Geci2022

  public model
Model Identifier
MODEL2301120001
Short description
The population genetics and population dynamics model describes how a gene drive would increase in frequency through its molecular activities and then suppress a population
Format
Other
Related Publication
  • Gene drive designs for efficient and localisable population suppression using Y-linked editors.
  • René Geci, Willis K, Burt A
  • PLoS genetics , 12/ 2022 , Volume 18 , Issue 12 , pages: e1010550 , DOI: 10.1371/journal.pgen.1010550
  • Dept. of Life Sciences, Imperial College London, Silwood Park, United Kingdom.
  • The sterile insect technique (SIT) has been successful in controlling some pest species but is not practicable for many others due to the large number of individuals that need to be reared and released. Previous computer modelling has demonstrated that the release of males carrying a Y-linked editor that kills or sterilises female descendants could be orders of magnitude more efficient than SIT while still remaining spatially restricted, particularly if combined with an autosomal sex distorter. In principle, further gains in efficiency could be achieved by using a self-propagating double drive design, in which each of the two components (the Y-linked editor and the sex ratio distorter) boosted the transmission of the other. To better understand the expected dynamics and impact of releasing constructs of this new design we have analysed a deterministic population genetic and population dynamic model. Our modelling demonstrates that this design can suppress a population from very low release rates, with no invasion threshold. Importantly, the design can work even if homing rates are low and sex chromosomes are silenced at meiosis, potentially expanding the range of species amenable to such control. Moreover, the predicted dynamics and impacts can be exquisitely sensitive to relatively small (e.g., 25%) changes in allele frequencies in the target population, which could be exploited for sequence-based population targeting. Analysis of published Anopheles gambiae genome sequences indicates that even for weakly differentiated populations with an FST of 0.02 there may be thousands of suitably differentiated genomic sites that could be used to restrict the spread and impact of a release. Our proposed design, which extends an already promising development pathway based on Y-linked editors, is therefore a potentially useful addition to the menu of options for genetic biocontrol.
Contributors
Submitter of the first revision: René Geci
Submitter of this revision: René Geci
Modellers: René Geci

Metadata information


Curation status
Non-curated

Modelling approach(es)
Other

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Model files

new model v9.jl julia script containing the model functions that make up a population genetics/dynamics model 188.05 KB Preview | Download

  • Model originally submitted by : René Geci
  • Submitted: Jan 12, 2023 8:51:06 AM
  • Last Modified: Jan 12, 2023 8:51:06 AM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Jan 12, 2023 8:51:06 AM
    • Submitted by: René Geci
    • With comment: Import of Geci2022