Potassium balance in dairy cows, model update 2021

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Model Identifier
MODEL2201250001
Short description

This updated model is derived from MODEL1710230000 here on Biomodels. In the current version we changed 2 parameter values and the rate equation Keku. Parameter p46, carbohydrate fraction in diet, was changed from 0.08 to 0.3, and parameter p53, basic potassium excretion with urine in the rate KeKu, was changed from 0.01 to 0.25 g/h. The linear dependency of the rate KeKu on Kecf was replaced by a threshold-dependent stimulation. In the corresponding publication we used this model to perform experiments on hypokalemia in cows.

Format
SBML (L2V4)
Related Publication
  • Model-based exploration of hypokalemia in dairy cows.
  • Plöntzke J, Berg M, Ehrig R, Leonhard-Marek S, Müller KE, Röblitz S
  • Scientific reports , 11/ 2022 , Volume 12 , Issue 1 , pages: 12 , DOI: 10.1038/s41598-022-22596-0
  • Zuse Institute Berlin, Takustr. 7, 14195, Berlin, Germany.
  • Hypokalemia in dairy cows, which is characterized by too low serum potassium levels, is a severe mineral disorder that can be life threatening. In this paper, we explore different originating conditions of hypokalemia-reduced potassium intake, increased excretion, acid-base disturbances, and increased insulin-by using a dynamic mathematical model for potassium balance in non-lactating and lactating cows. The simulations confirm observations described in literature. They illustrate, for example, that changes in dietary intake or excretion highly effect intracellular potassium levels, whereas extracellular levels vary only slightly. Simulations also show that the higher the potassium content in the diet, the more potassium is excreted with urine. Application of the mathematical model assists in experimental planning and therefore contributes to the 3R strategy: reduction, refinement and replacement of animal experiments.
Contributors
Submitter of the first revision: Julia Plöntzke
Submitter of this revision: Julia Plöntzke
Modellers: Julia Plöntzke

Metadata information

is
BioModels Database MODEL1710230000
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Non-curated


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Ploentzke2021_potassium_cow.xml Model for potassium metabolism in cows 132.34 KB Preview | Download

  • Model originally submitted by : Julia Plöntzke
  • Submitted: Feb 11, 2022 2:32:03 PM
  • Last Modified: Nov 19, 2022 11:45:41 AM
Revisions
  • Version: 6 public model Download this version
    • Submitted on: Nov 19, 2022 11:45:41 AM
    • Submitted by: Julia Plöntzke
    • With comment: added doi, peer reviewed publication in the journal scientific reports now public available ;-)
  • Version: 5 public model Download this version
    • Submitted on: Feb 11, 2022 2:32:03 PM
    • Submitted by: Julia Plöntzke
    • With comment: Model revised without commit message

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