Smith1980 - Hypothalamic Regulation
This a model from the article:
Hypothalamic regulation of pituitary secretion of luteinizing hormone.II. Feedback control of gonadotropin secretion.
Smith WR Bull Math Biol.
(1980) 42(1): 57-78 6986927
,
Abstract:
No Abstract Available
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
smith,1980,version02
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@auckland.ac.nz
The University of Auckland
Auckland Bioengineering Institute
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Hypothalamic regulation of pituitary secretion of luteinizing hormone. II. Feedback control of gonadotropin secretion.
- Smith WR.
- Bull. Math. Biol. 1980; 42(1): 57-78 , 1/ 1980 , Volume 42 , Issue 1 , pages: 57-78 , PubMed ID: 6986927
- Department of Mathematics Biophysics, Dalhousie University, Halifax, Nova Scotia, B3H 4H8, Canada
- A general mathematical model describing the biochemical interactions of the hormones luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH) and testosterone (T) in the male is presented. The model structure consists of a negative feedback system of three ordinary differential equations, in which the quali]ative behavior is either a stable constant equilibrium solution or oscillatory solutions. A specific realization of the model is used to describe the experimental observations of pulsatile hormone release, its experimental suppression, the onset of puberty, the effects of castration, and several other qualitative and quantitative results. This model is presented as a first step in understanding the physi- cochemical interactions of the hypothalamic pituitary gonadal axis.
Submitter of this revision: Mohammad Umer Sharif Shohan
Modellers: Vijayalakshmi Chelliah, Mohammad Umer Sharif Shohan
Metadata information
isDescribedBy (3 statements)
hasTaxon (1 statement)
isInstanceOf (5 statements)
Taxonomy Bos taurus
Gene Ontology gonadotropin secretion
BioModels Database MODEL7898438988
Gene Ontology luteinizing hormone secretion
hasProperty (2 statements)
BioModels Database MODEL7898438988
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
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| Smith1980_HypothalamicRegulation.xml | SBML L2V4 Hypothalamic Regulation model | 38.94 KB | Preview | Download |
Additional files |
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| MODEL7898438988-biopax2.owl | Auto-generated BioPAX (Level 2) | 1.05 KB | Preview | Download |
| MODEL7898438988-biopax3.owl | Auto-generated BioPAX (Level 3) | 2.00 KB | Preview | Download |
| MODEL7898438988.m | Auto-generated Octave file | 2.47 KB | Preview | Download |
| MODEL7898438988.pdf | Auto-generated PDF file | 132.85 KB | Preview | Download |
| MODEL7898438988.png | Auto-generated Reaction graph (PNG) | 5.04 KB | Preview | Download |
| MODEL7898438988.sci | Auto-generated Scilab file | 203.00 Bytes | Preview | Download |
| MODEL7898438988.svg | Auto-generated Reaction graph (SVG) | 851.00 Bytes | Preview | Download |
| MODEL7898438988.vcml | Auto-generated VCML file | 900.00 Bytes | Preview | Download |
| MODEL7898438988.xpp | Auto-generated XPP file | 1.63 KB | Preview | Download |
| MODEL7898438988_url.xml | old xml file | 8.26 KB | Preview | Download |
| MODEL7898438988_urn.xml | Auto-generated SBML file with URNs | 8.79 KB | Preview | Download |
| Smith1980_HypothalamicRegulation.cps | COPASI version 4.24 (Build 197) Hypothalamic Regulation model | 60.06 KB | Preview | Download |
| Smith1980_HypothalamicRegulation.sedml | SEDML L1V2 Hypothalamic Regulation model | 1.01 KB | Preview | Download |
- Model originally submitted by : Vijayalakshmi Chelliah
- Submitted: Mar 25, 2009 12:00:52 PM
- Last Modified: Oct 9, 2019 5:00:50 PM
Revisions
-
Version: 7
- Submitted on: Oct 9, 2019 5:00:50 PM
- Submitted by: Mohammad Umer Sharif Shohan
- With comment: Automatically added model identifier BIOMD0000000831
-
Version: 2
- Submitted on: Mar 25, 2009 12:00:52 PM
- Submitted by: Vijayalakshmi Chelliah
- With comment: Current version of Smith1980_HypothalamicRegulation
-
Version: 1
- Submitted on: Mar 25, 2009 12:00:52 PM
- Submitted by: Vijayalakshmi Chelliah
- With comment: Original import of Smith1980_HypothalamicRegulation
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revisions as only public revisions are displayed here. Any private revisions
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: Variable used inside SBML models
| Species | Initial Concentration/Amount |
|---|---|
| T Thyroxine 5-deiodinase |
15.0 pmol |
| R Luteinizing hormone receptor |
0.5 pmol |
| L Luteinizing hormone |
22.0 pmol |
| Reactions | Rate | Parameters |
|---|---|---|
| T => | Compartment*b3*T | b3 = 1.39 1/h |
| => T; L | Compartment*g2*L | g2 = 0.7 1/h |
| => R; T | Compartment*(c-h*T)*(1-H) | h = 12.0 1/h; H = 1.0 1; c = 100.0 ng/(l*h) |
| => L; R | Compartment*g1*R | g1 = 10.0 1/h |
| L => | Compartment*b2*L | b2 = 0.97 1/h |
| R => | Compartment*b1*R | b1 = 1.29 1/h |
(added: 09 Oct 2019, 16:44:23, updated: 09 Oct 2019, 16:44:23)