: species_97
left: species_101

R101
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 100 species 94 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 100 species 84 STOICHIOMETRY
right: species_94
left: species_84

R104
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 103 species 95 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 103 species 104 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 103 species 86 STOICHIOMETRY
right: species_104
left: species_95
left: species_86

R103
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 102 species 103 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 102 species 95 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 102 species 101 STOICHIOMETRY
xref: GO:0004715
xref: http://identifiers.org/ec-code/2.7.10.2
right: species_101
right: species_95
left: species_103

species_104
type: PhysicalEntity
member physical entity: pRhoGAP-RhoGTP
cellular location: Cell

species_94
type: PhysicalEntity
member physical entity: RhoGEF
cellular location: Cell

species_47
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

http://identifiers.org/pubmed/14751248
type: PublicationXref
id: 14751248
db: PubMed

species_152
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

LEFT 0 conversion reaction 28 species 32 STOICHIOMETRY
type: Stoichiometry
physical entity: species_32
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 43 species 45 STOICHIOMETRY
type: Stoichiometry
physical entity: species_45
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 2 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 141 species 141 STOICHIOMETRY
type: Stoichiometry
physical entity: species_141
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

LEFT 0 conversion reaction 41 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 198 species 190 STOICHIOMETRY
type: Stoichiometry
physical entity: species_190
stoichiometric coefficient: 1.0

species_148
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

LEFT 0 conversion reaction 199 species 173 STOICHIOMETRY
type: Stoichiometry
physical entity: species_173
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 169 species 163 STOICHIOMETRY
type: Stoichiometry
physical entity: species_163
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 130 species 131 STOICHIOMETRY
type: Stoichiometry
physical entity: species_131
stoichiometric coefficient: 1.0

species_143
type: PhysicalEntity
member physical entity: species 143
cellular location: Cell

LEFT 0 conversion reaction 98 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

species_161
type: PhysicalEntity
member physical entity: species 161
cellular location: Cell

RIGHT 0 conversion reaction 86 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

species_83
type: PhysicalEntity
member physical entity: RhoGDP-RhoGDI
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_56
type: PhysicalEntity
member physical entity: pPI3K-PIP2
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

RIGHT 0 conversion reaction 57 species 62 STOICHIOMETRY
type: Stoichiometry
physical entity: species_62
stoichiometric coefficient: 1.0

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

pRhoGAP-RhoGTP
type: Complex
xref: P61586

ROK
type: Protein
xref: Q13464

pSrc-RhoGEF
type: Complex
xref: P12931
xref: Q9NZN5

pSrc-RhoGAP
type: Protein
xref: P12931

EGF-pEGFR-2-Src
type: Complex
xref: P12931
xref: Q9QX70
xref: P07522

EGF-pEGFR-2-pSrc
type: Complex
xref: P12931
xref: Q9QX70
xref: P07522

RhoGTP-ROK
type: Complex
xref: P61586
xref: Q13464

CHEBI:16152
type: UnificationXref
id: CHEBI:16152
db: ChEBI

Src
type: Protein
xref: P12931

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

LEFT 1 conversion reaction 167 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

EGF-pEGFR-2-RasGAP-SHP2
type: Complex
xref: Q9QX70
xref: Q06124
xref: P07522
xref: P20936

pSrc
type: Protein
xref: P12931

LEFT 0 conversion reaction 138 species 139 STOICHIOMETRY
type: Stoichiometry
physical entity: species_139
stoichiometric coefficient: 1.0

species_40
type: PhysicalEntity
member physical entity: pMEK-PP2A
cellular location: Cell

RIGHT 0 conversion reaction 194 species 188 STOICHIOMETRY
type: Stoichiometry
physical entity: species_188
stoichiometric coefficient: 1.0

species_167
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef
cellular location: Cell

LEFT 0 conversion reaction 73 species 78 STOICHIOMETRY
type: Stoichiometry
physical entity: species_78
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 162 species 151 STOICHIOMETRY
type: Stoichiometry
physical entity: species_151
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 131 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

Q9QX70
type: UnificationXref
id: Q9QX70
db: UniProt Knowledgebase

species_140
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
cellular location: Cell

RIGHT 1 conversion reaction 171 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_113
type: PhysicalEntity
member physical entity: Src-TP7
cellular location: Cell

pEPn-MPase
type: Complex
xref: Q99962

pEPn-Mpase
type: Complex
xref: Q99962

pEPn
type: Protein
xref: Q99962

MPase
type: PhysicalEntity

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

RIGHT 1 conversion reaction 162 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

Ras-GTP-RhoGEF
type: PhysicalEntity

ppERK-pROK
type: Complex
xref: Q13464
xref: P28482

Pro-EGFR
type: Complex
xref: Q9QX70

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

pROK-EPn
type: Complex
xref: Q13464
xref: Q99962

EGF-pEGFR-2-degrade
type: PhysicalEntity

pShc-Grb2-SOS
type: Complex
xref: P62993
xref: P98077
xref: Q07889

species_89
type: PhysicalEntity
member physical entity: EGF-pEGFR2-RasGAP
cellular location: Cell

RIGHT 1 conversion reaction 125 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

species_67
type: PhysicalEntity
member physical entity: ppRaf
cellular location: Cell

RIGHT 3 conversion reaction 118 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 78 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q07889
xref: Q96B97

EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q07889
xref: Q96B97

Src-TP7
type: Complex
xref: P12931

Cbl-CIN85
type: Protein
xref: Q96B97

EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q99962
xref: Q07889
xref: Q96B97

EPn
type: Protein
xref: Q99962

EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q99962
xref: Q07889
xref: Q96B97

TP7
type: PhysicalEntity

pSrc-TP7
type: Complex
xref: P12931

LEFT 0 conversion reaction 204 species 193 STOICHIOMETRY
type: Stoichiometry
physical entity: species_193
stoichiometric coefficient: 1.0

EGF-pEGRF-2
type: Complex
xref: Q9QX70
xref: P07522

RIGHT 1 conversion reaction 67 species 55 STOICHIOMETRY
type: Stoichiometry
physical entity: species_55
stoichiometric coefficient: 1.0

species_64
type: PhysicalEntity
member physical entity: Takt
cellular location: Cell

species_61
type: PhysicalEntity
member physical entity: Akt-PIP3-PDK1
cellular location: Cell

LEFT 0 conversion reaction 202 species 192 STOICHIOMETRY
type: Stoichiometry
physical entity: species_192
stoichiometric coefficient: 1.0

EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P62993
xref: P07522
xref: P98077
xref: Q13233

EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q13233
xref: Q02750

EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q13233
xref: Q02750

RIGHT 1 conversion reaction 20 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 184 species 180 STOICHIOMETRY
type: Stoichiometry
physical entity: species_180
stoichiometric coefficient: 1.0

EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q13233

EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: P98077
xref: Q13233
xref: Q02750

EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q13233

EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P04049
xref: Q13233
xref: Q02750

P60484
type: UnificationXref
id: P60484
db: UniProt Knowledgebase

LEFT 0 conversion reaction 90 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 157 species 154 STOICHIOMETRY
type: Stoichiometry
physical entity: species_154
stoichiometric coefficient: 1.0

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_36
type: PhysicalEntity
member physical entity: Pase
cellular location: Cell

species_181
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

RIGHT 3 conversion reaction 47 species 47 STOICHIOMETRY
type: Stoichiometry
physical entity: species_47
stoichiometric coefficient: 1.0

EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q13233
xref: Q02750

EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q13233
xref: Q02750

LEFT 0 conversion reaction 36 species 40 STOICHIOMETRY
type: Stoichiometry
physical entity: species_40
stoichiometric coefficient: 1.0

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q13233
xref: Q02750

MEKK1abcdef
type: Protein
xref: Q13233

EGF-pEGFR-2-Grb2-MEKK1abcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q13233

EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q13233
xref: Q02750

Grb2-MEKK1abcdef
type: Complex
xref: P62993
xref: Q13233

EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
type: Complex
xref: Q9QX70
xref: P62993
xref: P98077
xref: Q13233

species_2
type: PhysicalEntity
member physical entity: EGF-EGFR
cellular location: Cell

RacGEF
type: Protein
xref: Q15052

species_70
type: PhysicalEntity
member physical entity: pROK-PTEN
cellular location: Cell

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

pPTEN-PIP3
type: Complex
xref: P60484
xref: CHEBI:16618

pPTEN
type: Protein
xref: P60484

pROK-PTEN
type: Complex
xref: Q13464
xref: P60484

species_69
type: PhysicalEntity
member physical entity: PTEN
cellular location: Cell

RIGHT 1 conversion reaction 109 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

PTEN
type: Protein
xref: P60484

pROK
type: Protein
xref: Q13464

RIGHT 2 conversion reaction 87 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

ppRaf
type: Protein
xref: P04049

pRaf-pAkt-PIP3
type: Complex
xref: P04049
xref: CHEBI:16618
xref: P31749

pAkt-PIP3-Takt
type: Complex
xref: CHEBI:16618
xref: P31749

Takt
type: PhysicalEntity

pAkt
type: Protein
xref: P31749

pAkt-PIP3
type: Complex
xref: CHEBI:16618
xref: P31749

Akt-PIP3-PDK1
type: Complex
xref: O15530
xref: CHEBI:16618
xref: P31749

species_97
type: PhysicalEntity
member physical entity: RhoGAP
cellular location: Cell

PDK1
type: Protein
xref: O15530

LEFT 1 conversion reaction 139 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 145 species 144 STOICHIOMETRY
type: Stoichiometry
physical entity: species_144
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 203 species 177 STOICHIOMETRY
type: Stoichiometry
physical entity: species_177
stoichiometric coefficient: 1.0

Akt-PIP3
type: Complex
xref: CHEBI:16618
xref: P31749

Akt
type: Protein
xref: P31749

PIP3
type: SmallMolecule
xref: CHEBI:16618

pPI3K-PIP2
type: Complex
xref: Q8WYR1
xref: CHEBI:16152

PIP2
type: SmallMolecule
xref: CHEBI:16152

Q07889
type: UnificationXref
id: Q07889
db: UniProt Knowledgebase

pPI3K-TP4
type: Complex
xref: Q8WYR1

TP4
type: PhysicalEntity

pPI3K
type: Protein
xref: Q8WYR1

pRhoGAP
type: PhysicalEntity

RhoGEF
type: Protein
xref: Q9NZN5

EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: Q9NZN5
xref: P07522
xref: P98077

RIGHT 0 conversion reaction 129 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

EGF-pEGFR-2-Grb2-SHP2
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: P07522

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

EGF-pEGFR-2-pShc-Grb2-SHP2
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: P07522
xref: P98077

species_23
type: PhysicalEntity
member physical entity: Raf
cellular location: Cell

SHP2
type: Protein
xref: Q06124

RIGHT 1 conversion reaction 30 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

LEFT 0 conversion reaction 115 species 115 STOICHIOMETRY
type: Stoichiometry
physical entity: species_115
stoichiometric coefficient: 1.0

species_99
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2-pRhoGAP
cellular location: Cell

RIGHT 1 conversion reaction 15 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_50
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-PI3K
cellular location: Cell

RIGHT 1 conversion reaction 91 species 97 STOICHIOMETRY
type: Stoichiometry
physical entity: species_97
stoichiometric coefficient: 1.0

EGF-pEGFR2-RasGAP
type: Complex
xref: Q9QX70
xref: P07522
xref: P20936

EGF-pEGFR-2-RasGAP-RasGTP
type: Complex
xref: P62070
xref: Q9QX70
xref: CHEBI:15996
xref: P07522
xref: P20936

EGF-pEGFR-2-RasGAP
type: Complex
xref: Q9QX70
xref: P07522
xref: P20936

RhoGTP
type: Complex
xref: P61586
xref: CHEBI:15996

LEFT 0 conversion reaction 146 species 145 STOICHIOMETRY
type: Stoichiometry
physical entity: species_145
stoichiometric coefficient: 1.0

RhoGDP-pRhoGEF
type: Complex
xref: P61586
xref: Q9NZN5

LEFT 0 conversion reaction 84 species 13 STOICHIOMETRY
type: Stoichiometry
physical entity: species_13
stoichiometric coefficient: 1.0

pRhoGEF
type: Protein
xref: Q9NZN5

RhoGDP-RhoGDI
type: Complex
xref: P61586
xref: P52565

RIGHT 0 conversion reaction 69 species 55 STOICHIOMETRY
type: Stoichiometry
physical entity: species_55
stoichiometric coefficient: 1.0

species_103
type: PhysicalEntity
member physical entity: pSrc-RhoGAP
cellular location: Cell

RhoGDP
type: Complex
xref: P61586

RacGTP-RacGAP
type: Complex
xref: CHEBI:15996
xref: P63000

RacGAP
type: PhysicalEntity

species_108
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Src
cellular location: Cell

species_109
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pSrc
cellular location: Cell

LEFT 0 conversion reaction 147 species 146 STOICHIOMETRY
type: Stoichiometry
physical entity: species_146
stoichiometric coefficient: 1.0

species_10
type: PhysicalEntity
member physical entity: pShc
cellular location: Cell

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

RhoGDI-RacGDP
type: Complex
xref: CHEBI:17552
xref: P52565
xref: P63000

RhoGDI
type: Protein
xref: P52565

RacGTP
type: Complex
xref: CHEBI:15996
xref: P63000

PIP3-RacGEF-RacGDP
type: Complex
xref: CHEBI:17552
xref: Q15052
xref: P63000
xref: CHEBI:16618

RacGDP
type: Complex
xref: CHEBI:17552
xref: P63000

PIP3-RacGEF
type: Complex
xref: Q15052
xref: CHEBI:16618

LEFT 0 conversion reaction 18 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

Q15052
type: UnificationXref
id: Q15052
db: UniProt Knowledgebase

LEFT 0 conversion reaction 149 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 97 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

pRaf-pMEK
type: Complex
xref: P04049
xref: Q02750

pMEK
type: Protein
xref: Q02750

pRaf-MEK
type: Complex
xref: P04049
xref: Q02750

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

MEK
type: Protein
xref: Q02750

pRaf
type: Protein
xref: P04049

Raf-RasGTP
type: Complex
xref: P62070
xref: CHEBI:15996
xref: P04049

Raf
type: Protein
xref: P04049

EGF-pEGFR-2-Grb2-SOS-RasGDP
type: Complex
xref: P62070
xref: CHEBI:17552
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q07889

EGF-pEGFR-2-Grb2-SOS
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q07889

species_28
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

LEFT 1 conversion reaction 55 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

species_123
type: PhysicalEntity
member physical entity: pROK-EPn
cellular location: Cell

EGF-pEGFR-2-Grb2
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522

RIGHT 0 conversion reaction 54 species 52 STOICHIOMETRY
type: Stoichiometry
physical entity: species_52
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 77 species 83 STOICHIOMETRY
type: Stoichiometry
physical entity: species_83
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 203 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_129
type: PhysicalEntity
member physical entity: ppERK-pROK
cellular location: Cell

species_126
type: PhysicalEntity
member physical entity: pEPn-MPase
cellular location: Cell

GO:0016791
type: UnificationXref
id: GO:0016791
db: Gene Ontology

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_120
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-degrade
cellular location: Cell

RasGTP
type: Complex
xref: P62070
xref: CHEBI:15996

EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP
type: Complex
xref: P62070
xref: CHEBI:17552
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q07889

RasGDP
type: Complex
xref: P62070
xref: CHEBI:17552

Grb2-SOS
type: Complex
xref: P62993
xref: Q07889

species_114
type: PhysicalEntity
member physical entity: Cbl-CIN85
cellular location: Cell

EGF-pEGFR-2-pShc-Grb2-SOS
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q07889

SOS
type: Protein
xref: Q07889

EGF-pEGFR-2-pShc-Grb2
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077

Grb2
type: Protein
xref: P62993

pShc-SHP
type: Complex
xref: Q06124
xref: P98077

pShc
type: Protein
xref: P98077

species_134
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 180 species 176 STOICHIOMETRY
type: Stoichiometry
physical entity: species_176
stoichiometric coefficient: 1.0

EGF-pEGFF-2
type: Complex
xref: P07522

EGF-pEGFR-2-PI3K
type: Complex
xref: Q9QX70
xref: Q8WYR1

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

RIGHT 0 conversion reaction 138 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 151 species 150 STOICHIOMETRY
type: Stoichiometry
physical entity: species_150
stoichiometric coefficient: 1.0

species_124
type: PhysicalEntity
member physical entity: pEPn
cellular location: Cell

GO:0043548
type: UnificationXref
id: GO:0043548
db: Gene Ontology

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

PI3K
type: Protein
xref: Q8WYR1

ppERK-EGF-pEGFR-2-Grb2-SOS
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: Q07889
xref: P28482

pSOS
type: Protein
xref: Q07889

ppERK-EGF-pEGFR-2-pShc-Grb2-SOS
type: Complex
xref: Q9QX70
xref: P62993
xref: P07522
xref: P98077
xref: Q07889
xref: P28482

RasGTP-RasGAP
type: Complex
xref: P62070
xref: P20936

RasGAP
type: Protein
xref: P20936

pERK-MKP3
type: Complex
xref: Q16828
xref: P28482

ppERK-MKP3
type: Complex
xref: Q16828
xref: P28482

MKP3
type: Protein
xref: Q16828

pMEK-PP2A
type: Complex
xref: P35813
xref: Q02750

species_28
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

LEFT 0 conversion reaction 11 species 13 STOICHIOMETRY
type: Stoichiometry
physical entity: species_13
stoichiometric coefficient: 1.0

species_147
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
cellular location: Cell

species_145
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

species_107
type: PhysicalEntity
member physical entity: Src
cellular location: Cell

species_62
type: PhysicalEntity
member physical entity: pAkt-PIP3
cellular location: Cell

species_13
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2
cellular location: Cell

species_14
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

species_6
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-SHP
cellular location: Cell

ppMEK-PP2A
type: Complex
xref: P35813
xref: Q02750

PP2A
type: Protein
xref: P35813

pRaf-Pase
type: Complex
xref: P04049

Pase
type: PhysicalEntity

ppERK
type: Protein
xref: P28482

ppMEK-pERK
type: Complex
xref: Q02750
xref: P28482

Q99962
type: UnificationXref
id: Q99962
db: UniProt Knowledgebase

pERK
type: Protein
xref: P28482

ppMEK-ERK
type: Complex
xref: Q02750
xref: P28482

ERK
type: Protein
xref: P28482

ppMEK
type: Protein
xref: Q02750

RIGHT 1 conversion reaction 138 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 193 species 187 STOICHIOMETRY
type: Stoichiometry
physical entity: species_187
stoichiometric coefficient: 1.0

Q13233
type: UnificationXref
id: Q13233
db: UniProt Knowledgebase

species_152
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

species_175
type: PhysicalEntity
member physical entity: species 175
cellular location: Cell

RIGHT 1 conversion reaction 52 species 53 STOICHIOMETRY
type: Stoichiometry
physical entity: species_53
stoichiometric coefficient: 1.0

species_156
type: PhysicalEntity
member physical entity: species 156
cellular location: Cell

LEFT 0 conversion reaction 51 species 52 STOICHIOMETRY
type: Stoichiometry
physical entity: species_52
stoichiometric coefficient: 1.0

R197
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 196 species 189 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 196 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 196 species 147 STOICHIOMETRY
right: species_147
right: species_35
left: species_189

species_75
type: PhysicalEntity
member physical entity: RacGDP
cellular location: Cell

R196
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 195 species 188 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 195 species 189 STOICHIOMETRY
right: species_189
left: species_188

R199
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 198 species 143 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 198 species 95 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 198 species 82 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 198 species 190 STOICHIOMETRY
xref: GO:0005096
right: species_95
right: species_143
right: species_82
spontaneous: true
left: species_190
conversion direction: LEFT_TO_RIGHT

R198
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 197 species 171 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 197 species 190 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 197 species 95 STOICHIOMETRY
right: species_190
left: species_171
left: species_95

RIGHT 0 conversion reaction 56 species 61 STOICHIOMETRY
type: Stoichiometry
physical entity: species_61
stoichiometric coefficient: 1.0

R200
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 199 species 95 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 199 species 191 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 199 species 173 STOICHIOMETRY
right: species_191
left: species_95
left: species_173

species_142
type: PhysicalEntity
member physical entity: species 142
cellular location: Cell

RIGHT 0 conversion reaction 29 species 34 STOICHIOMETRY
type: Stoichiometry
physical entity: species_34
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 155 species 153 STOICHIOMETRY
type: Stoichiometry
physical entity: species_153
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 112 species 111 STOICHIOMETRY
type: Stoichiometry
physical entity: species_111
stoichiometric coefficient: 1.0

species_193
type: PhysicalEntity
member physical entity: species 193
cellular location: Cell

species_164
type: PhysicalEntity
member physical entity: species 164
cellular location: Cell

RIGHT 0 conversion reaction 157 species 155 STOICHIOMETRY
type: Stoichiometry
physical entity: species_155
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 165 species 161 STOICHIOMETRY
type: Stoichiometry
physical entity: species_161
stoichiometric coefficient: 1.0

species_54
type: PhysicalEntity
member physical entity: pPI3K-TP4
cellular location: Cell

species_136
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 186 species 182 STOICHIOMETRY
type: Stoichiometry
physical entity: species_182
stoichiometric coefficient: 1.0

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

RIGHT 0 conversion reaction 163 species 159 STOICHIOMETRY
type: Stoichiometry
physical entity: species_159
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 3 species 6 STOICHIOMETRY
type: Stoichiometry
physical entity: species_6
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

LEFT 1 conversion reaction 10 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 33 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_139
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
cellular location: Cell

LEFT 0 conversion reaction 140 species 140 STOICHIOMETRY
type: Stoichiometry
physical entity: species_140
stoichiometric coefficient: 1.0

species_162
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef
cellular location: Cell

LEFT 0 conversion reaction 181 species 136 STOICHIOMETRY
type: Stoichiometry
physical entity: species_136
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 17 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

species_93
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGEF
cellular location: Cell

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

species_10
type: PhysicalEntity
member physical entity: pShc
cellular location: Cell

species_153
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP
cellular location: Cell

species_45
type: PhysicalEntity
member physical entity: RasGTP-RasGAP
cellular location: Cell

GO:0004715
type: UnificationXref
id: GO:0004715
db: Gene Ontology

GO:0004716
type: UnificationXref
id: GO:0004716
db: Gene Ontology

RIGHT 0 conversion reaction 9 species 7 STOICHIOMETRY
type: Stoichiometry
physical entity: species_7
stoichiometric coefficient: 1.0

R162
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 161 species 158 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 161 species 157 STOICHIOMETRY
right: species_158
left: species_157

R161
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 160 species 157 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 160 species 156 STOICHIOMETRY
right: species_157
left: species_156

species_179
type: PhysicalEntity
member physical entity: species 179
cellular location: Cell

R160
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 159 species 151 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 159 species 31 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 159 species 156 STOICHIOMETRY
right: species_156
left: species_151
left: species_31

R153
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 152 species 151 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 152 species 150 STOICHIOMETRY
right: species_151
left: species_150

R152
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 151 species 149 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 151 species 150 STOICHIOMETRY
right: species_150
left: species_149

species_32
type: PhysicalEntity
member physical entity: ppMEK-ERK
cellular location: Cell

R155
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 154 species 133 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 154 species 152 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 154 species 19 STOICHIOMETRY
right: species_152
spontaneous: true
left: species_19
left: species_133
conversion direction: RIGHT_TO_LEFT

R154
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 153 species 151 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 153 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 153 species 148 STOICHIOMETRY
right: species_148
right: species_30
left: species_151

RIGHT 0 conversion reaction 92 species 98 STOICHIOMETRY
type: Stoichiometry
physical entity: species_98
stoichiometric coefficient: 1.0

R157
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 156 species 153 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 156 species 154 STOICHIOMETRY
right: species_154
left: species_153

R156
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 155 species 152 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 155 species 153 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 155 species 26 STOICHIOMETRY
right: species_153
left: species_26
left: species_152

R159
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 158 species 152 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 158 species 155 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 158 species 30 STOICHIOMETRY
right: species_30
right: species_152
left: species_155

species_63
type: PhysicalEntity
member physical entity: pAkt
cellular location: Cell

R158
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 157 species 154 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 157 species 155 STOICHIOMETRY
right: species_155
left: species_154

GO:0004725
type: UnificationXref
id: GO:0004725
db: Gene Ontology

species_1
type: PhysicalEntity
member physical entity: EGFR
cellular location: Cell

RIGHT 0 conversion reaction 38 species 33 STOICHIOMETRY
type: Stoichiometry
physical entity: species_33
stoichiometric coefficient: 1.0

R171
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 170 species 164 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 170 species 165 STOICHIOMETRY
right: species_165
left: species_164

R173
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 172 species 25 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 172 species 166 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 172 species 133 STOICHIOMETRY
right: species_166
left: species_25
left: species_133

LEFT 1 conversion reaction 8 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

R172
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 171 species 165 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 171 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 171 species 162 STOICHIOMETRY
right: species_30
right: species_162
left: species_165

RIGHT 0 conversion reaction 126 species 129 STOICHIOMETRY
type: Stoichiometry
physical entity: species_129
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_6
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-SHP
cellular location: Cell

LEFT 0 conversion reaction 7 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

GO:0004721
type: UnificationXref
id: GO:0004721
db: Gene Ontology

RIGHT 0 conversion reaction 85 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

RIGHT 1 conversion reaction 28 species 33 STOICHIOMETRY
type: Stoichiometry
physical entity: species_33
stoichiometric coefficient: 1.0

R164
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 163 species 155 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 163 species 31 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 163 species 159 STOICHIOMETRY
right: species_159
left: species_155
left: species_31

R163
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 162 species 151 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 162 species 158 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 162 species 35 STOICHIOMETRY
right: species_151
right: species_35
left: species_158

R166
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 165 species 161 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 165 species 160 STOICHIOMETRY
right: species_161
left: species_160

R165
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 164 species 160 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 164 species 159 STOICHIOMETRY
right: species_160
left: species_159

EGF-pEGFR-2-Grb2-SHP2-pRhoGAP
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: P07522

R168
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 167 species 25 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 167 species 162 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 167 species 132 STOICHIOMETRY
right: species_162
left: species_25
left: species_132

EGF-pEGFR-2-Grb2-SHP2-pRhoGEF
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: Q9NZN5
xref: P07522

species_13
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2
cellular location: Cell

R167
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 166 species 155 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 166 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 166 species 161 STOICHIOMETRY
right: species_155
right: species_35
left: species_161

RhoGAP
type: PhysicalEntity

R170
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 169 species 164 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 169 species 163 STOICHIOMETRY
right: species_164
left: species_163

EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP
type: Complex
xref: Q9QX70
xref: Q06124
xref: P62993
xref: P07522
xref: P98077

R169
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 168 species 162 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 168 species 163 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 168 species 26 STOICHIOMETRY
right: species_163
left: species_162
left: species_26

LEFT 0 conversion reaction 12 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

R182
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 181 species 31 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 181 species 178 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 181 species 136 STOICHIOMETRY
right: species_178
left: species_31
left: species_136

RIGHT 1 conversion reaction 192 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

R181
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 180 species 145 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 180 species 86 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 180 species 176 STOICHIOMETRY
right: species_176
spontaneous: true
left: species_86
left: species_145
conversion direction: RIGHT_TO_LEFT

R184
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 183 species 179 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 183 species 180 STOICHIOMETRY
right: species_180
left: species_179

R183
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 182 species 179 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 182 species 178 STOICHIOMETRY
right: species_179
left: species_178

RIGHT 0 conversion reaction 12 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

R175
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 174 species 167 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 174 species 168 STOICHIOMETRY
right: species_168
spontaneous: true
left: species_167
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion reaction 1 species 2 STOICHIOMETRY
type: Stoichiometry
physical entity: species_2
stoichiometric coefficient: 2.0

R174
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 173 species 166 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 173 species 26 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 173 species 167 STOICHIOMETRY
right: species_167
spontaneous: true
left: species_166
left: species_26
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 113 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 117 species 118 STOICHIOMETRY
type: Stoichiometry
physical entity: species_118
stoichiometric coefficient: 1.0

R177
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 176 species 166 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 176 species 30 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 176 species 169 STOICHIOMETRY
right: species_166
right: species_30
left: species_169

R176
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 175 species 168 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 175 species 169 STOICHIOMETRY
right: species_169
left: species_168

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

R179
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 178 species 137 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 178 species 172 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 178 species 86 STOICHIOMETRY
right: species_172
spontaneous: true
left: species_86
left: species_137
conversion direction: RIGHT_TO_LEFT

R178
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 177 species 134 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 177 species 170 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 177 species 86 STOICHIOMETRY
right: species_170
spontaneous: true
left: species_86
left: species_134
conversion direction: RIGHT_TO_LEFT

species_191
type: PhysicalEntity
member physical entity: species 191
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

R180
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 179 species 141 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 179 species 174 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 179 species 86 STOICHIOMETRY
right: species_174
spontaneous: true
left: species_141
left: species_86
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion reaction 184 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

R191
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 190 species 185 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 190 species 184 STOICHIOMETRY
right: species_185
left: species_184

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

RIGHT 0 conversion reaction 89 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

species_144
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
cellular location: Cell

R193
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 192 species 143 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 192 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 192 species 186 STOICHIOMETRY
right: species_35
right: species_143
left: species_186

GO:0004708
type: UnificationXref
id: GO:0004708
db: Gene Ontology

R192
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 191 species 185 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 191 species 186 STOICHIOMETRY
right: species_186
left: species_185

species_87
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP
cellular location: Cell

R195
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 194 species 187 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 194 species 188 STOICHIOMETRY
right: species_188
left: species_187

RIGHT 0 conversion reaction 64 species 70 STOICHIOMETRY
type: Stoichiometry
physical entity: species_70
stoichiometric coefficient: 1.0

R194
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 193 species 31 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 193 species 187 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 193 species 147 STOICHIOMETRY
right: species_187
left: species_31
left: species_147

LEFT 0 conversion reaction 83 species 88 STOICHIOMETRY
type: Stoichiometry
physical entity: species_88
stoichiometric coefficient: 1.0

species_97
type: PhysicalEntity
member physical entity: RhoGAP
cellular location: Cell

species_144
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
cellular location: Cell

species_77
type: PhysicalEntity
member physical entity: RacGTP
cellular location: Cell

LEFT 1 conversion reaction 35 species 38 STOICHIOMETRY
type: Stoichiometry
physical entity: species_38
stoichiometric coefficient: 1.0

R186
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 185 species 181 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 185 species 31 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 185 species 139 STOICHIOMETRY
right: species_181
left: species_31
left: species_139

R185
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 184 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 184 species 136 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 184 species 180 STOICHIOMETRY
right: species_136
right: species_35
left: species_180

R188
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 187 species 183 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 187 species 182 STOICHIOMETRY
right: species_183
spontaneous: true
left: species_182
conversion direction: RIGHT_TO_LEFT

species_44
type: PhysicalEntity
member physical entity: RasGAP
cellular location: Cell

R187
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 186 species 181 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 186 species 182 STOICHIOMETRY
right: species_182
left: species_181

R190
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 189 species 31 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 189 species 184 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 189 species 143 STOICHIOMETRY
right: species_184
left: species_143
left: species_31

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

R189
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 188 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 188 species 139 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 188 species 183 STOICHIOMETRY
right: species_35
right: species_139
spontaneous: true
left: species_183
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion reaction 81 species 87 STOICHIOMETRY
type: Stoichiometry
physical entity: species_87
stoichiometric coefficient: 1.0

species_29
type: PhysicalEntity
member physical entity: pRaf-pMEK
cellular location: Cell

species_139
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 96 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 155 species 152 STOICHIOMETRY
type: Stoichiometry
physical entity: species_152
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 183 species 179 STOICHIOMETRY
type: Stoichiometry
physical entity: species_179
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 48 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

species_64
type: PhysicalEntity
member physical entity: Takt
cellular location: Cell

species_80
type: PhysicalEntity
member physical entity: RacGAP
cellular location: Cell

RIGHT 0 conversion reaction 60 species 59 STOICHIOMETRY
type: Stoichiometry
physical entity: species_59
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

LEFT 0 conversion reaction 102 species 103 STOICHIOMETRY
type: Stoichiometry
physical entity: species_103
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

RIGHT 0 conversion reaction 100 species 94 STOICHIOMETRY
type: Stoichiometry
physical entity: species_94
stoichiometric coefficient: 1.0

GO:0046579
type: UnificationXref
id: GO:0046579
db: Gene Ontology

RIGHT 0 conversion reaction 204 species 144 STOICHIOMETRY
type: Stoichiometry
physical entity: species_144
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 22 species 24 STOICHIOMETRY
type: Stoichiometry
physical entity: species_24
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 58 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

GO:0046580
type: UnificationXref
id: GO:0046580
db: Gene Ontology

RIGHT 0 conversion reaction 140 species 141 STOICHIOMETRY
type: Stoichiometry
physical entity: species_141
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

RIGHT 0 conversion reaction 23 species 27 STOICHIOMETRY
type: Stoichiometry
physical entity: species_27
stoichiometric coefficient: 1.0

species_147
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 114 species 114 STOICHIOMETRY
type: Stoichiometry
physical entity: species_114
stoichiometric coefficient: 1.0

species_14
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

RIGHT 0 conversion reaction 93 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

P35813
type: UnificationXref
id: P35813
db: UniProt Knowledgebase

species_77
type: PhysicalEntity
member physical entity: RacGTP
cellular location: Cell

LEFT 0 conversion reaction 182 species 178 STOICHIOMETRY
type: Stoichiometry
physical entity: species_178
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 9 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

species_78
type: PhysicalEntity
member physical entity: RhoGDI
cellular location: Cell

RIGHT 0 conversion reaction 27 species 32 STOICHIOMETRY
type: Stoichiometry
physical entity: species_32
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 37 species 41 STOICHIOMETRY
type: Stoichiometry
physical entity: species_41
stoichiometric coefficient: 1.0

P98077
type: UnificationXref
id: P98077
db: UniProt Knowledgebase

species_94
type: PhysicalEntity
member physical entity: RhoGEF
cellular location: Cell

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

species_113
type: PhysicalEntity
member physical entity: Src-TP7
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_1
type: PhysicalEntity
member physical entity: EGFR
cellular location: Cell

LEFT 0 conversion reaction 29 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

RIGHT 0 conversion reaction 88 species 93 STOICHIOMETRY
type: Stoichiometry
physical entity: species_93
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 181 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 19 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 13 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

species_181
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcERKdef
cellular location: Cell

RIGHT 0 conversion reaction 72 species 74 STOICHIOMETRY
type: Stoichiometry
physical entity: species_74
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 77 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

R205
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 204 species 82 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 204 species 95 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 204 species 193 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 204 species 144 STOICHIOMETRY
xref: GO:0005096
right: species_82
right: species_95
right: species_144
spontaneous: true
left: species_193
conversion direction: LEFT_TO_RIGHT

R204
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 203 species 95 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 203 species 177 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 203 species 193 STOICHIOMETRY
xref: GO:0005096
right: species_193
left: species_177
left: species_95

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

Q16828
type: UnificationXref
id: Q16828
db: UniProt Knowledgebase

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

species_127
type: PhysicalEntity
member physical entity: pEPn-Mpase
cellular location: Cell

P63000
type: UnificationXref
id: P63000
db: UniProt Knowledgebase

R201
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 200 species 147 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 200 species 191 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 200 species 82 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 200 species 95 STOICHIOMETRY
xref: GO:0005096
right: species_95
right: species_82
right: species_147
spontaneous: true
left: species_191
conversion direction: LEFT_TO_RIGHT

R203
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 202 species 82 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 202 species 192 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 202 species 140 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 202 species 95 STOICHIOMETRY
xref: GO:0005096
right: species_140
right: species_82
right: species_95
spontaneous: true
left: species_192
conversion direction: LEFT_TO_RIGHT

R202
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 201 species 192 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 201 species 175 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 201 species 95 STOICHIOMETRY
right: species_192
left: species_175
left: species_95

species_155
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
cellular location: Cell

species_157
type: PhysicalEntity
member physical entity: species 157
cellular location: Cell

species_81
type: PhysicalEntity
member physical entity: RacGTP-RacGAP
cellular location: Cell

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

RIGHT 1 conversion reaction 198 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

species_138
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_96
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP
cellular location: Cell

species_108
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Src
cellular location: Cell

species_191
type: PhysicalEntity
member physical entity: species 191
cellular location: Cell

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

LEFT 0 conversion reaction 136 species 137 STOICHIOMETRY
type: Stoichiometry
physical entity: species_137
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 116 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 30 species 34 STOICHIOMETRY
type: Stoichiometry
physical entity: species_34
stoichiometric coefficient: 1.0

species_151
type: PhysicalEntity
member physical entity: species 151
cellular location: Cell

species_151
type: PhysicalEntity
member physical entity: species 151
cellular location: Cell

EGF-pEGFR-2-Shc
type: Complex
xref: Q9QX70
xref: P07522
xref: P98077

Shc
type: Protein
xref: P98077

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

EGF-pEGFR-2-pShc
type: Complex
xref: Q9QX70
xref: P07522
xref: P98077

EGF-pEGFR-2
type: Complex
xref: Q9QX70
xref: P07522

EGF-EGFR-2
type: Complex
xref: Q9QX70
xref: P07522

EGF-pEGFR-2-SHP
type: Complex
xref: Q9QX70
xref: Q06124
xref: P07522

SHP
type: Protein
xref: Q06124

EGF
type: Protein
xref: P07522

EGF-EGFR
type: Complex
xref: Q9QX70
xref: P07522

EGFR
type: Protein
xref: Q9QX70

RIGHT 0 conversion reaction 146 species 146 STOICHIOMETRY
type: Stoichiometry
physical entity: species_146
stoichiometric coefficient: 1.0

species_193
type: PhysicalEntity
member physical entity: species 193
cellular location: Cell

RIGHT 1 conversion reaction 43 species 44 STOICHIOMETRY
type: Stoichiometry
physical entity: species_44
stoichiometric coefficient: 1.0

species_121
type: PhysicalEntity
member physical entity: pShc-Grb2-SOS
cellular location: Cell

RIGHT 1 conversion reaction 143 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_102
type: PhysicalEntity
member physical entity: pSrc-RhoGEF
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

RIGHT 0 conversion reaction 66 species 72 STOICHIOMETRY
type: Stoichiometry
physical entity: species_72
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 197 species 171 STOICHIOMETRY
type: Stoichiometry
physical entity: species_171
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 123 species 125 STOICHIOMETRY
type: Stoichiometry
physical entity: species_125
stoichiometric coefficient: 1.0

species_20
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2
cellular location: Cell

RIGHT 0 conversion reaction 75 species 81 STOICHIOMETRY
type: Stoichiometry
physical entity: species_81
stoichiometric coefficient: 1.0

Q06124
type: UnificationXref
id: Q06124
db: UniProt Knowledgebase

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

RIGHT 1 conversion reaction 202 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

species_168
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbpMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 137 species 139 STOICHIOMETRY
type: Stoichiometry
physical entity: species_139
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 91 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

species_130
type: PhysicalEntity
member physical entity: MEKK1abcdef
cellular location: Cell

species_144
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
cellular location: Cell

LEFT 1 conversion reaction 128 species 130 STOICHIOMETRY
type: Stoichiometry
physical entity: species_130
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 185 species 181 STOICHIOMETRY
type: Stoichiometry
physical entity: species_181
stoichiometric coefficient: 1.0

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

RIGHT 0 conversion reaction 63 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

species_147
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
cellular location: Cell

species_118
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn
cellular location: Cell

LEFT 1 conversion reaction 12 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

species_100
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP-SHP2
cellular location: Cell

species_47
type: PhysicalEntity
member physical entity: pSOS
cellular location: Cell

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

RIGHT 0 conversion reaction 128 species 131 STOICHIOMETRY
type: Stoichiometry
physical entity: species_131
stoichiometric coefficient: 1.0

species_10
type: PhysicalEntity
member physical entity: pShc
cellular location: Cell

RIGHT 0 conversion reaction 199 species 191 STOICHIOMETRY
type: Stoichiometry
physical entity: species_191
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 86 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

species_114
type: PhysicalEntity
member physical entity: Cbl-CIN85
cellular location: Cell

RIGHT 0 conversion reaction 99 species 101 STOICHIOMETRY
type: Stoichiometry
physical entity: species_101
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 108 species 108 STOICHIOMETRY
type: Stoichiometry
physical entity: species_108
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 47 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 60 species 65 STOICHIOMETRY
type: Stoichiometry
physical entity: species_65
stoichiometric coefficient: 1.0

species_5
type: PhysicalEntity
member physical entity: SHP
cellular location: Cell

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

species_73
type: PhysicalEntity
member physical entity: RacGEF
cellular location: Cell

RIGHT 0 conversion reaction 94 species 99 STOICHIOMETRY
type: Stoichiometry
physical entity: species_99
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 172 species 166 STOICHIOMETRY
type: Stoichiometry
physical entity: species_166
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 93 species 94 STOICHIOMETRY
type: Stoichiometry
physical entity: species_94
stoichiometric coefficient: 1.0

species_178
type: PhysicalEntity
member physical entity: species 178
cellular location: Cell

species_74
type: PhysicalEntity
member physical entity: PIP3-RacGEF
cellular location: Cell

species_170
type: PhysicalEntity
member physical entity: species 170
cellular location: Cell

RIGHT 0 conversion reaction 130 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 85 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

species_72
type: PhysicalEntity
member physical entity: pPTEN-PIP3
cellular location: Cell

LEFT 1 conversion reaction 66 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 144 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

species_136
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
cellular location: Cell

species_55
type: PhysicalEntity
member physical entity: PIP2
cellular location: Cell

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

LEFT 1 conversion reaction 179 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

species_22
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-RasGDP
cellular location: Cell

RIGHT 0 conversion reaction 78 species 85 STOICHIOMETRY
type: Stoichiometry
physical entity: species_85
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 31 species 37 STOICHIOMETRY
type: Stoichiometry
physical entity: species_37
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 14 species 18 STOICHIOMETRY
type: Stoichiometry
physical entity: species_18
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 163 species 155 STOICHIOMETRY
type: Stoichiometry
physical entity: species_155
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 90 species 96 STOICHIOMETRY
type: Stoichiometry
physical entity: species_96
stoichiometric coefficient: 1.0

species_147
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 88 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 156 species 154 STOICHIOMETRY
type: Stoichiometry
physical entity: species_154
stoichiometric coefficient: 1.0

Cell
type: CellularLocationVocabulary
xref: GO:0005623

LEFT 0 conversion reaction 64 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

species_159
type: PhysicalEntity
member physical entity: species 159
cellular location: Cell

species_33
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

P62993
type: UnificationXref
id: P62993
db: UniProt Knowledgebase

RIGHT 1 conversion reaction 65 species 71 STOICHIOMETRY
type: Stoichiometry
physical entity: species_71
stoichiometric coefficient: 1.0

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

species_16
type: PhysicalEntity
member physical entity: Grb2-SOS
cellular location: Cell

LEFT 0 conversion reaction 121 species 123 STOICHIOMETRY
type: Stoichiometry
physical entity: species_123
stoichiometric coefficient: 1.0

GO:0006897
type: UnificationXref
id: GO:0006897
db: Gene Ontology

species_43
type: PhysicalEntity
member physical entity: pERK-MKP3
cellular location: Cell

http://identifiers.org/pubmed/11024454
type: PublicationXref
id: 11024454
db: PubMed

RIGHT 0 conversion reaction 132 species 135 STOICHIOMETRY
type: Stoichiometry
physical entity: species_135
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 120 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 84 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 119 species 1 STOICHIOMETRY
type: Stoichiometry
physical entity: species_1
stoichiometric coefficient: 1.0

hsa04010
type: UnificationXref
id: hsa04010
db: KEGG Pathway

RIGHT 0 conversion reaction 76 species 75 STOICHIOMETRY
type: Stoichiometry
physical entity: species_75
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 44 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 8 species 11 STOICHIOMETRY
type: Stoichiometry
physical entity: species_11
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 166 species 161 STOICHIOMETRY
type: Stoichiometry
physical entity: species_161
stoichiometric coefficient: 1.0

species_139
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
cellular location: Cell

species_23
type: PhysicalEntity
member physical entity: Raf
cellular location: Cell

species_38
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

species_94
type: PhysicalEntity
member physical entity: RhoGEF
cellular location: Cell

RIGHT 0 conversion reaction 184 species 136 STOICHIOMETRY
type: Stoichiometry
physical entity: species_136
stoichiometric coefficient: 1.0

species_136
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abppMEKcdef
cellular location: Cell

species_94
type: PhysicalEntity
member physical entity: RhoGEF
cellular location: Cell

RIGHT 0 conversion reaction 39 species 43 STOICHIOMETRY
type: Stoichiometry
physical entity: species_43
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 64 species 69 STOICHIOMETRY
type: Stoichiometry
physical entity: species_69
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 144 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 68 species 69 STOICHIOMETRY
type: Stoichiometry
physical entity: species_69
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/16687399
type: PublicationXref
id: 16687399
db: PubMed

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

LEFT 1 conversion reaction 81 species 44 STOICHIOMETRY
type: Stoichiometry
physical entity: species_44
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 104 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 185 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 135 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 96 species 100 STOICHIOMETRY
type: Stoichiometry
physical entity: species_100
stoichiometric coefficient: 1.0

species_20
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2
cellular location: Cell

species_85
type: PhysicalEntity
member physical entity: RhoGDP-pRhoGEF
cellular location: Cell

species_22
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-RasGDP
cellular location: Cell

LEFT 0 conversion reaction 125 species 128 STOICHIOMETRY
type: Stoichiometry
physical entity: species_128
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 82 species 88 STOICHIOMETRY
type: Stoichiometry
physical entity: species_88
stoichiometric coefficient: 1.0

species_49
type: PhysicalEntity
member physical entity: PI3K
cellular location: Cell

LEFT 0 conversion reaction 21 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

species_143
type: PhysicalEntity
member physical entity: species 143
cellular location: Cell

species_54
type: PhysicalEntity
member physical entity: pPI3K-TP4
cellular location: Cell

species_49
type: PhysicalEntity
member physical entity: PI3K
cellular location: Cell

RIGHT 1 conversion reaction 62 species 62 STOICHIOMETRY
type: Stoichiometry
physical entity: species_62
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 170 species 165 STOICHIOMETRY
type: Stoichiometry
physical entity: species_165
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 123 species 127 STOICHIOMETRY
type: Stoichiometry
physical entity: species_127
stoichiometric coefficient: 1.0

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

GO:0004674
type: UnificationXref
id: GO:0004674
db: Gene Ontology

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

GO:0005525
type: UnificationXref
id: GO:0005525
db: Gene Ontology

species_187
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbppMEKcERKdef
cellular location: Cell

species_186
type: PhysicalEntity
member physical entity: species 186
cellular location: Cell

species_189
type: PhysicalEntity
member physical entity: species 189
cellular location: Cell

species_62
type: PhysicalEntity
member physical entity: pAkt-PIP3
cellular location: Cell

species_80
type: PhysicalEntity
member physical entity: RacGAP
cellular location: Cell

LEFT 0 conversion reaction 194 species 187 STOICHIOMETRY
type: Stoichiometry
physical entity: species_187
stoichiometric coefficient: 1.0

species_37
type: PhysicalEntity
member physical entity: pRaf-Pase
cellular location: Cell

RIGHT 0 conversion reaction 198 species 143 STOICHIOMETRY
type: Stoichiometry
physical entity: species_143
stoichiometric coefficient: 1.0

species_184
type: PhysicalEntity
member physical entity: species 184
cellular location: Cell

species_179
type: PhysicalEntity
member physical entity: species 179
cellular location: Cell

LEFT 1 conversion reaction 21 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

species_65
type: PhysicalEntity
member physical entity: pAkt-PIP3-Takt
cellular location: Cell

RIGHT 1 conversion reaction 45 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 58 species 62 STOICHIOMETRY
type: Stoichiometry
physical entity: species_62
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 5 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_72
type: PhysicalEntity
member physical entity: pPTEN-PIP3
cellular location: Cell

RIGHT 0 conversion reaction 79 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

GO:0005515
type: UnificationXref
id: GO:0005515
db: Gene Ontology

species_44
type: PhysicalEntity
member physical entity: RasGAP
cellular location: Cell

species_182
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef
cellular location: Cell

LEFT 0 conversion reaction 192 species 186 STOICHIOMETRY
type: Stoichiometry
physical entity: species_186
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 118 species 114 STOICHIOMETRY
type: Stoichiometry
physical entity: species_114
stoichiometric coefficient: 1.0

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

RIGHT 0 conversion reaction 179 species 174 STOICHIOMETRY
type: Stoichiometry
physical entity: species_174
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 176 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 99 species 102 STOICHIOMETRY
type: Stoichiometry
physical entity: species_102
stoichiometric coefficient: 1.0

species_153
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdefRasGTP
cellular location: Cell

species_9
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc
cellular location: Cell

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

RIGHT 0 conversion reaction 188 species 139 STOICHIOMETRY
type: Stoichiometry
physical entity: species_139
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 201 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_44
type: PhysicalEntity
member physical entity: RasGAP
cellular location: Cell

LEFT 0 conversion reaction 127 species 129 STOICHIOMETRY
type: Stoichiometry
physical entity: species_129
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 18 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

species_148
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

R7
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 6 species 9 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 6 species 8 STOICHIOMETRY
xref: GO:0004716
xref: http://identifiers.org/ec-code/2.7.11.1
xref: GO:0006468
right: species_9
left: species_8

R6
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 5 species 7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 5 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 5 species 8 STOICHIOMETRY
xref: GO:0051425
xref: GO:0042169
right: species_8
left: species_7
left: species_4

R9
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 8 species 10 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 8 species 5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 8 species 11 STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
right: species_11
spontaneous: true
left: species_5
left: species_10
conversion direction: LEFT_TO_RIGHT

R8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 7 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 7 species 10 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 7 species 9 STOICHIOMETRY
xref: GO:0043241
right: species_10
right: species_4
left: species_9

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

R10
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 9 species 5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 9 species 11 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 9 species 7 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_5
right: species_7
spontaneous: true
left: species_11
conversion direction: RIGHT_TO_LEFT

R1
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 0 species 2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0 species 0 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 0 species 1 STOICHIOMETRY
xref: GO:0005154
right: species_2
spontaneous: true
left: species_1
left: species_0
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion reaction 152 species 150 STOICHIOMETRY
type: Stoichiometry
physical entity: species_150
stoichiometric coefficient: 1.0

R3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 2 species 3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 2 species 4 STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.1
xref: GO:0006468
right: species_4
left: species_3

R2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 1 species 2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 1 species 3 STOICHIOMETRY
xref: GO:0046983
right: species_3
left: species_2

RIGHT 0 conversion reaction 136 species 138 STOICHIOMETRY
type: Stoichiometry
physical entity: species_138
stoichiometric coefficient: 1.0

R5
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 4 species 6 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 4 species 5 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 4 species 3 STOICHIOMETRY
xref: GO:0006470
xref: GO:0004725
xref: http://identifiers.org/ec-code/3.1.3.16
right: species_5
right: species_3
left: species_6

R4
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 3 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 3 species 6 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 3 species 5 STOICHIOMETRY
xref: GO:0005515
right: species_6
left: species_5
left: species_4

MODEL7802538336
type: UnificationXref
id: MODEL7802538336
db: BioModels Database

species_33
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

RIGHT 0 conversion reaction 6 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

species_48
type: PhysicalEntity
member physical entity: ppERK-EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

LEFT 1 conversion reaction 129 species 131 STOICHIOMETRY
type: Stoichiometry
physical entity: species_131
stoichiometric coefficient: 1.0

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

LEFT 0 conversion reaction 97 species 100 STOICHIOMETRY
type: Stoichiometry
physical entity: species_100
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

RIGHT 0 conversion reaction 97 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 50 species 51 STOICHIOMETRY
type: Stoichiometry
physical entity: species_51
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 168 species 162 STOICHIOMETRY
type: Stoichiometry
physical entity: species_162
stoichiometric coefficient: 1.0

GO:0046983
type: UnificationXref
id: GO:0046983
db: Gene Ontology

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

species_143
type: PhysicalEntity
member physical entity: species 143
cellular location: Cell

LEFT 0 conversion reaction 85 species 20 STOICHIOMETRY
type: Stoichiometry
physical entity: species_20
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

RIGHT 1 conversion reaction 95 species 97 STOICHIOMETRY
type: Stoichiometry
physical entity: species_97
stoichiometric coefficient: 1.0

species_155
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
cellular location: Cell

LEFT 0 conversion reaction 196 species 189 STOICHIOMETRY
type: Stoichiometry
physical entity: species_189
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 129 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

BIOMD0000000019
type: UnificationXref
id: BIOMD0000000019
db: BioModels Database

species_146
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef
cellular location: Cell

LEFT 0 conversion reaction 126 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_17
type: PhysicalEntity
member physical entity: RasGDP
cellular location: Cell

species_42
type: PhysicalEntity
member physical entity: ppERK-MKP3
cellular location: Cell

species_190
type: PhysicalEntity
member physical entity: species 190
cellular location: Cell

LEFT 1 conversion reaction 159 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 59 species 62 STOICHIOMETRY
type: Stoichiometry
physical entity: species_62
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 62 species 66 STOICHIOMETRY
type: Stoichiometry
physical entity: species_66
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

LEFT 1 conversion reaction 31 species 36 STOICHIOMETRY
type: Stoichiometry
physical entity: species_36
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 73 species 75 STOICHIOMETRY
type: Stoichiometry
physical entity: species_75
stoichiometric coefficient: 1.0

species_16
type: PhysicalEntity
member physical entity: Grb2-SOS
cellular location: Cell

LEFT 1 conversion reaction 149 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

GO:0042169
type: UnificationXref
id: GO:0042169
db: Gene Ontology

RIGHT 0 conversion reaction 83 species 89 STOICHIOMETRY
type: Stoichiometry
physical entity: species_89
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 23 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

Ung2008 EGFR Endocytosis
type: Pathway
pathway component: R117
pathway component: R116
pathway component: R119
pathway component: R118
pathway component: R120
pathway component: R111
pathway component: R113
pathway component: R112
pathway component: R115
pathway component: R114
pathway component: R128
pathway component: R127
pathway component: R130
pathway component: R129
pathway component: R122
pathway component: R121
pathway component: R124
pathway component: R123
pathway component: R126
pathway component: R125
pathway component: R139
pathway component: R138
pathway component: R140
pathway component: R131
pathway component: R133
pathway component: R132
pathway component: R135
pathway component: R134
pathway component: R137
pathway component: R136
pathway component: R151
pathway component: R150
pathway component: R149
pathway component: R142
pathway component: R141
pathway component: R144
pathway component: R143
pathway component: R146
pathway component: R145
pathway component: R148
pathway component: R147
pathway component: R98
pathway component: R97
pathway component: R96
pathway component: R95
pathway component: R100
pathway component: R99
pathway component: R94
pathway component: R93
pathway component: R92
pathway component: R91
pathway component: R205
pathway component: R204
pathway component: R201
pathway component: R203
pathway component: R202
pathway component: R76
pathway component: R75
pathway component: R74
pathway component: R73
pathway component: R80
pathway component: R79
pathway component: R78
pathway component: R77
pathway component: R72
pathway component: R71
pathway component: R87
pathway component: R106
pathway component: R86
pathway component: R105
pathway component: R85
pathway component: R108
pathway component: R84
pathway component: R107
pathway component: R110
pathway component: R90
pathway component: R109
pathway component: R89
pathway component: R88

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

species_134
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abMEKcdef
cellular location: Cell

CHEBI:15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

species_8
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Shc
cellular location: Cell

RIGHT 0 conversion reaction 98 species 102 STOICHIOMETRY
type: Stoichiometry
physical entity: species_102
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 54 species 56 STOICHIOMETRY
type: Stoichiometry
physical entity: species_56
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 42 species 45 STOICHIOMETRY
type: Stoichiometry
physical entity: species_45
stoichiometric coefficient: 1.0

BIOMD0000000048
type: UnificationXref
id: BIOMD0000000048
db: BioModels Database

LEFT 0 conversion reaction 105 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

species_9
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc
cellular location: Cell

RIGHT 2 conversion reaction 204 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_164
type: PhysicalEntity
member physical entity: species 164
cellular location: Cell

RIGHT 0 conversion reaction 112 species 107 STOICHIOMETRY
type: Stoichiometry
physical entity: species_107
stoichiometric coefficient: 1.0

species_5
type: PhysicalEntity
member physical entity: SHP
cellular location: Cell

species_167
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbMEKcdef
cellular location: Cell

species_137
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 33 species 39 STOICHIOMETRY
type: Stoichiometry
physical entity: species_39
stoichiometric coefficient: 1.0

species_137
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
cellular location: Cell

species_74
type: PhysicalEntity
member physical entity: PIP3-RacGEF
cellular location: Cell

BIOMD0000000049
type: UnificationXref
id: BIOMD0000000049
db: BioModels Database

LEFT 0 conversion reaction 17 species 20 STOICHIOMETRY
type: Stoichiometry
physical entity: species_20
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 196 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 9 species 11 STOICHIOMETRY
type: Stoichiometry
physical entity: species_11
stoichiometric coefficient: 1.0

hsa04070
type: UnificationXref
id: hsa04070
db: KEGG Pathway

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

RIGHT 0 conversion reaction 139 species 140 STOICHIOMETRY
type: Stoichiometry
physical entity: species_140
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_70
type: PhysicalEntity
member physical entity: pROK-PTEN
cellular location: Cell

RIGHT 0 conversion reaction 142 species 143 STOICHIOMETRY
type: Stoichiometry
physical entity: species_143
stoichiometric coefficient: 1.0

RIGHT 4 conversion reaction 45 species 47 STOICHIOMETRY
type: Stoichiometry
physical entity: species_47
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 111 species 113 STOICHIOMETRY
type: Stoichiometry
physical entity: species_113
stoichiometric coefficient: 1.0

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

RIGHT 0 conversion reaction 153 species 148 STOICHIOMETRY
type: Stoichiometry
physical entity: species_148
stoichiometric coefficient: 1.0

species_52
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

RIGHT 0 conversion reaction 87 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 196 species 147 STOICHIOMETRY
type: Stoichiometry
physical entity: species_147
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.12.2
type: UnificationXref
id: 2.7.12.2
db: Enzyme Nomenclature

species_143
type: PhysicalEntity
member physical entity: species 143
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

species_56
type: PhysicalEntity
member physical entity: pPI3K-PIP2
cellular location: Cell

P62070
type: UnificationXref
id: P62070
db: UniProt Knowledgebase

LEFT 0 conversion reaction 173 species 166 STOICHIOMETRY
type: Stoichiometry
physical entity: species_166
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 156 species 153 STOICHIOMETRY
type: Stoichiometry
physical entity: species_153
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 48 species 47 STOICHIOMETRY
type: Stoichiometry
physical entity: species_47
stoichiometric coefficient: 1.0

Q02750
type: UnificationXref
id: Q02750
db: UniProt Knowledgebase

species_33
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

RIGHT 0 conversion reaction 202 species 140 STOICHIOMETRY
type: Stoichiometry
physical entity: species_140
stoichiometric coefficient: 1.0

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

http://identifiers.org/taxonomy/2759
type: UnificationXref
id: 2759
db: Taxonomy

species_143
type: PhysicalEntity
member physical entity: species 143
cellular location: Cell

LEFT 0 conversion reaction 95 species 99 STOICHIOMETRY
type: Stoichiometry
physical entity: species_99
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 107 species 108 STOICHIOMETRY
type: Stoichiometry
physical entity: species_108
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 0 species 0 STOICHIOMETRY
type: Stoichiometry
physical entity: species_0
stoichiometric coefficient: 1.0

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_52
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

species_39
type: PhysicalEntity
member physical entity: ppMEK-PP2A
cellular location: Cell

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

LEFT 0 conversion reaction 55 species 58 STOICHIOMETRY
type: Stoichiometry
physical entity: species_58
stoichiometric coefficient: 1.0

species_44
type: PhysicalEntity
member physical entity: RasGAP
cellular location: Cell

RIGHT 1 conversion reaction 26 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

LEFT 0 conversion reaction 137 species 138 STOICHIOMETRY
type: Stoichiometry
physical entity: species_138
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

species_107
type: PhysicalEntity
member physical entity: Src
cellular location: Cell

species_178
type: PhysicalEntity
member physical entity: species 178
cellular location: Cell

RIGHT 0 conversion reaction 25 species 29 STOICHIOMETRY
type: Stoichiometry
physical entity: species_29
stoichiometric coefficient: 1.0

species_71
type: PhysicalEntity
member physical entity: pPTEN
cellular location: Cell

species_119
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn
cellular location: Cell

species_62
type: PhysicalEntity
member physical entity: pAkt-PIP3
cellular location: Cell

LEFT 1 conversion reaction 82 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_123
type: PhysicalEntity
member physical entity: pROK-EPn
cellular location: Cell

species_184
type: PhysicalEntity
member physical entity: species 184
cellular location: Cell

LEFT 0 conversion reaction 20 species 22 STOICHIOMETRY
type: Stoichiometry
physical entity: species_22
stoichiometric coefficient: 1.0

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

species_116
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85
cellular location: Cell

RIGHT 0 conversion reaction 187 species 183 STOICHIOMETRY
type: Stoichiometry
physical entity: species_183
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 45 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 46 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 4 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

LEFT 0 conversion reaction 187 species 182 STOICHIOMETRY
type: Stoichiometry
physical entity: species_182
stoichiometric coefficient: 1.0

species_183
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcppERKdef
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

species_166
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbcdef
cellular location: Cell

species_129
type: PhysicalEntity
member physical entity: ppERK-pROK
cellular location: Cell

LEFT 0 conversion reaction 69 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 74 species 75 STOICHIOMETRY
type: Stoichiometry
physical entity: species_75
stoichiometric coefficient: 1.0

species_172
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdRhoGTPef
cellular location: Cell

RIGHT 1 conversion reaction 60 species 64 STOICHIOMETRY
type: Stoichiometry
physical entity: species_64
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 5 species 7 STOICHIOMETRY
type: Stoichiometry
physical entity: species_7
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 192 species 143 STOICHIOMETRY
type: Stoichiometry
physical entity: species_143
stoichiometric coefficient: 1.0

species_98
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2-pRhoGEF
cellular location: Cell

LEFT 0 conversion reaction 167 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 191 species 186 STOICHIOMETRY
type: Stoichiometry
physical entity: species_186
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 86 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 32 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 27 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

species_38
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

RIGHT 1 conversion reaction 158 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 134 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 189 species 184 STOICHIOMETRY
type: Stoichiometry
physical entity: species_184
stoichiometric coefficient: 1.0

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

species_131
type: PhysicalEntity
member physical entity: Grb2-MEKK1abcdef
cellular location: Cell

O15530
type: UnificationXref
id: O15530
db: UniProt Knowledgebase

RIGHT 1 conversion reaction 57 species 60 STOICHIOMETRY
type: Stoichiometry
physical entity: species_60
stoichiometric coefficient: 1.0

species_177
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbcdRhoGTPef
cellular location: Cell

species_150
type: PhysicalEntity
member physical entity: species 150
cellular location: Cell

LEFT 0 conversion reaction 14 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 148 species 144 STOICHIOMETRY
type: Stoichiometry
physical entity: species_144
stoichiometric coefficient: 1.0

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_155
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
cellular location: Cell

LEFT 0 conversion reaction 52 species 54 STOICHIOMETRY
type: Stoichiometry
physical entity: species_54
stoichiometric coefficient: 1.0

species_76
type: PhysicalEntity
member physical entity: PIP3-RacGEF-RacGDP
cellular location: Cell

species_154
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abpMEKcdefRasGTP
cellular location: Cell

LEFT 1 conversion reaction 46 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 158 species 152 STOICHIOMETRY
type: Stoichiometry
physical entity: species_152
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 66 species 71 STOICHIOMETRY
type: Stoichiometry
physical entity: species_71
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 125 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_105
type: PhysicalEntity
member physical entity: ROK
cellular location: Cell

RIGHT 0 conversion reaction 174 species 168 STOICHIOMETRY
type: Stoichiometry
physical entity: species_168
stoichiometric coefficient: 1.0

species_163
type: PhysicalEntity
member physical entity: species 163
cellular location: Cell

species_78
type: PhysicalEntity
member physical entity: RhoGDI
cellular location: Cell

species_98
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2-pRhoGEF
cellular location: Cell

LEFT 1 conversion reaction 103 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 11 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 16 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 107 species 107 STOICHIOMETRY
type: Stoichiometry
physical entity: species_107
stoichiometric coefficient: 1.0

species_138
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abpMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 0 species 1 STOICHIOMETRY
type: Stoichiometry
physical entity: species_1
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 34 species 28 STOICHIOMETRY
type: Stoichiometry
physical entity: species_28
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 154 species 152 STOICHIOMETRY
type: Stoichiometry
physical entity: species_152
stoichiometric coefficient: 1.0

GO:0005154
type: UnificationXref
id: GO:0005154
db: Gene Ontology

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

RIGHT 2 conversion reaction 198 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 151 species 149 STOICHIOMETRY
type: Stoichiometry
physical entity: species_149
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 118 species 120 STOICHIOMETRY
type: Stoichiometry
physical entity: species_120
stoichiometric coefficient: 1.0

species_0
type: PhysicalEntity
member physical entity: EGF
cellular location: Cell

GO:0017124
type: UnificationXref
id: GO:0017124
db: Gene Ontology

P31749
type: UnificationXref
id: P31749
db: UniProt Knowledgebase

species_141
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 154 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 101 species 103 STOICHIOMETRY
type: Stoichiometry
physical entity: species_103
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 135 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 49 species 49 STOICHIOMETRY
type: Stoichiometry
physical entity: species_49
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 40 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 155 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

species_165
type: PhysicalEntity
member physical entity: species 165
cellular location: Cell

species_131
type: PhysicalEntity
member physical entity: Grb2-MEKK1abcdef
cellular location: Cell

LEFT 0 conversion reaction 190 species 184 STOICHIOMETRY
type: Stoichiometry
physical entity: species_184
stoichiometric coefficient: 1.0

species_60
type: PhysicalEntity
member physical entity: PDK1
cellular location: Cell

RIGHT 1 conversion reaction 54 species 57 STOICHIOMETRY
type: Stoichiometry
physical entity: species_57
stoichiometric coefficient: 1.0

species_7
type: PhysicalEntity
member physical entity: Shc
cellular location: Cell

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

LEFT 0 conversion reaction 171 species 165 STOICHIOMETRY
type: Stoichiometry
physical entity: species_165
stoichiometric coefficient: 1.0

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

LEFT 0 conversion reaction 65 species 70 STOICHIOMETRY
type: Stoichiometry
physical entity: species_70
stoichiometric coefficient: 1.0

species_157
type: PhysicalEntity
member physical entity: species 157
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

GO:0051425
type: UnificationXref
id: GO:0051425
db: Gene Ontology

species_46
type: PhysicalEntity
member physical entity: ppERK-EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

P61586
type: UnificationXref
id: P61586
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 182 species 179 STOICHIOMETRY
type: Stoichiometry
physical entity: species_179
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 44 species 46 STOICHIOMETRY
type: Stoichiometry
physical entity: species_46
stoichiometric coefficient: 1.0

Q96B97
type: UnificationXref
id: Q96B97
db: UniProt Knowledgebase

species_7
type: PhysicalEntity
member physical entity: Shc
cellular location: Cell

species_144
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbcdef
cellular location: Cell

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

LEFT 0 conversion reaction 116 species 116 STOICHIOMETRY
type: Stoichiometry
physical entity: species_116
stoichiometric coefficient: 1.0

GO:0006461
type: UnificationXref
id: GO:0006461
db: Gene Ontology

RIGHT 0 conversion reaction 1 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 134 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

RIGHT 1 conversion reaction 102 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_27
type: PhysicalEntity
member physical entity: pRaf-MEK
cellular location: Cell

RIGHT 0 conversion reaction 103 species 104 STOICHIOMETRY
type: Stoichiometry
physical entity: species_104
stoichiometric coefficient: 1.0

species_111
type: PhysicalEntity
member physical entity: TP7
cellular location: Cell

LEFT 0 conversion reaction 130 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

GO:0006468
type: UnificationXref
id: GO:0006468
db: Gene Ontology

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

GO:0006470
type: UnificationXref
id: GO:0006470
db: Gene Ontology

LEFT 0 conversion reaction 159 species 151 STOICHIOMETRY
type: Stoichiometry
physical entity: species_151
stoichiometric coefficient: 1.0

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

species_185
type: PhysicalEntity
member physical entity: species 185
cellular location: Cell

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

RIGHT 0 conversion reaction 144 species 144 STOICHIOMETRY
type: Stoichiometry
physical entity: species_144
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 178 species 137 STOICHIOMETRY
type: Stoichiometry
physical entity: species_137
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 49 species 50 STOICHIOMETRY
type: Stoichiometry
physical entity: species_50
stoichiometric coefficient: 1.0

species_139
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdef
cellular location: Cell

RIGHT 1 conversion reaction 89 species 94 STOICHIOMETRY
type: Stoichiometry
physical entity: species_94
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 161 species 157 STOICHIOMETRY
type: Stoichiometry
physical entity: species_157
stoichiometric coefficient: 1.0

species_76
type: PhysicalEntity
member physical entity: PIP3-RacGEF-RacGDP
cellular location: Cell

species_162
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1apRafbcdef
cellular location: Cell

LEFT 1 conversion reaction 44 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 94 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 47 species 48 STOICHIOMETRY
type: Stoichiometry
physical entity: species_48
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 202 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 124 species 94 STOICHIOMETRY
type: Stoichiometry
physical entity: species_94
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 42 species 44 STOICHIOMETRY
type: Stoichiometry
physical entity: species_44
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 118 species 119 STOICHIOMETRY
type: Stoichiometry
physical entity: species_119
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 110 species 111 STOICHIOMETRY
type: Stoichiometry
physical entity: species_111
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 13 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 19 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

LEFT 0 conversion reaction 106 species 106 STOICHIOMETRY
type: Stoichiometry
physical entity: species_106
stoichiometric coefficient: 1.0

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

species_34
type: PhysicalEntity
member physical entity: ppMEK-pERK
cellular location: Cell

species_75
type: PhysicalEntity
member physical entity: RacGDP
cellular location: Cell

LEFT 0 conversion reaction 200 species 191 STOICHIOMETRY
type: Stoichiometry
physical entity: species_191
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 150 species 149 STOICHIOMETRY
type: Stoichiometry
physical entity: species_149
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 118 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 152 species 151 STOICHIOMETRY
type: Stoichiometry
physical entity: species_151
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 20 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 70 species 73 STOICHIOMETRY
type: Stoichiometry
physical entity: species_73
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 179 species 141 STOICHIOMETRY
type: Stoichiometry
physical entity: species_141
stoichiometric coefficient: 1.0

species_43
type: PhysicalEntity
member physical entity: pERK-MKP3
cellular location: Cell

RIGHT 1 conversion reaction 127 species 105 STOICHIOMETRY
type: Stoichiometry
physical entity: species_105
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 126 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

species_2
type: PhysicalEntity
member physical entity: EGF-EGFR
cellular location: Cell

species_52
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

species_48
type: PhysicalEntity
member physical entity: ppERK-EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

RIGHT 0 conversion reaction 16 species 20 STOICHIOMETRY
type: Stoichiometry
physical entity: species_20
stoichiometric coefficient: 1.0

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

RIGHT 0 conversion reaction 168 species 163 STOICHIOMETRY
type: Stoichiometry
physical entity: species_163
stoichiometric coefficient: 1.0

species_110
type: PhysicalEntity
member physical entity: EGF-pEGRF-2
cellular location: Cell

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_46
type: PhysicalEntity
member physical entity: ppERK-EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

species_104
type: PhysicalEntity
member physical entity: pRhoGAP-RhoGTP
cellular location: Cell

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

RIGHT 0 conversion reaction 181 species 178 STOICHIOMETRY
type: Stoichiometry
physical entity: species_178
stoichiometric coefficient: 1.0

species_65
type: PhysicalEntity
member physical entity: pAkt-PIP3-Takt
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_20
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2
cellular location: Cell

LEFT 0 conversion reaction 56 species 59 STOICHIOMETRY
type: Stoichiometry
physical entity: species_59
stoichiometric coefficient: 1.0

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

RIGHT 0 conversion reaction 65 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 39 species 41 STOICHIOMETRY
type: Stoichiometry
physical entity: species_41
stoichiometric coefficient: 1.0

species_106
type: PhysicalEntity
member physical entity: RhoGTP-ROK
cellular location: Cell

LEFT 0 conversion reaction 68 species 71 STOICHIOMETRY
type: Stoichiometry
physical entity: species_71
stoichiometric coefficient: 1.0

species_116
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85
cellular location: Cell

RIGHT 0 conversion reaction 167 species 162 STOICHIOMETRY
type: Stoichiometry
physical entity: species_162
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 91 species 96 STOICHIOMETRY
type: Stoichiometry
physical entity: species_96
stoichiometric coefficient: 1.0

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

species_131
type: PhysicalEntity
member physical entity: Grb2-MEKK1abcdef
cellular location: Cell

LEFT 0 conversion reaction 201 species 175 STOICHIOMETRY
type: Stoichiometry
physical entity: species_175
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 15 species 18 STOICHIOMETRY
type: Stoichiometry
physical entity: species_18
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 23 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

LEFT 1 conversion reaction 178 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 189 species 143 STOICHIOMETRY
type: Stoichiometry
physical entity: species_143
stoichiometric coefficient: 1.0

species_119
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS-Cbl-CIN85-EPn
cellular location: Cell

species_128
type: PhysicalEntity
member physical entity: Ras-GTP-RhoGEF
cellular location: Cell

LEFT 1 conversion reaction 193 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

species_18
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-RasGDP
cellular location: Cell

LEFT 0 conversion reaction 119 species 122 STOICHIOMETRY
type: Stoichiometry
physical entity: species_122
stoichiometric coefficient: 1.0

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

species_82
type: PhysicalEntity
member physical entity: RhoGDP
cellular location: Cell

species_42
type: PhysicalEntity
member physical entity: ppERK-MKP3
cellular location: Cell

LEFT 0 conversion reaction 148 species 147 STOICHIOMETRY
type: Stoichiometry
physical entity: species_147
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 84 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 111 species 112 STOICHIOMETRY
type: Stoichiometry
physical entity: species_112
stoichiometric coefficient: 1.0

species_125
type: PhysicalEntity
member physical entity: MPase
cellular location: Cell

LEFT 0 conversion reaction 63 species 67 STOICHIOMETRY
type: Stoichiometry
physical entity: species_67
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 148 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

RIGHT 0 conversion reaction 43 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

RIGHT 3 conversion reaction 45 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 76 species 80 STOICHIOMETRY
type: Stoichiometry
physical entity: species_80
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 112 species 113 STOICHIOMETRY
type: Stoichiometry
physical entity: species_113
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 2 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

GO:0000185
type: UnificationXref
id: GO:0000185
db: Gene Ontology

GO:0000187
type: UnificationXref
id: GO:0000187
db: Gene Ontology

RIGHT 1 conversion reaction 83 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

species_61
type: PhysicalEntity
member physical entity: Akt-PIP3-PDK1
cellular location: Cell

LEFT 0 conversion reaction 8 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 172 species 133 STOICHIOMETRY
type: Stoichiometry
physical entity: species_133
stoichiometric coefficient: 1.0

species_112
type: PhysicalEntity
member physical entity: pSrc-TP7
cellular location: Cell

species_148
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

species_150
type: PhysicalEntity
member physical entity: species 150
cellular location: Cell

species_5
type: PhysicalEntity
member physical entity: SHP
cellular location: Cell

RIGHT 0 conversion reaction 36 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 170 species 164 STOICHIOMETRY
type: Stoichiometry
physical entity: species_164
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 106 species 68 STOICHIOMETRY
type: Stoichiometry
physical entity: species_68
stoichiometric coefficient: 1.0

species_71
type: PhysicalEntity
member physical entity: pPTEN
cellular location: Cell

LEFT 0 conversion reaction 88 species 91 STOICHIOMETRY
type: Stoichiometry
physical entity: species_91
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 188 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_149
type: PhysicalEntity
member physical entity: species 149
cellular location: Cell

species_192
type: PhysicalEntity
member physical entity: species 192
cellular location: Cell

species_141
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbMEKcdef
cellular location: Cell

LEFT 1 conversion reaction 197 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

species_163
type: PhysicalEntity
member physical entity: species 163
cellular location: Cell

species_33
type: PhysicalEntity
member physical entity: pERK
cellular location: Cell

species_101
type: PhysicalEntity
member physical entity: pSrc
cellular location: Cell

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

LEFT 0 conversion reaction 142 species 142 STOICHIOMETRY
type: Stoichiometry
physical entity: species_142
stoichiometric coefficient: 1.0

species_100
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP-SHP2
cellular location: Cell

LEFT 0 conversion reaction 89 species 93 STOICHIOMETRY
type: Stoichiometry
physical entity: species_93
stoichiometric coefficient: 1.0

RIGHT 1 conversion reaction 204 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

species_52
type: PhysicalEntity
member physical entity: pPI3K
cellular location: Cell

species_41
type: PhysicalEntity
member physical entity: MKP3
cellular location: Cell

species_39
type: PhysicalEntity
member physical entity: ppMEK-PP2A
cellular location: Cell

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

LEFT 1 conversion reaction 101 species 97 STOICHIOMETRY
type: Stoichiometry
physical entity: species_97
stoichiometric coefficient: 1.0

species_133
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdef
cellular location: Cell

LEFT 0 conversion reaction 132 species 134 STOICHIOMETRY
type: Stoichiometry
physical entity: species_134
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 124 species 128 STOICHIOMETRY
type: Stoichiometry
physical entity: species_128
stoichiometric coefficient: 1.0

species_166
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbcdef
cellular location: Cell

RIGHT 0 conversion reaction 195 species 189 STOICHIOMETRY
type: Stoichiometry
physical entity: species_189
stoichiometric coefficient: 1.0

Q13464
type: UnificationXref
id: Q13464
db: UniProt Knowledgebase

species_51
type: PhysicalEntity
member physical entity: EGF-pEGFF-2
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

species_59
type: PhysicalEntity
member physical entity: Akt-PIP3
cellular location: Cell

RIGHT 1 conversion reaction 36 species 38 STOICHIOMETRY
type: Stoichiometry
physical entity: species_38
stoichiometric coefficient: 1.0

RIGHT 2 conversion reaction 117 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

species_152
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abcdefRasGTP
cellular location: Cell

species_140
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
cellular location: Cell

species_38
type: PhysicalEntity
member physical entity: PP2A
cellular location: Cell

species_96
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2-pRhoGAP
cellular location: Cell

LEFT 0 conversion reaction 24 species 27 STOICHIOMETRY
type: Stoichiometry
physical entity: species_27
stoichiometric coefficient: 1.0

species_115
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85
cellular location: Cell

species_102
type: PhysicalEntity
member physical entity: pSrc-RhoGEF
cellular location: Cell

LEFT 0 conversion reaction 158 species 155 STOICHIOMETRY
type: Stoichiometry
physical entity: species_155
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

LEFT 1 conversion reaction 173 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

species_182
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcpERKdef
cellular location: Cell

http://identifiers.org/ec-code/2.7.10.2
type: UnificationXref
id: 2.7.10.2
db: Enzyme Nomenclature

http://identifiers.org/ec-code/2.7.10.1
type: UnificationXref
id: 2.7.10.1
db: Enzyme Nomenclature

LEFT 0 conversion reaction 67 species 72 STOICHIOMETRY
type: Stoichiometry
physical entity: species_72
stoichiometric coefficient: 1.0

species_169
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef
cellular location: Cell

Q8WYR1
type: UnificationXref
id: Q8WYR1
db: UniProt Knowledgebase

LEFT 1 conversion reaction 177 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

species_120
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-degrade
cellular location: Cell

RIGHT 1 conversion reaction 153 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_114
type: PhysicalEntity
member physical entity: Cbl-CIN85
cellular location: Cell

species_17
type: PhysicalEntity
member physical entity: RasGDP
cellular location: Cell

RIGHT 0 conversion reaction 80 species 82 STOICHIOMETRY
type: Stoichiometry
physical entity: species_82
stoichiometric coefficient: 1.0

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

species_158
type: PhysicalEntity
member physical entity: species 158
cellular location: Cell

species_174
type: PhysicalEntity
member physical entity: species 174
cellular location: Cell

species_3
type: PhysicalEntity
member physical entity: EGF-EGFR-2
cellular location: Cell

LEFT 0 conversion reaction 185 species 139 STOICHIOMETRY
type: Stoichiometry
physical entity: species_139
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 76 species 81 STOICHIOMETRY
type: Stoichiometry
physical entity: species_81
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 92 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

http://identifiers.org/pubmed/18505685
type: PublicationXref
id: 18505685
db: PubMed

LEFT 0 conversion reaction 71 species 74 STOICHIOMETRY
type: Stoichiometry
physical entity: species_74
stoichiometric coefficient: 1.0

species_161
type: PhysicalEntity
member physical entity: species 161
cellular location: Cell

RIGHT 0 conversion reaction 169 species 164 STOICHIOMETRY
type: Stoichiometry
physical entity: species_164
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 90 species 95 STOICHIOMETRY
type: Stoichiometry
physical entity: species_95
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 14 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000000205

species_88
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-RasGAP-RasGTP
cellular location: Cell

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

LEFT 1 conversion reaction 78 species 84 STOICHIOMETRY
type: Stoichiometry
physical entity: species_84
stoichiometric coefficient: 1.0

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

BioModels Database
type: Provenance
xref: MODEL7802538336

LEFT 0 conversion reaction 37 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

species_4
type: PhysicalEntity
member physical entity: EGF-pEGFR-2
cellular location: Cell

species_16
type: PhysicalEntity
member physical entity: Grb2-SOS
cellular location: Cell

P12931
type: UnificationXref
id: P12931
db: UniProt Knowledgebase

Q9NZN5
type: UnificationXref
id: Q9NZN5
db: UniProt Knowledgebase

RIGHT 1 conversion reaction 86 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

LEFT 0 conversion reaction 34 species 39 STOICHIOMETRY
type: Stoichiometry
physical entity: species_39
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 174 species 167 STOICHIOMETRY
type: Stoichiometry
physical entity: species_167
stoichiometric coefficient: 1.0

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

LEFT 0 conversion reaction 139 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

species_74
type: PhysicalEntity
member physical entity: PIP3-RacGEF
cellular location: Cell

RIGHT 0 conversion reaction 190 species 185 STOICHIOMETRY
type: Stoichiometry
physical entity: species_185
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 45 species 46 STOICHIOMETRY
type: Stoichiometry
physical entity: species_46
stoichiometric coefficient: 1.0

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

LEFT 0 conversion reaction 87 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 71 species 75 STOICHIOMETRY
type: Stoichiometry
physical entity: species_75
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 161 species 158 STOICHIOMETRY
type: Stoichiometry
physical entity: species_158
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 39 species 33 STOICHIOMETRY
type: Stoichiometry
physical entity: species_33
stoichiometric coefficient: 1.0

species_16
type: PhysicalEntity
member physical entity: Grb2-SOS
cellular location: Cell

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

species_60
type: PhysicalEntity
member physical entity: PDK1
cellular location: Cell

RIGHT 0 conversion reaction 113 species 115 STOICHIOMETRY
type: Stoichiometry
physical entity: species_115
stoichiometric coefficient: 1.0

http://identifiers.org/ec-code/2.7.11.1
type: UnificationXref
id: 2.7.11.1
db: Enzyme Nomenclature

species_12
type: PhysicalEntity
member physical entity: Grb2
cellular location: Cell

RIGHT 0 conversion reaction 61 species 66 STOICHIOMETRY
type: Stoichiometry
physical entity: species_66
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 3 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 159 species 156 STOICHIOMETRY
type: Stoichiometry
physical entity: species_156
stoichiometric coefficient: 1.0

species_21
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SOS
cellular location: Cell

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

RIGHT 0 conversion reaction 46 species 48 STOICHIOMETRY
type: Stoichiometry
physical entity: species_48
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 98 species 94 STOICHIOMETRY
type: Stoichiometry
physical entity: species_94
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 25 species 28 STOICHIOMETRY
type: Stoichiometry
physical entity: species_28
stoichiometric coefficient: 1.0

species_91
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SHP2
cellular location: Cell

RIGHT 0 conversion reaction 35 species 40 STOICHIOMETRY
type: Stoichiometry
physical entity: species_40
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 163 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

species_75
type: PhysicalEntity
member physical entity: RacGDP
cellular location: Cell

species_14
type: PhysicalEntity
member physical entity: SOS
cellular location: Cell

species_105
type: PhysicalEntity
member physical entity: ROK
cellular location: Cell

LEFT 0 conversion reaction 80 species 86 STOICHIOMETRY
type: Stoichiometry
physical entity: species_86
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 53 species 52 STOICHIOMETRY
type: Stoichiometry
physical entity: species_52
stoichiometric coefficient: 1.0

species_59
type: PhysicalEntity
member physical entity: Akt-PIP3
cellular location: Cell

GO:0005089
type: UnificationXref
id: GO:0005089
db: Gene Ontology

LEFT 1 conversion reaction 75 species 80 STOICHIOMETRY
type: Stoichiometry
physical entity: species_80
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 122 species 126 STOICHIOMETRY
type: Stoichiometry
physical entity: species_126
stoichiometric coefficient: 1.0

R98
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 97 species 3 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 97 species 44 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 97 species 100 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 97 species 90 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_90
right: species_44
right: species_3
left: species_100

R97
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 96 species 90 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 96 species 87 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 96 species 100 STOICHIOMETRY
right: species_100
left: species_90
left: species_87

R96
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 95 species 97 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 95 species 99 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 95 species 92 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_97
right: species_92
left: species_99

R95
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 94 species 95 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 94 species 92 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 94 species 99 STOICHIOMETRY
right: species_99
left: species_92
left: species_95

RIGHT 0 conversion reaction 177 species 170 STOICHIOMETRY
type: Stoichiometry
physical entity: species_170
stoichiometric coefficient: 1.0

GO:0005099
type: UnificationXref
id: GO:0005099
db: Gene Ontology

R100
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 99 species 101 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 99 species 84 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 99 species 102 STOICHIOMETRY
xref: GO:0004715
xref: http://identifiers.org/ec-code/2.7.10.2
right: species_101
right: species_84
spontaneous: true
left: species_102
conversion direction: RIGHT_TO_LEFT

GO:0005096
type: UnificationXref
id: GO:0005096
db: Gene Ontology

R99
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 98 species 94 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 98 species 101 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 98 species 102 STOICHIOMETRY
right: species_102
spontaneous: true
left: species_94
left: species_101
conversion direction: LEFT_TO_RIGHT

species_32
type: PhysicalEntity
member physical entity: ppMEK-ERK
cellular location: Cell

species_57
type: PhysicalEntity
member physical entity: PIP3
cellular location: Cell

R94
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 93 species 92 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 93 species 94 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 93 species 98 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_92
right: species_94
left: species_98

R93
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 92 species 92 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 92 species 98 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 92 species 84 STOICHIOMETRY
right: species_98
left: species_84
left: species_92

R92
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 91 species 91 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 91 species 96 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 91 species 97 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_91
right: species_97
left: species_96

P28482
type: UnificationXref
id: P28482
db: UniProt Knowledgebase

R91
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 90 species 96 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 90 species 95 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 90 species 91 STOICHIOMETRY
right: species_96
left: species_91
left: species_95

LEFT 0 conversion reaction 134 species 136 STOICHIOMETRY
type: Stoichiometry
physical entity: species_136
stoichiometric coefficient: 1.0

species_186
type: PhysicalEntity
member physical entity: species 186
cellular location: Cell

P04049
type: UnificationXref
id: P04049
db: UniProt Knowledgebase

species_36
type: PhysicalEntity
member physical entity: Pase
cellular location: Cell

RIGHT 1 conversion reaction 47 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_17
type: PhysicalEntity
member physical entity: RasGDP
cellular location: Cell

RIGHT 0 conversion reaction 51 species 54 STOICHIOMETRY
type: Stoichiometry
physical entity: species_54
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 42 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_180
type: PhysicalEntity
member physical entity: species 180
cellular location: Cell

species_128
type: PhysicalEntity
member physical entity: Ras-GTP-RhoGEF
cellular location: Cell

species_132
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abcdef
cellular location: Cell

GO:0005068
type: UnificationXref
id: GO:0005068
db: Gene Ontology

RIGHT 0 conversion reaction 109 species 110 STOICHIOMETRY
type: Stoichiometry
physical entity: species_110
stoichiometric coefficient: 1.0

species_90
type: PhysicalEntity
member physical entity: SHP2
cellular location: Cell

LEFT 1 conversion reaction 115 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 188 species 183 STOICHIOMETRY
type: Stoichiometry
physical entity: species_183
stoichiometric coefficient: 1.0

R76
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 75 species 77 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 75 species 80 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 75 species 81 STOICHIOMETRY
xref: GO:0005096
right: species_81
left: species_77
left: species_80

R75
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 74 species 75 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 74 species 77 STOICHIOMETRY
xref: GO:0005096
right: species_75
left: species_77

R74
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 73 species 75 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 73 species 78 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 73 species 79 STOICHIOMETRY
xref: GO:0006461
right: species_79
left: species_78
left: species_75

GO:0005070
type: UnificationXref
id: GO:0005070
db: Gene Ontology

R73
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 72 species 77 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 72 species 76 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 72 species 74 STOICHIOMETRY
xref: GO:0005089
right: species_74
right: species_77
spontaneous: true
left: species_76
conversion direction: LEFT_TO_RIGHT

R80
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 79 species 85 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 79 species 84 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 79 species 86 STOICHIOMETRY
xref: GO:0005089
right: species_86
right: species_84
left: species_85

R79
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 78 species 85 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 78 species 82 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 78 species 84 STOICHIOMETRY
xref: GO:0005089
right: species_85
left: species_82
left: species_84

P52565
type: UnificationXref
id: P52565
db: UniProt Knowledgebase

R78
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 77 species 83 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 77 species 78 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 77 species 82 STOICHIOMETRY
xref: GO:0006461
right: species_83
left: species_82
left: species_78

R77
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 76 species 80 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 76 species 81 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 76 species 75 STOICHIOMETRY
xref: GO:0005096
right: species_80
right: species_75
left: species_81

RIGHT 1 conversion reaction 97 species 44 STOICHIOMETRY
type: Stoichiometry
physical entity: species_44
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 26 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

R72
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 71 species 76 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 71 species 74 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 71 species 75 STOICHIOMETRY
xref: GO:0005089
right: species_76
spontaneous: true
left: species_74
left: species_75
conversion direction: RIGHT_TO_LEFT

R71
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 70 species 74 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 70 species 57 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 70 species 73 STOICHIOMETRY
xref: GO:0005089
right: species_74
spontaneous: true
left: species_57
left: species_73
conversion direction: LEFT_TO_RIGHT

species_106
type: PhysicalEntity
member physical entity: RhoGTP-ROK
cellular location: Cell

species_41
type: PhysicalEntity
member physical entity: MKP3
cellular location: Cell

species_84
type: PhysicalEntity
member physical entity: pRhoGEF
cellular location: Cell

R87
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 86 species 3 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 86 species 12 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 86 species 10 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion reaction 86 species 90 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 86 species 91 STOICHIOMETRY
xref: GO:0043241
right: species_12
right: species_3
right: species_10
right: species_90
left: species_91

species_19
type: PhysicalEntity
member physical entity: RasGTP
cellular location: Cell

R86
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 85 species 90 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 85 species 20 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 85 species 92 STOICHIOMETRY
xref: GO:0006461
right: species_92
left: species_20
left: species_90

R85
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 84 species 91 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 84 species 90 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 84 species 13 STOICHIOMETRY
xref: GO:0006461
right: species_91
left: species_90
left: species_13

R84
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 83 species 89 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 83 species 88 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 83 species 17 STOICHIOMETRY
xref: GO:0005099
xref: GO:0005085
right: species_17
right: species_89
spontaneous: true
left: species_88
conversion direction: LEFT_TO_RIGHT

R90
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 89 species 91 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 89 species 94 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 89 species 93 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_91
right: species_94
left: species_93

species_190
type: PhysicalEntity
member physical entity: species 190
cellular location: Cell

R89
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 88 species 93 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 88 species 84 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 88 species 91 STOICHIOMETRY
xref: GO:0006461
right: species_93
left: species_84
left: species_91

GO:0005085
type: UnificationXref
id: GO:0005085
db: Gene Ontology

R88
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 87 species 3 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 87 species 90 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 87 species 92 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 87 species 12 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.48
xref: GO:0004725
right: species_12
right: species_90
right: species_3
left: species_92

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

species_79
type: PhysicalEntity
member physical entity: RhoGDI-RacGDP
cellular location: Cell

LEFT 0 conversion reaction 35 species 28 STOICHIOMETRY
type: Stoichiometry
physical entity: species_28
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 61 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

R83
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 82 species 19 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 82 species 87 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 82 species 88 STOICHIOMETRY
xref: GO:0006461
right: species_88
spontaneous: true
left: species_19
left: species_87
conversion direction: RIGHT_TO_LEFT

R82
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 81 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 81 species 87 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 81 species 44 STOICHIOMETRY
xref: GO:0006461
right: species_87
left: species_4
left: species_44

R81
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 80 species 82 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 80 species 86 STOICHIOMETRY
xref: GO:0005096
right: species_82
left: species_86

RIGHT 0 conversion reaction 123 species 117 STOICHIOMETRY
type: Stoichiometry
physical entity: species_117
stoichiometric coefficient: 1.0

species_11
type: PhysicalEntity
member physical entity: pShc-SHP
cellular location: Cell

species_155
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abppMEKcdefRasGTP
cellular location: Cell

R60
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 59 species 64 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 59 species 62 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 59 species 65 STOICHIOMETRY
xref: GO:0006461
right: species_65
left: species_64
left: species_62

R59
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 58 species 57 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 58 species 62 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 58 species 63 STOICHIOMETRY
xref: GO:0043241
right: species_57
right: species_63
spontaneous: true
left: species_62
conversion direction: RIGHT_TO_LEFT

RIGHT 0 conversion reaction 10 species 13 STOICHIOMETRY
type: Stoichiometry
physical entity: species_13
stoichiometric coefficient: 1.0

R54
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 53 species 52 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 53 species 55 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 53 species 56 STOICHIOMETRY
xref: GO:0005515
right: species_56
spontaneous: true
left: species_52
left: species_55
conversion direction: LEFT_TO_RIGHT

R53
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 52 species 49 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 52 species 53 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 52 species 54 STOICHIOMETRY
xref: GO:0006470
right: species_49
right: species_53
spontaneous: true
left: species_54
conversion direction: RIGHT_TO_LEFT

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

R52
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 51 species 53 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 51 species 52 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 51 species 54 STOICHIOMETRY
xref: GO:0006461
right: species_54
spontaneous: true
left: species_52
left: species_53
conversion direction: LEFT_TO_RIGHT

R51
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 50 species 50 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 50 species 52 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 50 species 51 STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.10.1
right: species_51
right: species_52
left: species_50

R58
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 57 species 62 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 57 species 60 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 57 species 61 STOICHIOMETRY
xref: http://identifiers.org/ec-code/2.7.11.1
xref: GO:0006468
right: species_60
right: species_62
left: species_61

LEFT 1 conversion reaction 105 species 105 STOICHIOMETRY
type: Stoichiometry
physical entity: species_105
stoichiometric coefficient: 1.0

R57
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 56 species 59 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 56 species 60 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 56 species 61 STOICHIOMETRY
xref: GO:0006461
right: species_61
left: species_59
left: species_60

RIGHT 0 conversion reaction 53 species 56 STOICHIOMETRY
type: Stoichiometry
physical entity: species_56
stoichiometric coefficient: 1.0

R56
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 55 species 59 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 55 species 58 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 55 species 57 STOICHIOMETRY
xref: GO:0006461
right: species_59
spontaneous: true
left: species_58
left: species_57
conversion direction: LEFT_TO_RIGHT

R55
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 54 species 52 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 54 species 57 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 54 species 56 STOICHIOMETRY
xref: GO:0043241
right: species_57
right: species_52
spontaneous: true
left: species_56
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 104 species 104 STOICHIOMETRY
type: Stoichiometry
physical entity: species_104
stoichiometric coefficient: 1.0

species_149
type: PhysicalEntity
member physical entity: species 149
cellular location: Cell

LEFT 0 conversion reaction 10 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

species_140
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
cellular location: Cell

species_66
type: PhysicalEntity
member physical entity: pRaf-pAkt-PIP3
cellular location: Cell

species_31
type: PhysicalEntity
member physical entity: ERK
cellular location: Cell

species_160
type: PhysicalEntity
member physical entity: species 160
cellular location: Cell

species_192
type: PhysicalEntity
member physical entity: species 192
cellular location: Cell

R70
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 69 species 55 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 69 species 57 STOICHIOMETRY
xref: GO:0004445
right: species_55
left: species_57

RIGHT 0 conversion reaction 4 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

R65
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 64 species 69 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 64 species 70 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 64 species 68 STOICHIOMETRY
xref: GO:0005515
right: species_70
spontaneous: true
left: species_68
left: species_69
conversion direction: LEFT_TO_RIGHT

R64
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 63 species 25 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 63 species 67 STOICHIOMETRY
xref: GO:0006470
right: species_25
left: species_67

R63
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 62 species 67 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 62 species 66 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 62 species 62 STOICHIOMETRY
xref: GO:0043241
right: species_62
right: species_67
left: species_66

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

R62
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 61 species 66 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 61 species 62 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 61 species 25 STOICHIOMETRY
xref: GO:0006461
right: species_66
left: species_62
left: species_25

R69
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 68 species 71 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 68 species 69 STOICHIOMETRY
xref: GO:0006470
right: species_69
left: species_71

species_25
type: PhysicalEntity
member physical entity: pRaf
cellular location: Cell

LEFT 1 conversion reaction 29 species 33 STOICHIOMETRY
type: Stoichiometry
physical entity: species_33
stoichiometric coefficient: 1.0

R68
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 67 species 72 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 67 species 55 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 67 species 71 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.67
right: species_71
right: species_55
spontaneous: true
left: species_72
conversion direction: RIGHT_TO_LEFT

R67
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 66 species 57 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 66 species 71 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 66 species 72 STOICHIOMETRY
xref: GO:0005515
right: species_72
spontaneous: true
left: species_71
left: species_57
conversion direction: LEFT_TO_RIGHT

species_62
type: PhysicalEntity
member physical entity: pAkt-PIP3
cellular location: Cell

R66
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 65 species 71 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 65 species 68 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 65 species 70 STOICHIOMETRY
xref: GO:0004674
xref: http://identifiers.org/ec-code/2.7.11.1
right: species_68
right: species_71
spontaneous: true
left: species_70
conversion direction: RIGHT_TO_LEFT

R61
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 60 species 59 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 60 species 65 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 60 species 64 STOICHIOMETRY
xref: GO:0043241
right: species_59
right: species_64
left: species_65

species_41
type: PhysicalEntity
member physical entity: MKP3
cellular location: Cell

species_135
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1abpMEKcdef
cellular location: Cell

P07522
type: UnificationXref
id: P07522
db: UniProt Knowledgebase

RIGHT 2 conversion reaction 47 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

R40
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 39 species 41 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 39 species 33 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 39 species 43 STOICHIOMETRY
xref: GO:0006461
right: species_43
spontaneous: true
left: species_33
left: species_41
conversion direction: LEFT_TO_RIGHT

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

R39
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 38 species 42 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 38 species 33 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 38 species 41 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0004721
right: species_33
right: species_41
spontaneous: true
left: species_42
conversion direction: RIGHT_TO_LEFT

species_35
type: PhysicalEntity
member physical entity: ppERK
cellular location: Cell

R38
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 37 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 37 species 41 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 37 species 42 STOICHIOMETRY
xref: GO:0019902
right: species_42
spontaneous: true
left: species_41
left: species_35
conversion direction: LEFT_TO_RIGHT

R37
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 36 species 26 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 36 species 40 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 36 species 38 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0004721
right: species_38
right: species_26
spontaneous: true
left: species_40
conversion direction: RIGHT_TO_LEFT

RIGHT 3 conversion reaction 86 species 90 STOICHIOMETRY
type: Stoichiometry
physical entity: species_90
stoichiometric coefficient: 1.0

species_137
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1abMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 37 species 42 STOICHIOMETRY
type: Stoichiometry
physical entity: species_42
stoichiometric coefficient: 1.0

R32
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 31 species 37 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 31 species 25 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 31 species 36 STOICHIOMETRY
xref: GO:0019902
right: species_37
spontaneous: true
left: species_25
left: species_36
conversion direction: LEFT_TO_RIGHT

R31
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 30 species 34 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 30 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 30 species 30 STOICHIOMETRY
xref: GO:0004708
xref: GO:0043241
xref: http://identifiers.org/ec-code/2.7.12.2
right: species_30
right: species_35
spontaneous: true
left: species_34
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 153 species 151 STOICHIOMETRY
type: Stoichiometry
physical entity: species_151
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 189 species 31 STOICHIOMETRY
type: Stoichiometry
physical entity: species_31
stoichiometric coefficient: 1.0

species_140
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-MEKK1aRafbcdef
cellular location: Cell

R36
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 35 species 40 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 35 species 38 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 35 species 28 STOICHIOMETRY
xref: GO:0019902
right: species_40
spontaneous: true
left: species_38
left: species_28
conversion direction: LEFT_TO_RIGHT

R35
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 34 species 38 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 34 species 39 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 34 species 28 STOICHIOMETRY
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0004721
right: species_38
right: species_28
spontaneous: true
left: species_39
conversion direction: RIGHT_TO_LEFT

R34
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 33 species 38 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 33 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 33 species 39 STOICHIOMETRY
xref: GO:0019902
right: species_39
spontaneous: true
left: species_30
left: species_38
conversion direction: LEFT_TO_RIGHT

R33
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 32 species 37 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 32 species 36 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 32 species 23 STOICHIOMETRY
xref: GO:0016791
right: species_36
right: species_23
spontaneous: true
left: species_37
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 72 species 76 STOICHIOMETRY
type: Stoichiometry
physical entity: species_76
stoichiometric coefficient: 1.0

species_85
type: PhysicalEntity
member physical entity: RhoGDP-pRhoGEF
cellular location: Cell

RIGHT 0 conversion reaction 95 species 92 STOICHIOMETRY
type: Stoichiometry
physical entity: species_92
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 27 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

species_29
type: PhysicalEntity
member physical entity: pRaf-pMEK
cellular location: Cell

species_23
type: PhysicalEntity
member physical entity: Raf
cellular location: Cell

R50
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 49 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 49 species 50 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 49 species 49 STOICHIOMETRY
xref: GO:0043548
right: species_50
left: species_49
left: species_4

RIGHT 0 conversion reaction 120 species 123 STOICHIOMETRY
type: Stoichiometry
physical entity: species_123
stoichiometric coefficient: 1.0

R49
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 48 species 14 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 48 species 47 STOICHIOMETRY
xref: GO:0006470
right: species_14
left: species_47

R48
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion reaction 47 species 12 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 47 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion reaction 47 species 47 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 47 species 48 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 47 species 4 STOICHIOMETRY
xref: GO:0043241
right: species_47
right: species_4
right: species_12
right: species_35
left: species_48

species_117
type: PhysicalEntity
member physical entity: EPn
cellular location: Cell

LEFT 0 conversion reaction 93 species 98 STOICHIOMETRY
type: Stoichiometry
physical entity: species_98
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 17 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

R43
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 42 species 19 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 42 species 44 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 42 species 45 STOICHIOMETRY
xref: GO:0006461
xref: GO:0017016
right: species_45
left: species_19
left: species_44

R42
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 41 species 19 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 41 species 17 STOICHIOMETRY
xref: GO:0006470
xref: http://identifiers.org/ec-code/3.1.3.16
xref: GO:0046580
right: species_17
left: species_19

LEFT 0 conversion reaction 133 species 135 STOICHIOMETRY
type: Stoichiometry
physical entity: species_135
stoichiometric coefficient: 1.0

R41
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 40 species 41 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 40 species 43 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 40 species 31 STOICHIOMETRY
xref: GO:0004725
xref: http://identifiers.org/ec-code/3.1.3.16
right: species_31
right: species_41
spontaneous: true
left: species_43
conversion direction: RIGHT_TO_LEFT

species_158
type: PhysicalEntity
member physical entity: species 158
cellular location: Cell

R47
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 46 species 48 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 46 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 46 species 21 STOICHIOMETRY
xref: GO:0006461
right: species_48
left: species_21
left: species_35

R46
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 45 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 4 conversion reaction 45 species 47 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 45 species 35 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 45 species 46 STOICHIOMETRY
participant stoichiometry: RIGHT 2 conversion reaction 45 species 10 STOICHIOMETRY
participant stoichiometry: RIGHT 3 conversion reaction 45 species 12 STOICHIOMETRY
xref: GO:0043241
right: species_4
right: species_12
right: species_47
right: species_10
right: species_35
left: species_46

R45
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 44 species 15 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 44 species 35 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 44 species 46 STOICHIOMETRY
xref: GO:0006461
right: species_46
left: species_15
left: species_35

R44
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion reaction 43 species 44 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 43 species 45 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 43 species 17 STOICHIOMETRY
xref: GO:0005099
right: species_44
right: species_17
left: species_45

LEFT 1 conversion reaction 140 species 26 STOICHIOMETRY
type: Stoichiometry
physical entity: species_26
stoichiometric coefficient: 1.0

GO:0017016
type: UnificationXref
id: GO:0017016
db: Gene Ontology

LEFT 1 conversion reaction 56 species 60 STOICHIOMETRY
type: Stoichiometry
physical entity: species_60
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

R18
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 17 species 20 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 17 species 14 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 17 species 21 STOICHIOMETRY
xref: GO:0005515
right: species_21
left: species_14
left: species_20

species_176
type: PhysicalEntity
member physical entity: species 176
cellular location: Cell

R17
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 16 species 20 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 16 species 4 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 16 species 12 STOICHIOMETRY
xref: GO:0005515
right: species_20
left: species_12
left: species_4

species_37
type: PhysicalEntity
member physical entity: pRaf-Pase
cellular location: Cell

R16
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 15 species 19 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 15 species 18 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 15 species 15 STOICHIOMETRY
xref: GO:0005525
right: species_19
right: species_15
spontaneous: true
left: species_18
conversion direction: LEFT_TO_RIGHT

R15
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 14 species 15 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 14 species 18 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 14 species 17 STOICHIOMETRY
xref: GO:0005515
right: species_18
spontaneous: true
left: species_15
left: species_17
conversion direction: RIGHT_TO_LEFT

species_94
type: PhysicalEntity
member physical entity: RhoGEF
cellular location: Cell

species_118
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS-Cbl-CIN85-EPn
cellular location: Cell

RIGHT 1 conversion reaction 166 species 35 STOICHIOMETRY
type: Stoichiometry
physical entity: species_35
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 57 species 61 STOICHIOMETRY
type: Stoichiometry
physical entity: species_61
stoichiometric coefficient: 1.0

R20
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 19 species 17 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 19 species 22 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 19 species 21 STOICHIOMETRY
xref: GO:0005070
right: species_22
spontaneous: true
left: species_17
left: species_21
conversion direction: RIGHT_TO_LEFT

RIGHT 1 conversion reaction 121 species 124 STOICHIOMETRY
type: Stoichiometry
physical entity: species_124
stoichiometric coefficient: 1.0

species_13
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2
cellular location: Cell

R19
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 18 species 4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 18 species 21 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 18 species 16 STOICHIOMETRY
xref: GO:0051425
xref: GO:0042169
right: species_21
spontaneous: true
left: species_4
left: species_16
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion reaction 131 species 132 STOICHIOMETRY
type: Stoichiometry
physical entity: species_132
stoichiometric coefficient: 1.0

R14
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion reaction 13 species 16 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 13 species 15 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 13 species 9 STOICHIOMETRY
xref: GO:0051425
xref: GO:0042169
right: species_15
spontaneous: true
left: species_9
left: species_16
conversion direction: RIGHT_TO_LEFT

R13
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 12 species 12 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 12 species 14 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 12 species 16 STOICHIOMETRY
xref: GO:0005515
right: species_16
spontaneous: true
left: species_14
left: species_12
conversion direction: LEFT_TO_RIGHT

R12
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 11 species 13 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 11 species 15 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 11 species 14 STOICHIOMETRY
xref: GO:0005070
xref: GO:0005068
xref: GO:0017124
right: species_15
left: species_14
left: species_13

R11
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion reaction 10 species 12 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 10 species 13 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 10 species 9 STOICHIOMETRY
xref: GO:0051425
xref: GO:0042169
right: species_13
left: species_9
left: species_12

LEFT 1 conversion reaction 122 species 125 STOICHIOMETRY
type: Stoichiometry
physical entity: species_125
stoichiometric coefficient: 1.0

species_92
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-SHP2
cellular location: Cell

species_81
type: PhysicalEntity
member physical entity: RacGTP-RacGAP
cellular location: Cell

species_9
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc
cellular location: Cell

species_188
type: PhysicalEntity
member physical entity: species 188
cellular location: Cell

R29
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 28 species 32 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 28 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 28 species 33 STOICHIOMETRY
xref: GO:0004708
xref: http://identifiers.org/ec-code/2.7.12.2
xref: GO:0000187
right: species_30
right: species_33
spontaneous: true
left: species_32
conversion direction: RIGHT_TO_LEFT

R28
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 27 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 27 species 32 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 27 species 31 STOICHIOMETRY
xref: GO:0006461
xref: GO:0000187
right: species_32
spontaneous: true
left: species_30
left: species_31
conversion direction: LEFT_TO_RIGHT

R27
type: ComplexAssembly
participant stoichiometry: RIGHT 1 conversion reaction 26 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 26 species 25 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 26 species 29 STOICHIOMETRY
xref: GO:0043241
xref: GO:0004674
xref: http://identifiers.org/ec-code/2.7.11.1
right: species_30
right: species_25
spontaneous: true
left: species_29
conversion direction: RIGHT_TO_LEFT

R26
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 25 species 25 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 25 species 28 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 25 species 29 STOICHIOMETRY
xref: GO:0006461
right: species_29
spontaneous: true
left: species_28
left: species_25
conversion direction: LEFT_TO_RIGHT

species_169
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1apRafbppMEKcdef
cellular location: Cell

RIGHT 0 conversion reaction 73 species 79 STOICHIOMETRY
type: Stoichiometry
physical entity: species_79
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 3 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

species_111
type: PhysicalEntity
member physical entity: TP7
cellular location: Cell

R30
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 29 species 30 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 29 species 33 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 29 species 34 STOICHIOMETRY
xref: GO:0006461
right: species_34
spontaneous: true
left: species_33
left: species_30
conversion direction: LEFT_TO_RIGHT

species_26
type: PhysicalEntity
member physical entity: MEK
cellular location: Cell

R21
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion reaction 20 species 22 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 20 species 21 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 20 species 19 STOICHIOMETRY
xref: GO:0046579
right: species_21
right: species_19
spontaneous: true
left: species_22
conversion direction: LEFT_TO_RIGHT

LEFT 0 conversion reaction 81 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

R25
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 24 species 25 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 24 species 28 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 24 species 27 STOICHIOMETRY
xref: GO:0043241
xref: GO:0004674
xref: http://identifiers.org/ec-code/2.7.11.1
right: species_28
right: species_25
spontaneous: true
left: species_27
conversion direction: RIGHT_TO_LEFT

R24
type: ComplexAssembly
participant stoichiometry: RIGHT 0 conversion reaction 23 species 27 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 23 species 25 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 23 species 26 STOICHIOMETRY
xref: GO:0005515
right: species_27
spontaneous: true
left: species_25
left: species_26
conversion direction: LEFT_TO_RIGHT

R23
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 22 species 25 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion reaction 22 species 19 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 22 species 24 STOICHIOMETRY
xref: GO:0043241
xref: GO:0006468
right: species_19
right: species_25
left: species_24

R22
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 21 species 23 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 21 species 24 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 21 species 19 STOICHIOMETRY
xref: GO:0000185
right: species_24
left: species_23
left: species_19

RIGHT 0 conversion reaction 183 species 180 STOICHIOMETRY
type: Stoichiometry
physical entity: species_180
stoichiometric coefficient: 1.0

species_95
type: PhysicalEntity
member physical entity: pRhoGAP
cellular location: Cell

species_30
type: PhysicalEntity
member physical entity: ppMEK
cellular location: Cell

species_62
type: PhysicalEntity
member physical entity: pAkt-PIP3
cellular location: Cell

species_68
type: PhysicalEntity
member physical entity: pROK
cellular location: Cell

LEFT 0 conversion reaction 175 species 168 STOICHIOMETRY
type: Stoichiometry
physical entity: species_168
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 197 species 190 STOICHIOMETRY
type: Stoichiometry
physical entity: species_190
stoichiometric coefficient: 1.0

P20936
type: UnificationXref
id: P20936
db: UniProt Knowledgebase

LEFT 1 conversion reaction 59 species 64 STOICHIOMETRY
type: Stoichiometry
physical entity: species_64
stoichiometric coefficient: 1.0

species_15
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-pShc-Grb2-SOS
cellular location: Cell

RIGHT 0 conversion reaction 115 species 118 STOICHIOMETRY
type: Stoichiometry
physical entity: species_118
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 143 species 143 STOICHIOMETRY
type: Stoichiometry
physical entity: species_143
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 201 species 192 STOICHIOMETRY
type: Stoichiometry
physical entity: species_192
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 160 species 157 STOICHIOMETRY
type: Stoichiometry
physical entity: species_157
stoichiometric coefficient: 1.0

species_86
type: PhysicalEntity
member physical entity: RhoGTP
cellular location: Cell

LEFT 1 conversion reaction 33 species 38 STOICHIOMETRY
type: Stoichiometry
physical entity: species_38
stoichiometric coefficient: 1.0

species_146
type: PhysicalEntity
member physical entity: EGF-pEGFR-2-Grb2-MEKK1aRafbpMEKcdef
cellular location: Cell

LEFT 0 conversion reaction 109 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_28
type: PhysicalEntity
member physical entity: pMEK
cellular location: Cell

RIGHT 0 conversion reaction 105 species 106 STOICHIOMETRY
type: Stoichiometry
physical entity: species_106
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 176 species 166 STOICHIOMETRY
type: Stoichiometry
physical entity: species_166
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 26 species 29 STOICHIOMETRY
type: Stoichiometry
physical entity: species_29
stoichiometric coefficient: 1.0