Kraan199_Kinetics of Cortisol Metabolism and Excretion.

Model Identifier
BIOMD0000000916
Short description
A new model is proposed to study the kinetics of [3H]cortisol metabolism by using urinary data only. The model consists of 5 pools, in which changes of the fractions of dose are given by a system of 5 ordinary differential equations. After i.v. administration of [3H]cortisol to 8 multiple pituitary deficient (MPD) patients (group I) the urines from each patient were collected in 9-15 portions during the following 3 days. From the urinary data the rate constants of cortisol metabolism were calculated. A published set of urinary data from patients with a normal cortisol metabolism (group II) was used for comparison. The overall half-life of the label in the circulation was 30 min for both groups; the half-life of the label excretion by both groups was 6 h and the time of maximal activity in the main metabolizing pool was 1.8 h in group I and 1.5 h in group II. The 20% of normal cortisol production rate (CPR) in the 8 MPD patients amounted to 7.2 + 1.9/zmol/(m2*d). Therefore, the low CPR but normal rate constants, i.e. a normal metabolic clearance rate of cortisol, in the MPD patients suggest a sensitive adjustment of the cortisol response in the target organs.
Format
SBML
(L2V4)
Related Publication
-
Kinetics of cortisol metabolism and excretion. A hypothetic model based on the cumulative urinary radioactivity in eight multiple pituitary deficient patients.
- Kraan GP, Drayer NM, de Bruin R
- The Journal of steroid biochemistry and molecular biology , 4/ 1992 , Volume 42 , Issue 2 , pages: 169-177 , PubMed ID: 1567783
- Department of Paediatrics, University of Groningen, The Netherlands.
- A new model is proposed to study the kinetics of [3H]cortisol metabolism by using urinary data only. The model consists of 5 pools, in which changes of the fractions of dose are given by a system of 5 ordinary differential equations. After i.v. administration of [3H]cortisol to 8 multiple pituitary deficient (MPD) patients (group I) the urines from each patient were collected in 9-15 portions during the following 3 days. From the urinary data the rate constants of cortisol metabolism were calculated. A published set of urinary data from patients with a normal cortisol metabolism (group II) was used for comparison. The overall half-life of the label in the circulation was 30 min for both groups; the half-life of the label excretion by both groups was 6 h and the time of maximal activity in the main metabolizing pool was 1.8 h in group I and 1.5 h in group II. The 20% of normal cortisol production rate (CPR) in the 8 MPD patients amounted to 7.2 +/- 1.9 mumol/(m2*d). Therefore, the low CPR but normal rate constants, i.e. a normal metabolic clearance rate of cortisol, in the MPD patients suggest a sensitive adjustment of the cortisol response in the target organs.
Contributors
Submitter of the first revision: Ahmad Zyoud
Submitter of this revision: Ahmad Zyoud
Modellers: Ahmad Zyoud
Submitter of this revision: Ahmad Zyoud
Modellers: Ahmad Zyoud
Metadata information
is (2 statements)
isDescribedBy (2 statements)
hasTaxon (1 statement)
hasProperty (3 statements)
occursIn (1 statement)
isDescribedBy (2 statements)
hasTaxon (1 statement)
hasProperty (3 statements)
Mathematical Modelling Ontology
Ordinary differential equation model
NCIt Radioactivity
Gene Ontology cortisol metabolic process
NCIt Radioactivity
Gene Ontology cortisol metabolic process
occursIn (1 statement)
Curation status
Curated
Modelling approach(es)
Tags
Connected external resources
Name | Description | Size | Actions |
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Model files |
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Kraan1992.xml | SBML L2V4 file for the model_ Orignal and Curated | 35.62 KB | Preview | Download |
Additional files |
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Kraan1992.cps | COPASI version 4.27 (Build 217)_Curated | 59.47 KB | Preview | Download |
Kraan1992.sedml | sed-ml L1V2_Curated | 6.15 KB | Preview | Download |
- Model originally submitted by : Ahmad Zyoud
- Submitted: Mar 2, 2020 9:19:36 AM
- Last Modified: Mar 2, 2020 9:19:36 AM
Revisions
Legends
: Variable used inside SBML models
: Variable used inside SBML models
Species
Species | Initial Concentration/Amount |
---|---|
The FOD in the metabolizing tissues X4 BTO:0003092 ; liver ; BTO:0005937 |
0.0 mmol |
The cumulative FOD excreted in the non urinary pool X3 BTO:0003092 |
0.0 mmol |
The FOD in the gallbladder intestinal lumen X5 BTO:0000647 ; gall bladder |
0.0 mmol |
The cumulative FOD excreted in the urine X2 BTO:0003092 |
0.0 mmol |
The FOD in the circulation X1 BTO:0003092 |
1.0 mmol |
Reactions
Reactions | Rate | Parameters |
---|---|---|
The_FOD_in_the_metabolizing_tissues__X4 => The_FOD_in_the_gallbladder___intestinal_lumen__X5 | compartment*(K4*The_FOD_in_the_metabolizing_tissues__X4-K5*The_FOD_in_the_gallbladder___intestinal_lumen__X5) | K5 = 1.2; K4 = 1.2 |
The_FOD_in_the_metabolizing_tissues__X4 => The_cumulative_FOD_excreted_in_the_urine__X2 | compartment*K1*The_FOD_in_the_metabolizing_tissues__X4 | K1 = 3.6 |
The_FOD_in_the_gallbladder___intestinal_lumen__X5 => The_cumulative_FOD_excreted_in_the_non_urinary_pool__X3 | compartment*K2*The_FOD_in_the_gallbladder___intestinal_lumen__X5 | K2 = 1.2 |
The_FOD_in_the_circulation__X1 => The_FOD_in_the_metabolizing_tissues__X4 | compartment*K3*The_FOD_in_the_circulation__X1 | K3 = 26.6 |
Curator's comment:
(added: 28 Feb 2020, 16:39:55, updated: 28 Feb 2020, 16:39:55)
(added: 28 Feb 2020, 16:39:55, updated: 28 Feb 2020, 16:39:55)
The figures have been reproduced successfully without any modifications