Starbuck1990 - EGF binding and trafficking dynamics in Fibroblast

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Model Identifier
MODEL2003190005
Short description
mathematical model, with accompanying quantitative experimental data, for binding and trafficking properties of the epidermal growth factor (EGF) receptor on B82 fibroblasts, and propose a theoretical dependence of cell proliferation rate on these properties. Model encoded by Matthieu Maire adn submitted to BioModels by Krishna Kumar Tiwari.
Format
SBML (L2V4)
Related Publication
  • Epidermal growth factor binding and trafficking dynamics in fibroblasts: relationship to cell proliferation
  • Cindy Starbuck, H. Steven Wiley, Douglas A.Lauffenburger
  • Chemical Engineering Science , 1/ 1990 , Volume 45 , Issue 8 , pages: 2367-2373 , DOI: 10.1016/0009-2509(90)80117-W
  • Department of Chemical Engineering University of Pennsylvania Philadelphia, PA 19104 USA Division of Cell Biology and Immunology University of Utah School of Medicine Salt Lake City, UT 84132 USA
  • We provide a mathematical model, with accompanying quantitative experimental data, for binding and trafficking properties of the epidermal growth factor (EGF) receptor on B82 fibroblasts, and propose a theoretical dependence of cell proliferation rate on these properties. The signal for cell proliferation is generated by intrinsic EGF-receptor (EGFR) tyrosine kinase activation via EGF binding at the cell surface, and terminated by receptor/growth factor complex internalization and degradation. Our model consists of kinetic equations which describe the binding, internalization, and recycling of EGF and EGFR, along with a simple expression relation the dependence of cell cycle progression on EGFR dynamics. We show that, with key model parameters determined independently from EGF/fibroblast binding and internalization experiments, our model successfully predicts, as a first step, kinetic data for EGF binding to and internalization by B82 cells at 37°C
Contributors
Submitter of the first revision: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari

Metadata information

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

isDescribedBy (1 statement)

Curation status
Non-curated


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Model files

Starbuck1990.xml SBML L2V4 file for the model 51.13 KB Preview | Download

Additional files

Starbuck1990.cps COPASI 4.27(build217) file for the model 98.19 KB Preview | Download
Starbuck1990.sedml SEDML file for the model 11.03 KB Preview | Download

  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: Mar 19, 2020 5:06:45 PM
  • Last Modified: Mar 19, 2020 5:06:45 PM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Mar 19, 2020 5:06:45 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Import of Starbuck1990 - EGF binding and trafficking dynamics in Fibroblast