Smith1980 - Hypothalamic Regulation

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Short description

This a model from the article:
Hypothalamic regulation of pituitary secretion of luteinizing hormone.II. Feedback control of gonadotropin secretion.
Smith WR Bull Math Biol. (1980) 42(1): 57-78 6986927 ,
No Abstract Available

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: smith,1980,version02
The original CellML model was created by:
Lloyd, Catherine, May
The University of Auckland
Auckland Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models ( It is copyright (c) 2005-2011 The Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • Hypothalamic regulation of pituitary secretion of luteinizing hormone. II. Feedback control of gonadotropin secretion.
  • Smith WR.
  • Bull. Math. Biol. 1980; 42(1): 57-78 , 1/ 1980 , Volume 42 , Issue 1 , pages: 57-78 , PubMed ID: 6986927
  • Department of Mathematics Biophysics, Dalhousie University, Halifax, Nova Scotia, B3H 4H8, Canada
  • A general mathematical model describing the biochemical interactions of the hormones luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH) and testosterone (T) in the male is presented. The model structure consists of a negative feedback system of three ordinary differential equations, in which the quali]ative behavior is either a stable constant equilibrium solution or oscillatory solutions. A specific realization of the model is used to describe the experimental observations of pulsatile hormone release, its experimental suppression, the onset of puberty, the effects of castration, and several other qualitative and quantitative results. This model is presented as a first step in understanding the physi- cochemical interactions of the hypothalamic pituitary gonadal axis.
Submitter of the first revision: Vijayalakshmi Chelliah
Submitter of this revision: Mohammad Umer Sharif Shohan
Modellers: Vijayalakshmi Chelliah, Mohammad Umer Sharif Shohan

Metadata information

is (2 statements)
BioModels Database BIOMD0000000831
BioModels Database MODEL7898438988

isDescribedBy (3 statements)
PubMed 6986927
Gene Ontology gonadotropin secretion
Gene Ontology luteinizing hormone secretion

hasTaxon (1 statement)
Taxonomy Bos taurus

isInstanceOf (5 statements)
Mathematical Modelling Ontology Ordinary differential equation model
Taxonomy Bos taurus
Gene Ontology gonadotropin secretion
BioModels Database MODEL7898438988
Gene Ontology luteinizing hormone secretion

hasProperty (2 statements)
Mathematical Modelling Ontology Ordinary differential equation model
BioModels Database MODEL7898438988

Curation status


Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files

Smith1980_HypothalamicRegulation.xml SBML L2V4 Hypothalamic Regulation model 38.94 KB Preview | Download

Additional files

MODEL7898438988-biopax2.owl Auto-generated BioPAX (Level 2) 1.05 KB Preview | Download
MODEL7898438988-biopax3.owl Auto-generated BioPAX (Level 3) 2.00 KB Preview | Download
MODEL7898438988.m Auto-generated Octave file 2.47 KB Preview | Download
MODEL7898438988.pdf Auto-generated PDF file 132.85 KB Preview | Download
MODEL7898438988.png Auto-generated Reaction graph (PNG) 5.04 KB Preview | Download
MODEL7898438988.sci Auto-generated Scilab file 203.00 Bytes Preview | Download
MODEL7898438988.svg Auto-generated Reaction graph (SVG) 851.00 Bytes Preview | Download
MODEL7898438988.vcml Auto-generated VCML file 900.00 Bytes Preview | Download
MODEL7898438988.xpp Auto-generated XPP file 1.63 KB Preview | Download
MODEL7898438988_url.xml old xml file 8.26 KB Preview | Download
MODEL7898438988_urn.xml Auto-generated SBML file with URNs 8.79 KB Preview | Download
Smith1980_HypothalamicRegulation.cps COPASI version 4.24 (Build 197) Hypothalamic Regulation model 60.06 KB Preview | Download
Smith1980_HypothalamicRegulation.sedml SEDML L1V2 Hypothalamic Regulation model 1.01 KB Preview | Download

  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: Mar 25, 2009 12:00:52 PM
  • Last Modified: Oct 9, 2019 5:00:50 PM
  • Version: 7 public model Download this version
    • Submitted on: Oct 9, 2019 5:00:50 PM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Automatically added model identifier BIOMD0000000831
  • Version: 2 public model Download this version
    • Submitted on: Mar 25, 2009 12:00:52 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Smith1980_HypothalamicRegulation
  • Version: 1 public model Download this version
    • Submitted on: Mar 25, 2009 12:00:52 PM
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Smith1980_HypothalamicRegulation

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

: Variable used inside SBML models

Species Initial Concentration/Amount

Thyroxine 5-deiodinase
15.0 pmol

Luteinizing hormone receptor
0.5 pmol

Luteinizing hormone
22.0 pmol
Reactions Rate Parameters
T => Compartment*b3*T b3 = 1.39 1/h
=> T; L Compartment*g2*L g2 = 0.7 1/h
=> R; T Compartment*(c-h*T)*(1-H) h = 12.0 1/h; H = 1.0 1; c = 100.0 ng/(l*h)
=> L; R Compartment*g1*R g1 = 10.0 1/h
L => Compartment*b2*L b2 = 0.97 1/h
R => Compartment*b1*R b1 = 1.29 1/h
Curator's comment:
(added: 09 Oct 2019, 16:44:23, updated: 09 Oct 2019, 16:44:23)
Model is encoded using COPASI 4.24 (Build197) and plots are generated using R ggplot package. Model simulation time is 20 hour. Figure 2 and Figure 4 of the published model has been reproduced. Although Figures are not exact but similar. The submitted xml file had difference in the equation for formation of LHRH compared to the one present in the paper (Refer to equation no 26 in paper). With the data provided in the paper similar to figure 2 and figure 4 were reproduced but not exact. The patterns were similar. Although using the equation (Refer to equation 26 in paper) provided in the paper, the figure was not reproducible.